Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"ADAMTS"”.
-
The role of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-‐15 (ADAMTS-‐15) in Breast Cancer
… Metalloproteinase with thrombospondin motifs (ADAMTS) family are candidate tumour suppressors, including ADAMTS-15. In the context of breast cancer relatively high levels of ADAMTS-15 expression had previously been associated with increased relapse free survival. However the functional …
-
Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the mechanism through which VWF modulates complement, and its pathophysiological implications for human diseases. Using assays of ex-vivo serum-induced C3 and C5b-9 deposits on endothelial cells we documented …
-
Plasma ADAMTS13 activity in dogs with severe thrombocytopenia and presumed immune thrombocytopenia
Background: In humans, deficiency of plasma ADAMTS-13, a von Willebrand factor cleaving enzyme, is an important cause of thrombocytopenia in immune thrombotic thrombocytopenic purpura (iTTP). This disease can be difficult to differentiate from immune thrombocytopenia (ITP) in people. Further …
-
Exploring issues for a cartilage degradation model
… of glycosaminoglycan degradation induced by ADAMTS using dGEMRIC and DMMB assays. The mean uniaxial degradation rate for 20nM ADAMTS was 0.17 mm/day ± 0.08 (1 [delta], n = 4). The shape of the diffusion front was mostly flat, with attributable factors such as vascular structures affecting the …
-
Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… domain with thrombospondin motifs, ADAMTSs) play an important role in cartilage degradation. The collagenases (MMP-1 and MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5) are implicated in the development of OA because of their ability to degrade type 2 collagen and aggrecan. This …
-
Vergleichende Untersuchungen zum Effekt von Interleukin-17A auf den Meniskus und hyalinen Gelenkknorpel im Rindermodell
… matrix-degradierende Enzyme (MMP-3, -13 und ADAMTS-4) und gewebespezifischer Kollagene (Kollagen-1 und-2) (qRT-PCR) und lichtmikroskopisch die Apoptoserate eruiert. Zusätzlich wurde das Gewebe lichtmikroskopisch mit einer Toluidinblaufärbung und der Aggrekanabbau mittels NITEGE-Immunfärbung …
-
Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… revealed five distinct groups. TIMP-3 and ADAMTS-5, MMP-l and IGF-2, and IGF-1 and Collagen II, were all robustly co-expressed under all conditions tested. In comparing gene expression levels to previously measured aggrecan biosynthesis levels, aggrecan synthesis is shown to be …
-
Left, Right, and Center: A Novel Midline Barrier Separates Asymmetric Extracellular Matrix During Intestinal Development
… wall, and that this versican is cleaved by ADAMTS enzymes. ADAMTS enzymes create bioactive fragments of versican which have diverse impacts on development. While the role of versican and its cleavage in gut development is still unknown, my characterizations and preliminary experiments with …
-
ADAMTS1 is a promoter of metastatic cell behaviour in mammary cancer cells.
… that play a major role in ECM remodelling. The ADAMTS metalloproteinase family has been implicated in the re-organisation of the tumour microenvironment associated with cancer development and metastatic disease progression. Of the 19 ADAMTS proteases, considerable attention has been devoted to …
-
In vitro models for injurious compression of bovine and human articular cartilage
… also characterize the activity and activation of ADAMTS-4 (aggrecanase-1) in the cartilage tissue, one of the major enzymes responsible for proteoglycan degradation. These results may help to identify some of the interactions between mechanical stimuli, joint tissue damage, and chondrocyte …
-
Identificación de interacciones proteicas de ADAMTS19 en un contexto ovárico
Las proteínas ADAMTS (desintegrinas y metaloproteinasas con motivos trombospondina) han sido asociadas a diversos procesos biológicos entre ellos el desarrollo folicular y la ovulación. Algunos miembros son considerados proteínas huérfanas debido a que no se han descrito sus sustratos específicos …
-
Secuenciación de siguiente generación en mujeres afectadas por falla ovárica prematura no sindrómica para la identificación de nuevos genes etiológicos de la enfermedad y estudio funcional de la mutación p.thr943ile en adamts19
… presentaba una mutación no sinónima en el gen ADAMTS19 (c.2828C>T, p.Thr943Ile). La proteína ADAMTS19 se clasifica dentro de la familia ADAMTS como huérfana ya que no se ha identificado su sustrato. Mediante el sistema de doble hibrido en levaduras se buscó identificar las potenciales proteínas …
-
Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… recruitment. Furthermore, miR-133a-3p promoted ADAMTS-1 expression under TNF-α stimulation, supporting ECM remodelling, while miR-133a-3p also induced ICAM-1 expression in response to TNF-α, enhancing leukocyte adhesion. Conclusion: miR-133a regulates endothelial responses during inflammation. …
-
Slc39a8/zip8 Influences Complex Traits By Regulating Metal Ion Metabolism
… factor 1 transcriptional activity, decreased Adamts metalloproteinase transcription, and impaired extracellular matrix degradation that has been implicated in noncompaction. Thus my dissertation reveals the mechanism in which Slc39a8 mediates Mn transport in vivo and demonstrates that Slc39a8 …
-
Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… The expression of other genes in the array like, ADAMTS-1, E-Selectin, and VCAM-1, was affected by lack of PMCA4, but only when cells were stimulated with VEGF. Examination of changes in the expression of these genes in PMCA4-silenced HUVEC or HDMEC showed differences indicating that PMCA4 might …
-
Developing an astrocyte-selective AAV-ADAMTS4 gene therapy to promote repair after spinal cord injury
… metalloproteinase with thrombospondin motifs-4 (ADAMTS4) is a human enzyme that catalyses the proteolysis of CSPG protein cores. Infusion of ADAMTS4 into the damaged spinal cord was previously shown to improve functional recovery after SCI; however, this therapy is limited in its enzyme form. …
-
Mechanobiology of the nucleus pulposus: The effect of hydrostatic pressure and glucose deprivation on nucleus pulposus cell sub‐populations
… in a decrease in aggrecan, collagen II and ADAMTS‐5 gene expression in MNP cells. NC cells did not alter their gene expression response to the combined pathological insult. Together these findings show that NC cells are the major producers of proteoglycans, and are resistant to mechanical …
-
Adamts9 is critical for the development of primary ovarian follicles
Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. Knockouts of ADAMTS9 in mice and AdamTS-A in Drosophila melanogaster are embryonic …
-
Subclinical Phenotypes and Genotypes in Parents of Children with Non-Syndromic Cleft of Lip and/or Palate
… an association with SNP (rs7972295) in the ADAMTS 20 gene for the father-male control group data.<b><br/></b><b><br/></b><b>Conclusion</b>: Non-cleft parents have distinctive facial morphological features and different dental width measurements, but only tooth 35 width - gene association was …
-
Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
… die IGFBP-6 Metalloprotease zu Familie der ADAM/ADAMTS gehört.MDCK-Zellen sezernieren IGFBP-4 und -6 Proteasen bevorzugt zur basolateralen Seite, während IGFBPs als Resultat spezifischer intrazellulärer Sortierungsprozesse hauptsächlich von der apikalen Seite abgegeben werden. MDCK-Zellen, die …
Page 1 of 2