Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"AIEC"”.
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The invasin IbeA and its role in Adherent-Invasive Escherichia coli (AIEC) pathogenesis
… study, an Adherent-Invasive Escherichia coli (AIEC) ∆ibeA mutant was constructed and characterized, and its effect on AIEC adhesion and invasion of intestinal epithelial cells evaluated. The role that this outer membrane protein, IbeA, plays in intra-macrophage survival was also assessed. …
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The role of metabolism in the pathogenesis of adherent invasive Escherichia coli (AIEC)
… coli, called Adherent Invasive Escherichia coli (AIEC) are present in the guts of CD patients at a higher frequency than in healthy subjects, suggesting that they may play a role in the initiation and/or maintenance of the inflammation associated with CD. Two phenotypes define an AIEC and …
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A Larval Zebrafish (Danio Rerio) Model of Adherent-Invasive Escherichia Coli Infections
… US alone. Adherent-invasive <em>E. coli </em>(AIEC) is a pathobiont frequently found in IBD biopsies. AIEC adhere to and invade epithelial cells, and can survive inside macrophages <em>in vitro</em>. However, how AIEC contributes to IBD <em>in vivo</em> remains unclear. Here a larval zebrafish …
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DUAL TARGETING OF RFAP AND FIMH IMPAIRS AIEC INTRACELLULAR SURVIVAL AND LIMITS OMV-DEPENDENT IL-23/PTH17 AXIS ACTIVATION, OFFERING A NOVEL THERAPEUTIC STRATEGY FOR CROHN¿S DISEASE
… the adherent-invasive Escherichia coli strain (AIEC), together with a dysregulated activation of the IL-23/pTh17 axis, is a distinctive feature of CD. In this context, current therapies primarily suppress the exaggerated inflammation without directly targeting AIEC, and the only AIEC-based …
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IDENTIFICATION OF ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC) VIRULENCE DETERMINANTS LEADING TO ACTIVATION OF PATHOGENIC TH17 CELLS IN CROHN¿S DISEASE.
… enrichment of adherent-invasive E. coli (AIEC) pathotype. Notably, in a recent yet unpublished work, we described a new subset of pathogenic Th17 cells (pTh17), selectively enriched in the gut of CD patients that are specifically activated by AIEC strain. However, the molecular mechanism …
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Evaluation of Intestinal Microbial Diversity and a New Antibiotic Regimen in Crohn's Disease Patients
… such as adherent-invasive Escherichia coli (AIEC) have also been proposed in CD association. To date, only one study investigated both MAP and AIEC simultaneously using peripheral blood but not in affected intestinal tissues. A standardized and effective antibiotic therapy against MAP and/or …
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Phenotypic characterisation of wild type and mutant strains of adherent invasive Escherichia coli and Shigella, in vitro, ex vivo and in vivo models
… individuals.;Adherent-invasive Escherichia coli (AIEC) has been implicated in CD, as has Shigella sonnei due to the shared inflammatory characteristics and susceptible genetic background of Shigellosis and Crohn's disease patients, with both microorganisms showing resistance to …
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Identification of bacteria-regulated mechanisms for the pathogenesis of inflammatory bowel diseases (IBD) and development of upconverting nanoparticle (UCNP) luminescence imaging for the monitoring of gut bacteria
… development. Adherent-invasive Escherichia coli (AIEC) is widely prevalent and heterogeneously present in the mucosa of IBD patients, particularly in Crohn’s disease. We hypothesise that the presence of AIEC in the gut of IBD patients might explain the NSAID-induced inflammation in IBD under low …
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
… Shigella and adhesive invasive Escherichia coli (AIEC) cause infections characteristic of hyperinflammation. These infections require antimicrobial therapy. However, due to the widespread emergence of multiple drug-resistant strains, alternative strategies must be sought to combating infectious …
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The effects of low-shear modeled microgravity on Streptococcus pneumoniae and adherent-invasive Escherichia coli
… and on adherent-invasive Escherichia coli (AIEC) physiology and colonization properties. Habitation in space exposes both humans and microbes to microgravity conditions which are characterized by reductions in fluid shear forces. Areas of low-shear stress are also encountered in …
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The role of genetic alterations in the gut-joint axis of Crohn's disease and Spondyloarthropathies
… early cytokine secretion after infection with AIEC, a bacterial strain specifically associated with CD. Moreover, these polymorphisms also seem to induce a disturbed humoral response, reflected by the association with anti-Saccharomyces cerevisiae antibodies. We also confirmed the link between …
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Influence of intestinal inflammation on bacterial protein expression in monoassociated mice
… either with the adherent-invasive E. coli (AIEC) strain UNC or the probiotic E. coli Nissle, two different mouse models of intestinal inflammation were analysed: On the one hand, severe inflammation was induced by treating mice with 3.5% dextran sodium sulphate (DSS). On the other hand, a …