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Showing 1 to 20 of 20 for “"ADAR"”.
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Characterizing the RNA Editing Specificityof ADAR Isoforms and Deaminase Domains In Vitro
<p>Adenosine deaminases acting on RNA (ADARs) convert adenosine-to-inosine in double stranded RNA. Selectivity of editing sites depends on the sequence of the RNA as well as the secondary structure. Identification of sites of ADAR editing by editome analysis is skewed due to the different abundance …
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The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
<p>Adenosine deaminase acting on RNA (ADAR) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing is an important post-transcriptional mechanism to prevent recognition of endogenous RNA by MDA5, a cytosolic RNA sensor. Activation of MDA5 by viral RNA can stimulate …
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Scale and texture in digital image classification
… measure are often large. Experiments with ADAR 1-meter data suggest that windows of 50 to 300 meters are necessary. Small windows are required to minimize edge effects. This is inherently contradictory as windows used to produce stable texture measures also produce a large edge …
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THE ROLE OF ADARS-INTERACTING RNA HELICASES IN SHAPING THE RNA EDITOME IN CANCER
… (A-to-I) RNA editing, primarily catalysed by the ADAR family of proteins, is oftentimes dysregulated in cancers. However, the regulatory mechanisms controlling editing frequency in cancer cells remain largely elusive. Besides factors affecting the expression and activity of ADAR proteins, …
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Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
… adenosine by adenosine deaminases acting on RNA (ADAR). ADAR editing activity is known to play a key role in modulating the host cell’s immune response to RNA. Here, we specifically study the effect of the presence of inosine in RNA by generating an inosine-containing reporter mRNA sequence. We …
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Reading Between the Strands: Deciphering Double Stranded RNA-Based Immune Responses in Mosquito-Virus Interactions
… investigated adenosine deaminase acting on RNA (ADAR), a conserved dsRNA-binding protein. Using both knockdown and overexpression approaches, we found that each reduced virus replication and dampened immune gene expression, suggesting that ADAR levels must be tightly regulated to balance …
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Automatic selection of optimal window size and shape for texture analysis
… and scales of data, including SPOT, SIR-C, and ADAR, were used to test the robustness of this program.;The results from this research indicate that the addition of texture can improve classification accuracy, especially in land cover regions with high local variability among the pixels. The 21 x …
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Evaluation of the use of remotely sensed images to speciate mixed Appalachian forests
… the Airborne Data Acquisition and Registration (ADAR) System 1000, and to determine the optimal spatial resolution and the optimal scale of the acquired images. Digital images of a 200-ha area in west central West Virginia were acquired for the study.;The first objective of the study was to …
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A-to-I RNA Editing in Human Cells
… modify RNA, adenosine deaminase acting on RNA (ADAR) is a type that catalyzes adenosine-to-inosine editing on double-stranded RNA molecules to regulate cellular responses to endogenous and exogenous RNA. Of the three ADAR homologs in humans, dysregulation of ADAR1 editing due to inherited …
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Developing Nucleic Acid-Based Sensors and Actuators
… in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert target hybridization into a translational output. This system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. This topology confers high dynamic range, low background, minimal …
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Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
… mediated by the proteins of the APOBEC1 and ADAR families, respectively. APOBEC1 has been fully characterized in its role of editing the Apolipoprotein B (ApoB) transcript in the intestine, where the C to U modification changes a glutamate codon to a stop codon, creating a smaller version of …
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RNA-level controllers for programmable gene expression in mammalian cells
… in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert target hybridization into a translational output. This system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. This topology confers high dynamic range, low background, minimal …
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Unsupervised discovery and validation of affective engagement states using synchronized EEG and eye-tracking during digital learning
This study explores affective engagement states in digital learning environments using synchronized EEG and eye-tracking data. EEG signals were collected from frontal channels and processed using sliding windows to extract band-power features. Frontal Alpha Asymmetry (FAA; log alpha power …
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The Regulatory Capacities of Motivational Constructs: An examination of Academic Motivation and Self-Regulation Toward Academic Success in Favorite and Least Favorite Classes
<p>One-hundred and seventy-seven high-school students and two-hundred responded to a survey assessing their motivation (goal orientations, expectancies, and values), self-regulation (cognitive, behavior, and emotion), learning processes, academic behaviors, and grades in the favorite and least …
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Hybrid-search and storage of semi-structured information
Given today's tangle of digital information, one of the hardest tasks for computer users of information systems is finding anything in the mess. For a number of well documented reasons including the amazing growth in the Internet's popularity and the drop in the cost of storage, the amount of …
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Optimal and heuristic solutions for the single and multiple batch flow shop lot streaming problems with equal sublots
This research is concerned with the development of efficient solutions to various problems that arise in the flow-shop environments which utilize lot-streaming. Lot streaming is a commonly used process of splitting production lots into sublots and, then, of scheduling the sublots in an overlapping …
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Between rejection and coping: the consolidation of turkish identity in Germany
… to the shift in diaspora governance of Turkey (Adar, 2019; Arkilic, 2021; Hatay & Tziarras, 2019b). As expected, we found that ethnonational identification of Turkish postmigrants is more sensitive to the subjective components of rejection (e.g., appraisal of threat & causal attribution) rather …
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Next-generation sequencing analysis and RNA editing in human brain and glioma
… between expression of the editing enzymes ADAR, ADARB1, and ADARB2 and editing profiles in both healthy and diseased states of the brain. Furthermore, I identify many differentially edited bases across normal brain and gliomas that have not previously been characterized. My results …
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Molecular biology of segment 8 of the influenza A virus genome
… induces the re-localisation of cellular protein ADAR1 to the nucleolus. ADAR1 is an RNA-editing enzyme that converts adenosine residues to inosines, which are then interpreted by cellular machinery as guanosine. There is a potential that ADAR1 activity may affect the influenza virus genome; …
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Spartina Alterniflora Productivity and Salt Marsh Stability Relative to Marsh Platform Elevation
<p>Standing biomass of <em>Spartina alterniflora</em> Loisel. (<em>Spartina</em>) has been shown to correlate with the relative elevation of the sediment surface and anomalies in mean sea level. Aboveground biomass, stem density, stem height and percent organic nitrogen were measured as a function …