Global ETD Search
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Showing 1 to 11 of 11 for “"ADAMTS13"”.
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ADAMTS13 Activity in Dogs with Chronic Enteropathies
… with a thrombospondin type 1 motif, member 13 (ADAMTS13), a von Willebrand factor (vWF) cleaving enzyme, and increased circulating vWF. The primary aim of this study is to assess plasma ADAMTS13 activity, vWF antigen (vWF:Ag) concentration, and vWF collagen binding activity (vWF:CBA) in dogs …
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Studies of ADAMTS13 expression and activity in the kidney
… and aggregation at sites of vascular injury. ADAMTS13 is the sole physiological VWF-cleaving protease, thus regulating the size of thrombus growth. Dysfunctional ADAMTS13 leads to thrombotic thrombocytopenic purpura (TTP), which is either due to mutations (congenital TTP) or auto-antibodies …
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Determination of ADAMTS13 Susceptibility in Type IIA von Willebrand Disease
… cascade. vWF is cleaved by the metalloprotease ADAMTS13, regulating the multimers size, which hinders vWF’s ability to function properly. The three main types of vWD —Type I, II, and III— are not well defined, and as a result are all similarly treated with plasma-derived vWF replacement therapy. …
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Plasma ADAMTS13 activity in dogs with severe thrombocytopenia and presumed immune thrombocytopenia
Background: In humans, deficiency of plasma ADAMTS-13, a von Willebrand factor cleaving enzyme, is an important cause of thrombocytopenia in immune thrombotic thrombocytopenic purpura (iTTP). This disease can be difficult to differentiate from immune thrombocytopenia (ITP) in people. Further …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… elevated levels of VWF, which is cleaved by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). The ADAMTS13-VWF axis was investigated in 208 CTEPH patients including its relationship to ABO blood groups and ADAMTS13 genetic variants. Plasma ADAMTS13 …
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The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype
… of the von Willebrand factor cleaving protease (ADAMTS13). Over 100 mutations have been identified in ADAMTS13 yet, in some cases, these mutations in congenital TTP alone do not explain the disease phenotype, particularly in late-onset congenital TTP. One aim of this study was to analyse the …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential complication of the aberrant activity of these …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement, and its pathophysiological implications for human diseases. Using assays of ex-vivo serum-induced C3 and C5b-9 deposits on endothelial cells we documented …
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PATHOPHYSIOLOGY OF VON WILLEBRAND FACTOR IN BLEEDING AND THROMBOSIS
… aimed to evaluate whether the reduction of ADAMTS13 activity or the alteration of ADAMTS13-VWF equilibrium may play a role in DVT pathogenesis. In Chapter 7, we performed a case-control study to evaluate the association between ADAMTS13, VWF, and FVIII plasma levels and DVT. We showed that a …
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Trends in clinical presentation and treatment outcomes in a South African TTP cohort
… thrombotic microangiopathy, HIV-associated TTP, ADAMTS13, treatment outcomes, plasma infusion, plasma exchange.
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… VWF fibers were non-amyloid and resistant to ADAMTS13 and tissue plasminogen activator. Factors XIIa and XIa were captured in VWF fibers during aggregation, and could initiate fibrin formation on VWF. When whole blood was perfused over VWF fibers, platelets rolled, bound, and activated in a …