Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"AECs"”.
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Do respiratory epithelial cells ‘remember’ early life microbial exposure through epigenetic changes?
… epigenetically imprint airway epithelial cells (AECs), thus changing how these cells respond to subsequent challenges, which in turn provides a potential link between RSV infection and asthma development. First, I established in vitro and in vivo AEC experimental systems that would allow us to …
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Investigation of the proteins SPARC and HMGB1 in chronic airways disease
… cells including airway epithelial cells (AECs) and airway smooth muscle (ASM) cells, and also determined if its expression is altered in cells derived from subjects with asthma or COPD. We demonstrated that TGF-β increases SPARC expression and release in AECs and ASM cells, although to a …
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Do You Hear Us? Amplifying Alternative Pathways for High School Pushouts Through Youth Participatory Action Research
… been to develop Alternative Education Campuses (AECs). However, there is a current gap in the research that amplifies the counter narratives of students currently enrolled at an AEC, through their own words, using Youth Participatory Action Research (YPAR). Studies conducted with students who …
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INVESTING THE ROLES OF E26 TRANSFORMATION-SPECIFIC HOMOLOGOUS FACTOR IN CYSTIC FIBROSIS LUNG DISEASE
… cells (hiPSC)-derived Airways Epithelial Cells (AECs). We first explored two differentiation protocols that generate lung AECs as organoids and Air-Liquid-Interface (ALI) cultures and outlined their respective advantages and limitations. Then, using the most robust differentiation protocol, we …
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
… on ENaC activity in CF airway epithelial cells (AECs). Further, two highly selective and potent furin inhibitors, BOS-981 and BOS-318 were characterised, with the aim of determining whether selective inhibition of furin has the potential to reduce ENaC-mediated sodium transport and improve …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… BMP signalling in adult airway epithelial cells (AECs) and to further investigate BMP signalling during airway inflammation. AECs used included the transformed bronchial cell line, BEAS-2B, the adenocarcinoma-derived cell line, A549, and normal primary murine airway epithelial cells (MAECs). BMP2 …
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RAC1-Mediated Actin Cytoskeleton Remodeling and Monolayer Barrier Properties of Stretched Alveolar Epithelial Cells
… deformation and reduced barrier function. AECs maintain integrity of the blood-gas barrier with gasket like intercellular tight junctions (TJ) which are anchored internally to the actin cytoskeleton. Our goal was to evaluate the effect of physiologically relevant, high magnitude biaxial …
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Roles of Neutrophil Activation in Asthma
… expression levels in airway epithelial cells (AECs) were evaluated by CCK8 assay and Western blot analysis. Peripheral blood eosinophils (PBEs) were isolated from peripheral blood of human donors using MACS system. Secretion levels of IL-8, eosinophil cationic protein (ECP) and eosinophil …
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Contemporary Perspectives on the Development of Australia’s Animal Research Regulation
… appraise the processes Animal Ethics Committees (AECs) undertake in reviewing and approving applications for animal research. I respond to a claim that these committees do not reject projects by conducting a quantitative analysis of application outcomes in a sample of Australian AECs. I conclude, …
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Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition
… remains unclear. We report that injury to AECs forces proliferation and cellular transitions including epithelial-to-mesenchymal transition (EMT) during migration and the reverse (MET) during wound resealing. Multiple assays established that oxidative stress (OS) at term induces EMT, …
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Enteral docosahexaenoic acid supplementation to attenuate inflammation in the preterm infant
… enteral DHA and soy emulsions in human type II AECs, one of the primary cell types affected in respiratory disorders, was assessed in vitro. The enteral emulsions assessed in the N3RO RCT were tested in conjunction with other commercially available parenteral lipid emulsions. Omega-3 DHA in both …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… newborn ‘‘naive’’ airway epithelial cells (AECs) indefinitely for use in subsequent experimentation, e.g., once clinical phenotypes, like severe RSV or asthma, have been established. We next sought to establish if differential RSV‐induced innate immune responses of airway epithelial cells …