Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"AID2"”.
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Mapping the cell cycle-dependent centrosomal interactome
… enrichment results, fluorescently tagged AATF-AID2-mNeonGreen was found to be predominantly localised on the nucleolus. Similarly, PPP1CB-AID2-mNeonGreen could not be detected on the centrosome, and its degradation showed no effects on cell cycle progression. For TRIM25-AID2-mNeonGreen, it was …
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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC
… degraded in a xenograft model of ccRCC using AID2 technology, and that combining this with RNA-seq uncouples direct targets from downstream signalling cascades. This unbiased method enabled the shortlisting of clinically relevant candidate HIF2A direct target genes which could then be …
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Analysis of the functions of phosphoprotein phosphatase 1 catalytic subunits during cell division
… of the target protein. I next tested the AiD2 system to study PP1 phosphatases and ultimately generated human colon tumour 116 (HCT116) cell lines containing endogenously tagged PP1β and PP1γ and supervised the generation of a PP1α cell line. I found that degradation of PP1β in a late …