Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"AKAP"”.
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Klonierung der cDNA des Protein A Kinase-Adaptor-Proteins-2 und Untersuchungen zur Regulation seiner mRNA in humanen fötalen Osteoblasten
… des Proteinkinase A-Ankerproteins-2 (AKAP-2, 7,5kB) ermittelt. Zu diesem neuen humanen Gen sind bis dato außer einem unvollständigem Datenbankeintrag noch keine experimentellen Daten zur cDNA, mRNA oder zum Protein veröffentlicht. Mittels Northernblot wurde die Regulation der …
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Identification of a Novel ERK 1/2-Interacting A-Kinase Anchoring Protein
… functions as an A-kinase anchoring protein (AKAP), and its ability to bind to the regulatory subunits of PKA, RII and RII, is regulated by ERK1/2 activity and phosphorylation. Interestingly, expression analysis of mRNA suggests RSP3/RSP3H are also present in cells that are thought to contain …
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Redox Regulation of Type Iα PKA in the Heart
… subunits binding A-kinase anchoring proteins (AKAPs), with RIα oxidation enhancing their binding. I assessed whether thioredoxin (Trx) redox recycles disulfide RIα back to its reduced state. In adult rat ventricular myocytes (ARVMs) pre-treatment with diamide (inducing disulfide) potentiated …
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The Non-genomic Signaling Pathways Mediated By G-protein Coupled Estrogen Receptor 1 (GPER) In Coronary Arteries
… by both PKA and Epac; 5) the interaction between AKAP and PKA is involved in the cAMP/PKA signaling mediated by GPER in coronary artery; and 6) GPER potentiates coronary artery contraction via G?? signaling to stimulate transactivation of EGFR and activation of ERK1/2. These findings provided …
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Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
… by interaction with A-kinase anchoring proteins (AKAPs). Additionally, PKA signaling events were reversed when potential PKA type I interactions with AKAPs were disrupted with competitive peptides. Using this approach we found that the redistribution of PKA I to lipid rafts facilitated the …
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The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
… of RII-beta with an A-kinase anchoring protein (AKAP) docking motif in vitro. In addition, we generated novel phosphorylation state specific antibodies to regulatory phosphorylation sites on cAMP-specific phosphodiesterase 4 (PDE4), an important modulator of PKA signaling. These antibodies to …
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Role Of Gravin In Endothelial Wound Healing
<p>Gravin (AKAP12), a 300 kDa AKAP, is widely distributed in cells and binds to several signaling molecules including PKA-RII subunits, PKCα, PDE4, β2 adrenoreceptor and actin cytoskeleton. Initial characterization of gravin has revealed that this protein is undetectable in endothelia in vivo but …
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The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
… Finally, the interaction between Raf-1 and AKAP79 was demonstrated for the first time suggesting the existence of a complex between Raf-1, AKAP and PKA and therefore a possible molecular mechanism for the inhibition of Raf-1 by cAMP through PKA. The data presented in this thesis demonstrates …
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… (MAGUKs) and A Kinase Anchoring Protein 5 (AKAP5) through its C-terminal PDZ-motif. PKA-RII, which directly binds to AKAP5, is responsible for the attenuation of cAMP in response to cAMP- elevating agents.
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Adenylyl Cyclase Type 9: Regulation and Cardiac Function
<p>Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction and relaxation under stress. Sympathetic …