Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"ADMA"”.
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Der Einfluss von diätetisch verabreichten Sojaisoflavonen auf den Homocysteinmetabolismus und die Endothelfunktion bei gesunden, postmenopausalen Frauen
… NO-Biosynthese asymmetrisches Dimethylarginin (ADMA) assoziiert. In-vivo senkt eine Östrogenbehandlung neben tHcy auch die ADMA-Spiegel und verbessert signifikant die Endothelfunktion. Hinsichtlich ihrer Wirkung als selektive Östrogenrezeptormodulatoren wird angenommen, dass Phytoöstrogene, …
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Blood-CNS transport mechanisms in pathophysiology and drug delivery
… into two main parts: <br/><br/>1. L-arginine and ADMA transport - Circulating levels of the cationic amino<br/>acid L-arginine and its endogenously produced homologue asymmetric<br/>dimethylarginine (ADMA) are in delicately poised equilibrium. Dysregulation of<br/>this balance has well-documented …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… ways to produce asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and monomethylarginine (MMA). These modifications are catalyzed by a family of nine protein arginine methyltransferases (PRMT1-9), which are of three types (I, II, and III). The majority of Type I enzymes …
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Effect Of Dimethylarginine Dimethylaminohydrolase In The Development Of Salt Sensitivity
… is through asymmetric dimethylarginine (ADMA), an endogenous NO inhibitor, which is largely metabolized by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). The activity of DDAH is impaired by oxidative stress, thereby permitting ADMA to accumulate thus resulting in further …
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Metabolomic Insights into the Pharmacological and Genetic Inhibition of Cyclooxygenase-2
… al., suggests that asymmetric dimethylarginine (ADMA) may serve as a mechanistic bridge between COX-2 inhibition and HF. However, the ADMA-COX-2 hypothesis was developed based on findings in a constitutive mouse model of COX-2 knock-out (KO), which is compromised by severe developmental …
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Nitric oxide in airway inflammation
… higher NOx and asymmetric dimethylarginine (ADMA) levels in A549 cells when compared with control media. The anti-oxidant, NAC pre-treatment partially reversed the elevated NOx levels but not the ADMA levels. This thesis is the first to report FENO and EBC NOx in COPD patients in an …
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Kinetic Characterization, Inhibition, and Activity-Based Protein Profiling of Protein Arginine Methyltransferase 1
… on to form asymmetrically dimethylated arginine (ADMA), while type II enzymes form symmetrically dimethylated arginine (SDMA). The predominant member of the PRMT family is PRMT1, as it is responsible for approximately 85% of the arginine methylation in mammalian cells. Since PRMT1 exhibits type I …
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Nuevas aportaciones al desarrollo de modelos QSAR/QSPR para la predicción de la mutagenicidad de contaminantes ambientales y su interacción con sustancias activas presentes en el medio
… que resaltar que sustancias como el TEGDMA, 1,6-ADMA, 1,8-ADMA, GMR, MEPC y 6-HHMA, predichos como mutagénicos, presentan valores de complejación superiores a los que presentan fármacos o componentes de los alimentos. Por lo tanto, estas sustancias podrían desplazar de sus complejos a fármacos o …
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Cardiovascular and renal responses to continuous, moderate and high-intensity interval exercise in mid-spectrum CKD.
… (ᶟ¯NT) asymmetric dimethyl arginine (ADMA), paroxonase-1 (PON-1), total antioxidant capacity (TAC), and creatinine. Urine samples were measured for epidermal growth factor (uEGF) and creatinine and the uEGF/uCr ratio was calculated as a marker of renal function. MDRD and CKD-EPI …
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Investigating the link between post-tuberculosis lung disease (PTLD) and circulatory biomarkers in a South African cohort
… and oxidative stress biomarkers, including ADMA, VCAM-1, VEGF, angiopoietin-1, TBARS, NT-pro-BNP, and cardiac troponin-I, in patients stratified by the number of previous TB episodes and the time since the last treatment. VEGF and angiopoietin-1 were significantly elevated (up to 6500-fold …
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Metabolomics of cerebrospinal fluids to identity novel biomarkers as a predictive tool for brain inflammatory conditions
… anthranilic acid/3-hydroxyanthranilic acid and ADMA/arginine in combination with neopterin can serve as a potential cerebrospinal fluid biomarker panel to predict neuroinflammation, particularly when routine tests and neuroimaging return a negative result in encephalitis patients. The emergence …
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The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes
… and non routine blood sampling (including plasma ADMA), PWV and an adipose biopsy were performed to determine resistance artery function and adipose AMPK activity. The effects of metformin, its closely related analogue phenformin and rosiglitazone were characterised in cultured human aortic …
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… It deposits asymmetric dimethylarginine (ADMA) marks on both histone and non-histone proteins. We performed a comparative proteomic screen with Pan-methylarginine (Rme2a) antibodies and identified that Nuclear Factor I-B (NFIB) is a major CARM1 substrate. <em>Nfib</em> and <em>Carm1</em> …
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Alimentäres Methionin und Hyperhomocysteinämie
… Methioninzufuhr ohne gleichzeitige Erhöhung von ADMA scheint also keine Verschlechterung der Gefäßfunktion bei Ratten zu bewirken. In diesem Punkt kann man von in anderen Modellen der Hyperhomocysteinämie gefundenen Resultaten keine Rückschlüsse auf die durch alimentäres Methionin verursachte …
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An Investigation of Epigenetic Mechanisms Driving The Biology of Head and Neck Squamous Cell Carcinoma
… upregulate PRMT1 and increase total levels of ADMA, PRMT1’s methylation product. Further, using TCGA data, I demonstrate patients expressing high levels of PRMT1 have significantly worse survival than patients expressing low levels of PRMT1. In the second project, I investigate the enhancer …
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The Influence of Obstructive Sleep Apnea Syndrome on Insulin Resistance, Metabolic Syndrome, and Endothelial Dysfunction in Young Men
… of OSAS. No differences in IL-6, TNF-á, ADMA, and expression of VEGFR2 were noted between any groups. No group or group x time interaction differences existed in regards to postocclusive reactive hyperemia responses. Conclusions: Young men with OSAS exhibit several unique anthropometric …