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Showing 1 to 12 of 12 for “"AG490"”.
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Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
… In present study, we investigated whether AG490, a specific Janus kinases 2 (JAK2) inhibitor had an effect on oxidative stress-induced cytotoxicity in cultured primary cortical neurons. AG490 significantly protected neuronal cell death against various oxidative stimuli, such as hydrogen …
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Role of interleukin-6 signaling via the Jak/Stat pathway in human myeloma and effects on mediators of cell survival and proliferation
… in U266 cells by the Jak kinase inhibitor, AG490, or dominant negative Stat3 expression construct (Stat3/3) results in downregulation of Bcl-XL expression, and enhanced sensitivity to Fas-mediated apoptosis. Treatment of myeloma patient specimens with AG490 was sufficient to inhibit Stat3 …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… suppressing tumor cell growth. Tyrphostin AG490, the first described Jak2 inhibitor, displays poor pharmacology and requires high concentrations for anti-tumor activities. Our research group screened a small library of AG490 structural analogues and identified WP1130 as a potent inhibitor …
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The role of adiponectin and the adipocyte in energy metabolism and inflammation
… with or without pretreatment of 10 &mgr;M AG490, in hyper-glycemic or normo-glycemic conditions for 6 h. There was no effect of cytokines at 5.5 mM glucose for R1 expression. However, there was a trend for a down-regulation of R2 by AG490-TNF&agr; (P < 0.07). At 25 mM glucose, there was an …
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Role of JAK2 in the Proliferation of Activated Astrocytes
… In the present study, systemic administration of AG490, a JAK2 inhibitor remarkably reduced the reactive astrogliosis in cortical swab injury. To investigate the role of JAK2 on proliferation of astroglial cells, JAK2 phosphorylation and the effects of JAK2 inhibitors on thrombin-induced astrocyte …
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STAT5 regulierte differentielle Genexpression in prä-B-leukämischen Zellen
… und Inhibition der STAT5 Phosphorylierung durch AG490, einen spezifischen JAK-Kinaseinhibitor. <br>Diese Charakteristika legen nahe, daß BaMRS Zellen funktionell und phänotypisch Zellen der ALL nahe kommen. Daher wurden BaMR und BaMRS Zellen im Vergleich mit der Methode des Differential Display …
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Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
… showed activation of STAT3 in response to IGF-i. AG490, an inhibitor of STAT3, inhibited IGF-i induced proliferation of hCASMCs as detected by BrdU cell proliferation assay. Over-expression of SOCS3 in hCASMCs also resulted in suppression of IGF-i induced STAT3 activation and nuclear localization …
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Loss of Gprc5A Enhances Survival In Normal and Malignant Lung Epithelial Cells By Eliciting Persistent Stat3 Activation Induced By Autocrine Lif
… cells isolated from normal and tumor tissue with AG490, a Stat3 signaling inhibitor, or with dominant negative Stat3(Y705F) increased starvation-induced apoptosis and inhibited anchorage-independent growth. </p> <p>These results suggest that persistent Stat3 activation increased the survival and …
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The Role of STAT and the Jak/STAT Pathway In Mediating the Effects of Interleukin-6 on StAR Expression
… of IL-6 alone or, congruently with either a Jak (AG490) or STAT3 (Piceatannol) inhibitor, to show the effects of STATs and the Jak/STAT pathway on StAR. Luciferase assays were performed in order to observe the effects on induction of the StAR promoter. RT-PCR and western blots were also performed …
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Gangliosides와 oxidized low density lipoprotein (oxLDL) 에 의한 신경교세포의 활성조절 및 그 기전에 대한 연구
… Inflammatory Gene Expression 28 5. AG490 Reduces Gangliosides-induced Release of NO 28 6. ERK Activity Appears to be Regulated by JAK Activation 30 7. Sialic Acid Residues Are Important for Gangliosides-induced Phosphorylation of STAT 32 B. Oxidized Low Density Lipoprotein (oxLDL) …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… of JAK/PI3K/PDE3B respectively Tyrphostin AG490, LY-294002, and 3-isobutyl-lmethylxanthine reversed the inhibitory effect of G-CSF on corticosterone synthesis. We report that G-CSF was neuroprotective in neonatal HI by reducing infarct volume, by suppressing the HI-induced increase of the …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… of JAK/PI3K/PDE3B respectively Tyrphostin AG490, LY-294002, and 3-isobutyl-1methylxanthine reversed the inhibitory effect of G-CSF on corticosterone synthesis. We report that G-CSF was neuroprotective in neonatal HI by reducing infarct volume, by suppressing the HIinduced increase of the …