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Showing 1 to 2 of 2 for “"ADP-ribosyltransferase activity"”.

  1. Important role of the type VI secretion system in the virulence of an emergent human pathogen Aeromonas hydrophila: Delineating the mechanism of action of its effectors

    … (Hcp). We provided evidence that VgrG1 showed ADP-ribosyltransferase activity associated with its VIP-2 domain. Our data indicated that episomal expression of the vgrG1 gene in HeLa Tet-Off cells disrupted the actin cytoskeleton, followed by a decrease in cell viability and an increase in …

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  2. Mechanism of action of AexU, a new type III secretion system effector from an emerging human pathogen Aeromonas hydrophila

    … as AexU) of the T3SS, which exhibited ADP-ribosyltransferase (ADPRT) and GTPase-activating protein (GAP) activity. AexU was successfully expressed in the HeLa cell Tet-Off system and I provided evidence that cells expressing and producing the full length AexU showed actin reorganization …

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