Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"AD mouse models"”.
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A Multi-Faceted Approach to the Alzheimer’s Disease Proteome: From Human to Mouse Models
… is the central hallmark of Alzheimer’s disease (AD) and related dementias (ADRD). We analyzed the dementia with Lewy bodies disease (DLBD) proteome, a disorder also associated with amyloid pathology, and compared to the AD proteome, identifying conserved alterations in amyloid pathology and …
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A New Role for Beta-Amyloid in Alzheimer's Disease: Initiation of Thrombotic and Inflammatory Processes Via Coagulation Factor XII and Fibrinogen
<p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no effective therapies. While abundant genetic, histological, and experimental evidence links the beta-amyloid (Aβ) peptide to disease onset and progression, the mechanisms behind neuronal dysfunction in AD are not …
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Epigenetic regulation by 5-hydroxymethylcytosine in atopic dermatitis and psoriasis and its implications for epidermal stem cell behavior
… a healthy skin barrier by replenishing dead keratinocytes lost during daily turnover, injury, or pathological disturbances. In atopic dermatitis (AD) and psoriasis (PS), there is marked psoriasiform hyperplasia of the epidermis, suggesting a hyperproliferation of keratinocytes and …
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Multi-sensory gamma stimulation ameliorates Alzheimer's-associated pathology and improves cognition
… Hz) have been observed in humans and animal-models of Alzheimer's disease (AD). Examining the relationship between gamma oscillations and disease pathology is a significant problem in neuroscience. Recent work using a non-invasive light flicker at 40 Hz, termed Gamma ENtrainment Using Sensory …
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Neuronal Protection by a Novel C-terminal Hsp90 Modulator
Alzheimer's disease (AD), like most neurodegenerative disorders, is characterized by accumulation of misfolded and aggregated proteins, indicating that the protein quality control machinery is compromised. Enhancing the activity of molecular chaperones such as the `heat shock' proteins (Hsp's) that …
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PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model
… a quintessential feature of Alzheimer’s disease (AD) and AD mouse models. We and others have previously reported the peroxisome-proliferator activated receptor gamma (PPARγ) agonist rosiglitazone improves hippocampus-dependent cognitive deficits in some AD patients and ameliorates deficits in the …
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The Effect of Early Dietary Intervention on Alzheimer's Disease-Related Pathology and Cognitive Function in Mice
<p>Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits, neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss. AD is a multifactorial disease, and lifestyle factors, including diet, are likely associated with the development of AD …
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Examinations into the Calcium Hypothesis of Alzheimer's Disease
Alzheimer's disease (AD) is devastating to the patient, their family and friends, and represents a significant fiscal burden to our society. Currently available therapeutics provide only mild symptomatic relief and do not alter the course of the disease. Developing the next generation of disease …
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Integrated computational and experimental analysis of non-neuronal cell molecular mechanisms contributing to Alzheimer's disease progression
Alzheimer’s disease (AD) is the most common form of dementia, characterized by symptoms such as memory loss and language disruption. Amyloid beta-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs) are defining characteristics of AD. However, plaques and NFTs …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… and dementia, particularly Alzheimer’s disease (AD). While this interaction is not completely understood, clinical studies suggest that both hyper- and hypoinsulinemia are associated with an increased risk for developing AD. Indeed, insulin signaling is altered in post-mortem brain tissue from AD …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
<p>Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and …
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The Neuroprotective Effects of Exercise Against Menopause Induced Alterations in Alzheimer’s Disease Neuropathogenesis
<p>Alzheimer’s Disease (AD) disproportionately impacts women; and the loss of ovarian hormones during the perimenopausal transition has been identified as a sex-specific risk factor. Previous studies have shown that the ovarian hormone, estrogen, utilizes its neuroprotective effects on tissues in …
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Investigation of Monoaminergic Neurotransmitter Systems as a Method to Study Alzheimer's Disease-Related Neurodegeneration
Alzheimer’s disease (AD) is the most common neurodegenerative disease and leading cause of dementia currently afflicting 5.4 million people in the United States. Memory impairment and cognitive dysfunction are the most recognized clinical manifestations of AD, however, disturbances in vision, …