Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"AIM2"”.
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A Non-Canonical Function for NLRP3 and AIM2 in Kidney Diseases
NLRP3 and AIM2 are inflammasome-forming proteins that have been mostly studied in leukocytes. Canonical NLRP3 or AIM2 inflammasomes regulate cytokine maturation and pyroptosis via ASC and caspase-1 activation. Emerging studies demonstrate that NLRP3 or AIM2 is expressed in non-haematopoietic cells …
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The role of NLRP3 and AIM2 inflammasomes in dental pulp inflammation and reparative processes
… but the emerging role of Absent in melanoma 2 (AIM2) and Nod-like receptor protein 3 (NLRP3) inflammasomes is yet to be elucidated. <br/><br/>In this thesis, the role of AIM2 and NLPR3 receptors was explored, both in bacterial and sterile inflammation context. Furthermore, the potential of …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
… tumorigenesis.</p> <p>Absent in melanoma 2 (AIM2) forms an inflammasome with ASC and caspase-1 upon recognition of double-stranded DNA (dsDNA) in the cytosol leading to caspase-1 activation and caspase-1-dependent pyroptosis and release of cytokines IL-1 and IL-18. Mutations in AIM2 are …
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Mechanisms of Microbial DNA Sensing by the AIM2 Inflammasome and Structural Study of Polynucleotydyl Transferase1 (pnt1) from Arabidopsis Thaliana
AIM2 (absence in melanoma 2) can sense foreign cytosolic double-stranded DNA (dsDNA) through the dsDNA binding HIN-200 domain at the C-terminus. Once dsDNA is bound to HIN-200 domain, AIM2 can activate the AIM2 inflammasome, resulting in maturation of pro-interleukin-1? by activation of caspase-1. …
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Inflammasome upregulation and activation in photoreceptors of type 2 diabetes and N-methyl-N-nitrosourea models is attenuated by Wedelolactone
… several types of inflammasome but the so-called AIM2 inflammasome pathway may be the most important in this disease context, since it critically controls the production and maturation of pro-inflammatory cytokines, including IL1B and IL18 via canonical (CASP1) and non-canonical pathways …
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Towards Logical Reasoning and Learning in Open and Dynamic Environments
… the robustness of logical reasoning models. (Aim2) Graph-Augmented Logical Reasoning integrates symbolic logic with graph-based representations to enhance LLM's reasoning accuracy, interpretability, and robustness, addressing hallucinations and ambiguous inference. (Aim3) Applications: This …
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The Skin Remembers: Epigenetic Memories of Inflammation Past
… dsDNA sensor and activator of the inflammasome AIM2, and its downstream effectors caspase-1 and interleukin-1β. Characterization of the chromatin landscape in inflammation-experienced EpSCs reveals specific retention of monomethylation of histone 3 on lysine 4 in memory chromatin domains primed …
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Regulation of osteoblast activity by Pyk2-targeted approaches
… increase cell differentiation and survival. In Aim2, we developed a Pyk2-inhibitor loaded hydrogel and evaluated its viscosity, gelation time, swelling, degradation, and release behavior. We found that a hydrogel composed of PEGDA1000 plus 10% gelatin exhibited viscosity and shear-thinning …