Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"ADCC"”.
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC is exclusively mediated by the IgG Fcγ receptor (FcγR) CD16A, and many clinically successful therapeutic monoclonal antibodies (mAbs) utilize ADCC as a mechanism of action to eradicate tumor cells. However, CD16A binds IgG with low …
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The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
… antibody-dependent cellular cytotoxicity (ADCC) responses, which target virus-infected cells, may also be protective. This thesis uses deep sequencing, together with immune assays, to characterise HIV-1 Envelope evolution associated with both nAb and ADCC responses in early infection, and …
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Age-Dependency of Swine Antibody-Dependent Cellular Cytotoxicity Against Pseudorabies Virus-Infected Cells
… Antibody-dependent cellular cytotoxicity (ADCC) which involves both cell functions and antibodies might prove to be important in protection against PRV. Therefore, the age differences and age development of ADCC in pigs were studied. In this study it was demonstrated that ADCC activity in …
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Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination. This thesis characterises neutralizing response in two cohorts in Africa, and in a detailed study of one individual, elucidates the …
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Strategien zur Verstärkung der antikörpervermittelten Effektorzellaktivierung beim Multiplen Myelom
… zellvermittelte Zytotoxizität (ADCC) und die antikörperabhängige zelluläre Phagozytose (ADCP) leisten nachweislich einen wichtigen Beitrag zur Effektivität des CD38-Antikörpers Daratumumab. Im Rahmen dieser Arbeit wurden Strategien zur Verstärkung dieser Wirkmechanismen …
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Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
… antibody-dependent cellular cytotoxicity (ADCC), or killing of HIV-infected cells, can reduce HIV pathogenesis. Within the setting of breastfeeding transmission, our group previously demonstrated that passively-acquired ADCC correlates with improved survival of infants who acquire HIV, …
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NK Cells and Their Role in Disease and Cancer Treatment
… antibody dependent cell mediated cytotoxicity (ADCC) and how deficiencies in ADCC play a role in human disease. We will also cover improvements we have made to quantifying and measuring ADCC through an improved chromium 51 assay. Then we will look at chronic fatigue syndrome (CFS) and the role …
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The Activity of Breast Milk and Monoclonal HIV-specific Antibodies in Mother-to-Child Transmission
… antibody dependent cell-mediated cytotoxicity (ADCC) were detected in the BMS from all 19 women. BMS ADCC activity was associated with envelope-specific IgG titers (p = 0.014) and was inversely associated with infant infection risk (p = 0.039). Our data indicate that BMS has limited HIV …
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Comparing high-throughput methods to measure antibody dependent cellular cytotoxicity during HIV infection
… cell antibody-dependent cellular cytotoxicity (ADCC), there has been considerable interest in measuring alternative roles for HIV-specific binding antibodies. The aim of this MSc dissertation was to optimise and compare two high-throughput flow cytometry based approaches - the GranToxilux and …
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Discerning the Mechanism of Gamma Delta T Cell-Mediated Damage in Multiple Sclerosis: the Potential Role of Antibodies in Disease Pathogenesis
… via antibody-dependent cellular cytotoxicity (ADCC). We postulated that if there were also relevant and detectable antibodies in MS patients that might engage these FcR-bearing γδ T-cells then this might be a purported mechanism of neuro-axonal injury. A search for antibodies specific to axonal …
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Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia
… antibody dependent cellular cytotoxicity (ADCC) with mouse effector cells. The anti-tumor activities of all three MAbs were identical in SCID mice xenografted with human B cell tumors. However, the chimeric tetravalent MAb has a higher binding affinity and a longer half-life of dissociation …
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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer
… antibody-dependent cell-mediated cytotoxicity (ADCC) in neuroblastoma. However, the underlying cellular mechanisms in these processes are not fully understood. In my thesis research, I sought to gain a deeper understanding of the molecular and cellular changes within NK cells that occur in the …
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Design, Synthesis And Biological Evaluation Of Small Molecules That Inhibit Hiv-1 Entry And Sensitize Hiv-1 Infected Cells To Immune Responses
… to antibody-dependent cellular cytotoxicity (ADCC). The first part of my thesis describes the development of a late-stage derivatization strategy for the synthesis of 1,2,5,7-tetrasubstituted aminoindane small molecule CD4mc and the corresponding biological evaluation. The second part …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… and antibody dependent cellular cytotoxicity (ADCC) of human NK cells. In this study, I show that Vav-1 is also expressed in murine NK cells. Vav-1-/- mice had normal numbers of splenic NK cells, and these displayed a similar expression profile of NK cell receptors as cells from wild type mice. …
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Potentiating Antibody Therapy by Targeting Complement on Cancer Cells
… (CDC), antibody dependent cytotoxicity (ADCC), apoptosis and phagocytosis on Day 2 CLL cells. To test CDC, Day 2 CLL and previously treated CD20+ cell lines were incubated with anti-C3d mAb and normal human serum and stained for cell death. Similarly, ADCC was tested by coincubating Day 2 …
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The Effects of Levamisole, CORYNEBACTERIUM PARVUM, and Unblocked Lymphocytes on Mice Injected with Herpes Virus Type 2-transformed Cells
… antibody-dependent cell-mediated cytotoxicity (ADCC) test, the blocking factor (BF) assay and the cytolytic T-lymphocyte (CTL) test. The lymphocyte transformation test using phytohemagglutinin, a T-cell mitogen, was also performed at the time of sacrifice, using mouse spleen cells.</p> …
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Dynamics of the HIV-1 Latent Reservoir
… reservoir reseeding. I also examine the role of ADCC activity in preventing re-seeding of the latent reservoir and demonstrate that ADCC activity does not correlate with change in HIV DNA reservoir size following treatment interruption. Finally, I demonstrate that the HIV DNA reservoir is …
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The Design And Synthesis Of Inhibitors Of Hiv-1 Viral Entry And Photoaffinity Labeled Probes For Structural Elucidation Of The Hiv-1 Env
… mediated neutralization and elimination (ADCC). Secondly, HIV-1 infection inhibition and lysis of HIV-1 virions has been accomplished via the design, synthesis and validation of a family of small molecule “Dual-Action Virucidal Entry Inhibitors” (DAVEIs). These compounds, comprised of a …
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Sectoral dynamics of financial co-integration between BRICS and developed stock markets
… 2006 to December 2017. The study applies the ADCC GJRGARCH model to estimate the time-varying correlations across the nine countries within each sector and across sectors within each country, and assesses the conditional correlation dynamics during each of the phases of the three crisis …
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A new approach to calculate and forecast dynamic conditional correlation - the use of a multivariate heteroskedastic mixture model
… values of conditional returns. Note that, the ADCC skew-t and AGDCC skew-t model analyzed in this research are both new to the financial literature
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