Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 133 for “"AHR"”.
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Investigation of ARNT isoform-specific regulation of AHR signaling
… opposing roles in aryl hydrocarbon receptor (AHR) signaling, as ARNT isoform 1 suppresses AHR activity, whereas ARNT isoform 3 is needed for AHR target-gene transcription. Furthermore, to explore this suppressive role, we investigated a unique modification specific only to ARNT isoform 1 – …
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Microbial Metabolite Regulation of Microglial AHR Signaling in Alzheimer’s Disease
… understood. The aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor responsive to tryptophan metabolites, has recently gained attention as a key regulator of neuroinflammation and microglial function. I hypothesize that the loss of beneficial microbial AHR ligands, …
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Bacterial expression of radio-labeled recombinant proteins for studying AHR signalling
… transcription factor Aryl Hydrocarbon Receptor (AHR) forms a DNA binding heterodimer with the Aryl Hydrocarbon Nuclear Translocator (ARNT) in response to planar aromatic hydrocarbons. In addition to AHR and ARNT there are at least three other proteins involved in AHR signaling. These proteins are …
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Cracked Cans, Bent Wire: Dating Historical Metal at Biry/Ahr House, Castroville, Texas
… metal consumption practices over time at Biry/Ahr House, a frontier settlement in Castroville, Texas. Alsatian immigrants settled this site in Medina County as part of the empresario system of the 1840s. Biry/Ahr House was home to two families, the Birys (1844-1921) and the Groff/Tschirharts …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE
… disturbances. Aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, mediates systemic metabolism and toxicity of a range of environmental contaminants. Epidemiological studies have established a positive correlation between exposure to dioxins and other synthetic organic …
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Identification de co-régulateurs impliqués dans la réponse transcriptionnelle induite par les récepteurs AhR et ER[alpha]
AhR est un facteur de transcription ayant un rôle dans la physiologie normale comme le développement du foie et du système immunitaire. Ce facteur est aussi responsable du métabolisme des"Aryls hydrocarbones" et est impliqué dans la détoxification cellulaire. Il a été montré, notamment dans le …
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Novel Functions of the Transcription Factor Aryl Hydrocarbon Receptor (AHR) and Its Tryptophan-Derived Ligands in Cancer Cells
… MYC and the aryl hydrocarbon receptor (AHR). The role of MYC in regulating tryptophan (Trp) metabolism was investigated in colon and liver cancer cells using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Our findings reveal that MYC enhances the …
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Natürliche Lebensmittelinhaltsstoffe als Liganden des Ah Rezeptors - Identifizierung und Charakterisierung von Beta-Carbolinen mit AhR Ligandenpotential mittels funktioneller Bioassays
… unserer Untersuchungen anhand von funktionellen AhR-abhängigen Bioassays stand die Klasse der ß-Carboline und ihrer Derivate, deren natürliches Vorkommen bereits in zahlreichen Lebensmitteln und im menschlichen Organismus beschrieben ist. Die ß-Carboline wurden für die Untersuchung auf ihr …
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Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells
The Aryl Hydrocarbon Receptor (AhR) and the Aryl Hydrocarbon Nuclear Translocator (ARNT) play a role in mediating transcriptional responses to environmental pollutants, including the highly toxic compound 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD) but also endogenous physiological ligands. More …
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Overexpression of Human Aryl Hydrocarbon Receptor in <i> E.coli</i> Using Two Different Solubility Enhancing Tags
… are mediated via aryl hydrocarbon receptor (AhR) signaling pathway. AhR is a ligand sensitive transcription factor. The unbound AhR resides in cytoplasm as a complex containing p23, Hsp90 and XAP2. Upon ligand binding, AhR undergoes conformational change and translocates into the nucleus. …
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Glucose and Lipid Dysregulation Following Loss of Hepatic Aryl Hydrocarbon Receptor in Mice.
The aryl hydrocarbon receptor (AhR) is a cytosolic, ligand activated transcription factor commonly known for its role in environmental toxicant metabolism. However, the generation of AhR knockout (AhR-KO) mice has shown physiological roles for the AhR in normal liver growth and development, insulin …
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Novel Roles of the Aryl Hydrocarbon Receptor in Normal Physiology and Epigenetic Reprogramming
The Aryl hydrocarbon Receptor (AhR) is a ubiquitously expressed, evolutionarily conserved, ligand activated, cytosolic transcription factor belonging to the basic Helix-loop-helix Per-ARNT-Sim superfamily of proteins. AhR has classically been associated with environmental toxicology owing to the …
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REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY ARYL HYDROCARBON RECEPTOR
The aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, plays a crucial role in regulation of xenobiotic metabolism. AhR is also involved in dioxin-induced metabolic disorders and alteration of circadian rhythm. Furthermore, circadian clock disruption and metabolic dysfunction …
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Novel Insights Into Normal Aryl Hydrocarbon Receptor Biology Through the Regulation of Stanniocalcin 2
… and evidence that the Aryl hydrocarbon Receptor (AhR) can promote cell survival following intrinsic apoptotic stimuli is integral to the regenerative process. Recent evidence suggests that the AhR promotes cell survival through the PI3K-Akt/PKB axis in the absence of an exogenous ligand. However …
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Environmental signals that control T lymphocytes in the gastrointestinal tract
… (ARNT) binds the Aryl Hydrocarbon Receptor (AHR) and also the Hypoxia Inducible Factor-1α (HIF-1α). Both the AHR and HIF-1α are key sensors of the microenvironment. Dietary tryptophan metabolites and microbiota catabolites are AHR ligands and HIF-1α is a sensor of low oxygen tension. Deletion …
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Analysis of the interaction between the co-chaperone p23 and the aryl hydrocarbon receptor
<p>The aryl hydrocarbon receptor (AhR) carboxyl terminal transcriptional activation domain was cloned, purified in denatured conditions from bacteria, refolded via limited dialysis, and analyzed for proper refolding via co-immunoprecipitation with the known binding partner SRC-1. This AhR NΔ515 …
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Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells
<p>The aryl hydrocarbon receptor (AhR) is a ligand-activated bHLH-PAS protein that binds its partner, the aryl hydrocarbon receptor nuclear translocator (Arnt), in the nucleus to initiate the expression of proteins involved with detoxification. Published work suggests cross-talk between both …
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The Role of the Aryl Hydrocarbon Receptor in Tumor Growth and Chemoresistance
The aryl hydrocarbon receptor (AHR) has been shown to play a role in cancer initiation and progression in oral squamous cell carcinomas (OSCC), and other cancers. The AHR is activated by environmental toxins, including polycyclic aromatic hydrocarbons, which are commonly found in cigarette smoke. …
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Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor which regulates toxic response to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand activation, the AhR translocates to the nucleus, dissociates from its chaperone complex, and …
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