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Showing 1 to 2 of 2 for “"ADAMTS-13"”.
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement, and its pathophysiological implications for human diseases. Using assays of ex-vivo serum-induced C3 and C5b-9 deposits on endothelial cells we documented …
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Plasma ADAMTS13 activity in dogs with severe thrombocytopenia and presumed immune thrombocytopenia
Background: In humans, deficiency of plasma ADAMTS-13, a von Willebrand factor cleaving enzyme, is an important cause of thrombocytopenia in immune thrombotic thrombocytopenic purpura (iTTP). This disease can be difficult to differentiate from immune thrombocytopenia (ITP) in people. Further …