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Showing 1 to 17 of 17 for “"AFB1"”.
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DNA Repair Mechanisms, Aflatoxin B1-Induced DNA Damage and Carcinogenesis
… between DNA repair mechanisms, aflatoxin B1 (AFB1)-induced DNA damage and carcinogenesis. Mice deficient in 8-oxoguanine glycosylase (OGG1, the rate-limiting enzyme in repair of oxidized guanine), mice heterozygous for OGG1, and wild type mice, were exposed to a single tumourigenic dose (50 …
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Transcriptional response and DNA adduct analysis of murine liver exposed to aflatoxin B₁ by Jeanette Louise Allen Fiala.
Human dietary exposure to aflatoxin B1 (AFB1) is linked to hepatocellular carcinoma (HCC), especially in areas where significant hepatitis B infection is concurrent. Susceptibility to this carcinogen varies among species. Neonatal mice, like rats and most other species, are highly sensitive to the …
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BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE
… of HepG2 cells exposed to aflatoxin B1 (AFB1). Cis-terpenones combined with AFB1 in HepG2 cells increased cell viability suggesting chemopreventive effects against AFB1. Further study revealed a mechanism for this effect: HCT and oxidized HCT (OHCT) inhibited activity of P450 1A/B, which …
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Evaluation of aflatoxin-related products from ozonated corn
… layer chromatography. HPLC analysis of ozonated AFB1 revealed the presence of six major peaks. MALDI-MS analysis detected compounds that have higher molecular weights than AFB1. The dichloromethane fraction contained compounds with molecular ion peaks at 459 and 439 m/z while the water fraction …
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Effects of aflatoxin B₁ (AFB₁) on hepatic gene expression in pigs and turkeys
… ameliorate the adverse effects of aflatoxin B1 (AFB1) on performance of pigs and, to identify changes in gene expression in liver of pigs fed aflatoxin (AF). Twenty crossbred weanling pigs were weighed, ear-tagged, and assigned to each of four dietary treatments, which included: 1) basal diet …
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Human aflatoxin exposure in south-western Ethiopia assessed using serum biomarkers: A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Science at Lincoln University
… collected were analysed for aflatoxin B1 (AFB1), aflatoxin B1-lysine (AFB1-lys), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1), aflatoxin G2 (AFG2) and aflatoxin M1 (AFM1) using liquid chromatography-tandem mass spectrometry. All six of the analysed aflatoxins were detected in 64/100 (64%) of …
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Impact of dietary modification on aflatoxicosis in poultry
… dietary nutrients. Exposure to 2 mg/kg cultured AFB1 led to reduced feed intake, BW gain, depressed feed efficiency, increased relative liver weight, negatively affected serum measures and complement activity, as well as affected hepatic gene expression in 21 d broiler chicks. Additionally, …
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Toxicity of mycotoxins to insects and underlying molecular and biochemical mechanisms
… the developmental delay caused by aflatoxin B1 (AFB1), and found that the LC50 (defined as the concentration preventing 50% of newly hatched larvae from entering the second instar within 48 hr) for AFB1 is 100 times greater for A. transitella than that for H. zea. Similarly, A. transitella first …
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Study of degradation of aflatoxins after sonication and their determination by HPLC-QqQ-MS
… των βασικών παραμέτρων στην Αφλατοξίνη Β1 (AFB1), έγινε κινητική μελέτη της αποδόμησής της και επιλέχθηκαν οι κατάλληλες συνθήκες για εφαρμογή σε πρότυπο μείγμα που περιλαμβάνει και τις υπόλοιπες αφλατοξίνες (B2, G1 και G2) καθώς και σε ρόφημα φυτικής προέλευσης τεχνικά επιμολυσμένο με AFB1. …
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Investigation of methods for reducing aflatoxin contamination in distillers grains
… During wet heating for 1 h at 80°C, 73% of the AFB1 was degraded. Degradation of AFB1 by wet heating involves hydrolysis of the furofuran moiety and the lactone ring along with further decarboxylation. Microwave heating produced the same degradation products as conventional heating, indicating …
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The toxicity and mutagenicity of the aflatoxin B₁ formamidopyrimidine DNA adduct
Aflatoxin B1 (AFB1) is a fungal metabolite that contaminates the food supply in certain areas of the world. It is produced by Aspergillusflavus and related fungi that grow on improperly stored foods such as corn, rice, and peanuts. Epidemiological studies have shown a correlation between exposure …
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Design Synthesis and Evaluation Of Diterpenones As Potent Chemopreventive Agents For Aflatoxin B1 Induced Carcinogenesis In Human Liver Cells
… AS POTENT CHEMOPREVENTIVE AGENTS FOR AFB1 INDUCED CARCINOGENISIS IN HUMAN LIVER CELLS By Miguel A. Zuniga, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Major Director: Qibing Zhou, …
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Effects of clay supplementation on rumen environment, metabolism, inflammation, and performance in dairy cows
… challenge consisted of 100 μg of Aflatoxin B1 (AFB1)/kg of dietary DMI. The material was fitted into 10-mL gelatin capsules (TORPAC, Fairfield, NJ) and administered into the rumen through the rumen-cannula based on the average DMI obtained on d 12 to 14. Treatments for both challenges were: POS, …
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Characterization of the Arabidopsis thaliana Auxin F-Box Family Members AFB4 and AFB5
… identified a family of auxin receptors, TIR1, AFB1, AFB2 and AFB3, are key components of this process. This work is focused on the characterization of two additional members of this family AFB4 and AFB5. Using a combination of molecular biology, genetics and biochemistry I have begun the …
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Food safety through fungal disease and mycotoxin mitigation on dairy farms: From field to feed and the rumen
… to 24 cows received an AF challenge (100 μg of AFB1/kg of diet DM administered orally). Treatments were: no AD and no AF challenge (CON); no AD plus an AF challenge (POS); 30 g per cow per d of an AD with proprietary composition of yeast cell wall and bentonite clay (P30); 60 g per cow per d of …
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Molecular Sensors at the Nanoscale: Modeling and Technology
L'abstract è presente nell'allegato / the abstract is in the attachment
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Prozess- und Diagnosequalität in Präklinik und Notaufnahme des Universitätsklinikums Göttingen
HINTERGRUND: Angesichts der rasanten Entwicklung und aktuellen Diskussionen über Veränderungen in der Struktur der Notfallmedizin in Deutschland wird die Notwendigkeit für eine Bestandsaufnahme des Ist-Zustandes deutlich. Nur so ist es möglich, eine Veränderung der Qualität nach einem strukturellen …