Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ADCY7"”.
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Using single-cell RNA sequencing to elucidate the biological basis of IBD and response to therapy
… in the adenylate cyclase (ADCY) genes ADCY3 and ADCY7, to understand the role of these IBD risk variants in immune cells. A trans-eQTL analysis performed in the immune cells of donors with carriage of the rare coding ADCY7 variant rs78534766 identified 65 unique trans-genes and enriched pathways …
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Understanding Inflammatory Bowel Disease using High-Throughput Sequencing
… including a low frequency missense variant in ADCY7 that approximately doubles the risk of ulcerative colitis. I resolve biological associations underlying several of these novel associations, including a number of signals associated with monocyte-specific changes in integrin gene expression …
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Methods Development in Inflammatory Bowel Disease
… increase risk of disease and two of the genes, ADCY7 and LSAMP, were found to be protective. In this study, I have identified novel genes and pathways for further IBD research. These methods have the potential to greatly increase the known genetic causes for IBD and other diseases by expanding …