Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"AF4"”.
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A Study of the Therapeutic Potential of AF4 Mimetic Peptides
… the SEC as a means of inhibiting MLL leukemia. AF4 and AF9 proteins co-purify with components of the SEC and directly interact with each other. Our laboratory has previously identified the domain of AF4 which is required for AF9 interaction and demonstrated that inhibition of this interaction …
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Significance of Protein Interactions in Mediating AF9 Function
… AF9.</p><p>Furthermore, it has been shown that AF4 and AF9 exist in a large multiprotein complex containing positive transcription elongation factor b (P-TEFb) and therefore are linked to transcriptional elongation. To understand the significance of the AF9-AF4 interaction, our laboratory has …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… interacts with gene regulatory proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are retained in the oncogenic MLL-AF9 fusion protein, and may be required for leukemic transformation.</p><p>Using bone marrow progenitor cells isolated from conditional Af9 knockout mice, we …
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A Comprehensive View of Electrosleep: The History, Finite Element Models and Future Directions
… High-Definition (HD) electrodes on AF3 and AF4 (active), 5x7 cm sponge on neck (return); HD electrodes on AF3 and AF4 (active), 5x7 sponge electrode on Iz (return). A high concentration of electric field was found on the optic nerve, with levels lowered as the electrodes moved further away …
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Topology of Genes in Mammalian Cell Nuclei with Special Emphasis on the MLL Gene and Its Translocation Partners
… of MLL, five of its translocation partners, (AF4, AF6, AF9, ENL and ELL) and four control loci (2q33, 2q35, 7q22 and 8q34) were analyzed in different human cell lines of hematopoietic origin and in primary hematopoietic stem cells. Despite the cell materials’ differences in maturation state, …
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The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
… associated adaptor proteins such as BRD4 and AF4 to gene promoters, which are critical for the maintenance of the MLL-AF9 transcriptional programme. Although not found to be mutated among cases of AML, KAT7 is a plausible therapeutic target for this poor prognosis subtype of AML.
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Chracterisation of Chromosomal Aberrations in Acute Lymphoblastic Leukaemia Patients Attending the University Teaching Hospital in Lusaka
… Other translocations screened, t(11;23)/MLL-AF4 and t(12;21)/ETV6/RUNX1)were not detected. There will be need to carry out this study on a larger scale nationwide in order to determine the type and frequency of chromosomal aberrations among acute lymphoblastic leukaemia patients in Zambia. …
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Total N-nitrosamine Precursor Adsorption with Carbon Nanotubes: Elucidating Controlling Physiochemical Properties and Developing a Size-Resolved Precursor Surrogate
… with asymmetric flow field-flow fractionation (AF4) with inline fluorescence detection (FLD) and whole water fluorescence excitation-emission matrices (EEMs). TONO precursor surrogates were discovered, capable of predicting changes in TONOFP in WWTP samples that have undergone oxidation (R2 = …
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Mechanistic Insights into Direct Interactions that Mediate the Activity of DOT1L Complex in MLL-Rearranged Leukemia
… of SEC (Super Elongation Complex) such as AF4 (or AFF4), AF9 (or AF9-related ENL), and ELL1. However, any effect of DOT1L on other transcriptional steps is not known. Addressing these gaps, the present study employs a robust biochemical approach to underscore the importance of both MLL N …
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From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
… more than 80 fusion partners, MLL-AF9, MLL-AF4 and MLL-ENL make up more than 60% of cases involving *MLL1* translocations. Conventional retroviral transduction models commonly use lineage depleted or c-Kit enriched mouse bone marrow haematopoietic stem and progenitor cells (HSPCs) that …