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Showing 1 to 20 of 98 for “"ADP-ribose"”.

  1. Enzymatic synthesis of defined-length poly(ADP-ribose) and the investigation of cell-permeable poly(ADP-ribose) glycohydrolase inhibitors

    Yang, WoojinUniversity of Illinois at Urbana-Champaign2016

    Poly(ADP-ribosylation) (PARylation) is an important post-translational modification that maintains genomic stability in a cell. Engaging in important cellular processes such as DNA repair and cell death signaling, PARylation has gathered considerable interest as a target for genotoxic chemotherapy …

    uiuc Repository record

  2. The chemical and enzymatic synthesis of poly(ADP-ribose)

    Lambrecht, MichaelUniversity of Illinois at Urbana-Champaign2016

    Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity associated with the synthesis of poly(ADP-ribose). Discussed here are …

    uiuc Repository record

  3. Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization

    Pater, JustinUniversity of Saskatchewan2013

    … cytoplasmic adapter protein. Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be necessary for proper trophoblast syncytialization. Thus, it was hypothesized that …

    sask Repository record

  4. DEVELOPING SMALL-MOLECULE PROBES AND INHIBITORS FOR ADP-RIBOSE-BINDING PROTEINS

    Peng, KewenCornell University2025

    … protein adenosine diphosphate ribosylation (ADP-ribosylation) serves as key effectors and regulators in a plethora of biological processes. Although the biological roles of mono-ADP-ribosylation (MARylation) and poly-ADP-ribosylation (PARylation) have been extensively studied, and many …

    cornell Repository record

  5. Structure and function of the human Poly(ADP-ribose) polymerase enzyme family

    Rood, Jennifer E. (Jennifer Evelyn)Massachusetts Institute of Technology2013

    The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While PARP-1 and some other PARPs have been extensively functionally characterized, …

    mit Repository record

  6. A reverse genetics study of the Human Coronavirus 229E ADP-ribose-1"-phosphatase

    Dammann, SabineQueen's University Belfast2011

    … a conserved nsp3 domain called ADRP (ADP-ribose -1”-phosphatase) was investigated using a reverse genetics approach. To better understand the role of the ADRP in viral replication, a set of HCoV-229E ADRP mutants was generated, including viruses with a (i) mutation in the putative ADRP …

    qu-belfast Repository record

  7. Development of poly(ADP-ribose) glycohydrolase inhibitors and tetracyclic indoles as anticancer compounds

    Knezevic, ClaireUniversity of Illinois at Urbana-Champaign2014

    … herein is the target-based development of poly(ADP-ribose) glycohydrolase (PARG) inhibitors as putative anticancer compounds as well as the discovery of a class of potent anticancer tetracyclic indoles through a phenotypic screen. PARG plays a crucial role in DNA damage repair, and lack of PARG …

    uiuc Repository record

  8. The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death

    Finch, Kristin E.University of Illinois at Urbana-Champaign2011

    … repair of single strand DNA breaks by the poly(ADP-ribose) (PAR) cycle, which is an enzymatic cycle that promotes DNA repair after mild DNA damage. In contrast, upon severe DNA damage, the PAR cycle is known to promote acute cell death, which can result in ischemia or neurological diseases. …

    uiuc Repository record

  9. Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family

    Vyas, Sejal (Sejal Kamlesh)Massachusetts Institute of Technology2014

    The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, …

    mit Repository record

  10. Poly (Adp) Ribose Polymerase Inhibitors For The Treatment of Malignant Peripheral Nerve Sheath Tumor

    Kivlin, Christine M2016

    … to improve the outcome for MPNST patients. Poly (ADP) ribose polymerase (PARP) inhibitors were first reported over a decade ago to have substantial anti-tumorigenic effects in malignancies with defective DNA repair, specifically those with <em>BRCA1/2</em> (breast cancer, early onset 1/2)<em> …

    uthsc Repository record

  11. Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response

    김, 재진2016

    … 1 functions in the DNA damage response 9 D. Poly(ADP-ribosyl)ation mediated DNA damage response signaling 10 1. DNA damage induced PARP1 activation 10 2. Free pADPr polymer function in DNA damage response 11 E. Aim of this study 12 Ⅱ. MATERIAL AND METHODS 13 1. Cell lines 13 2. Plasmids and …

    ajou Repository record

  12. A Solid State NMR Investigation of Poly (ADP-ribose) and Its Involvement in Tissue Calcification

    Murgoci, AdrianUniversity of Cambridge2022

    … components. The Duer group discovered that poly (ADP-ribose) (PAR), a biological polymer produced in response to DNA damage, is deposited in the calcified matrix of bone and pathologically mineralised arteries and could play an important role in mineralisation. PAR has affinity for calcium, …

    cambridge Repository record

  13. Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii

    Gais, Andrea Nadja2012

    … auch die Inhibierung der Expression der Poly(ADP-Ribose) Polymerase (PARP)-1. PARP-1 ist ein nukleäres Protein und spielt eine wichtige Rolle in verschiedenen zellulären Abläufen einschließlich DNA Reparatur, Apoptose, Nekrose und Regulation der Genexpression. Außerdem ist es an der …

    goettingen Repository record

  14. Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target

    Botta, DavideThe University of Arizona.2010

    Poly(ADP-ribosyl)ation is a reversible post-translational modification of histones and nuclear proteins rapidly stimulated by DNA damage. Its homeostasis is a dynamic process regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) …

    arizona-thes Repository record

  15. The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.

    Mohamad, Kamaran KarimUniversity of Essex2016

    … DNA-repair and protein modifying enzyme poly (ADP-ribose) polymerase-1 (PARP-1). Consequently, the effect of PJ-34, a potent inhibitor of PARP on PARP-1 activation induced by LPS was studied on THP-1 cells. In response to LPS, PJ-34 reduced the PAR formation and down regulates the expression of …

    essex Repository record

  16. Differentiation-associated Downregulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1) Expression in Skeletal Muscle Increases Its Resistance to Oxidative Stress

    Oláh, Gábor2016

    hungary-te Repository record

  17. Development of methods to investigate poly(ADP-ribose) polymerase-1 activity and DNA base-excision repair in relation to cancer and ageing

    Pfeiffer, RagenUniversität Heidelberg

    … of a new immuno-dot-blot method to detect poly(ADP-ribosyl)ation capacity in cells and the automation of the fluorescence detected alkaline DNA unwinding (FADU) assay to measure DNA strand breaks and repair. Poly(ADP-ribose) polymerase-1 (PARP-1) is involved in DNA base-excision repair and the …

    heid-diss Repository record

  18. Modulation of Transcription Factor Chromatin Association and Gene Transcription Program in Embryonic Stem Cell and Triple Negative Breast Cancer by Poly (ADP-Ribose) Polymerase 1

    Liu, Ziying2018

    Pages ix-xvi are incorrectly numbered as pages xiv-xxi.

    utswmed Repository record

  19. Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice

    Pandey, DheerajUniversité d'Ottawa / University of Ottawa2023

    Adenosine diphosphate (ADP) ribosylation is a post-translational modification dependent on the transfer of ADPr units from nicotinamide adenine dinucleotide (NAD+) on to a plethora of biomolecules (i.e., proteins, DNA, RNA, etc.) in response to physiological stressors (i.e., nutrient deprivation, …

    ottawa-retro Repository record

  20. Monosacchacharid-Konjugate von Inhibitoren der O6-Methylguanin-DNA Methyltransferase, der Poly-(ADP-ribose) Polymerase und des SWITCH Phänomens des HIV Hüllproteins gp120 : Synthese, biologische Aktivität und Struktur-Wirkungsbeziehungen

    Reinhard, JostUniversität Heidelberg

    In dieser Arbeit wurden acetyl- oder benzoylgeschützte Bromoalkyl-Glucoside synthetisiert, die zur Einführung von Glycosylalkylresten in verschiedene Moleküle geeignet sind. So wurden O6-substituierten Purine zu MGMT-Inhibitor-Glucosiden, eine Hydroxyphenyl-benzimidazol-Grundstruktur zu …

    heid-diss Repository record

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