Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"ADRA2A"”.
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Mechanisms of defective insulin secretion in type 2 diabetes
… variants for type 2 diabetes near TCF7L2 and ADRA2A were associated with reduced glucose-induced insulin secretion. Moreover, susceptibility variants near ADRA2A, KCNJ11, KCNQ1, and TCF7L2 were associated with reduced depolarization-evoked insulin exocytosis. We combined our results to create …
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Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
… consisting of 4 SNPs in or near TCF7L2, KCNJ11, ADRA2A and KCNQ1 that successfully predict reduced exocytosis, calcium-sensitivity, granular docking and GSIS. Finally, in paper V, knock-down of rno-microRNA-335 in insulin-secreting cells was found to increase Stxbp1 expression which correlates …