Global ETD Search
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Showing 1 to 10 of 10 for “"AChRs"”.
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Ανασυνδυασμένα τμήματα του ανθρώπινου νικοτινικού υποδοχέα για την κατανόηση των παθογενετικών μηχανισμών της βαριάς μυασθένειας
Οι υποδοχείς της ακετυλοχολίνης (AChRs) είναι διαμεμβρανικές πρωτεΐνες ενεργοποιούμενες με τη δέσμευση της ακετυλοχολίνης (ACh). Με κριτήρια, όπως η χημική συγγένεια που εμφανίζουν για σηματοδότικά μόρια και οι φαρμακολογικές τους ιδιότητες, ταξινομούνται στην ομάδα των νικοτινικών AChRs και στην …
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Efecto de las variaciones en los niveles de lípidos sobre el tráfico y propiedades del receptor de acetilcolina nicotínico en células CHO
… por acción de esta droga, el número de AChRs presentes en la membrana plasmática de células CHO-K1/A5 sufre una drástica disminución (46%), con un aumento concomitante en el número de receptores intracelulares. Dichas variaciones se produjeron por inhibición del tráfico exocítico de la …
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Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
… resulting in the possible reorganization of AChRs. In vivo, HRG was found to partially restore NMJ formation and increase axonal and muscle integration in the NMJ. This study provides evidence that a mechanism of action for the positive effects of HRG on the dystrophic phenotype in mdx mice …
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Caracterización de la interacción entre el anticonvulsivo Lamotrigina y el receptor de acetilcolina nicotínico
… comprobar que la LTG interacciona con los AChRs, ejerciendo un efecto bloqueador de canal abierto cuando es co-aplicada con el agonista natural ACh (1 mM). Dicho efecto es proporcional a la concentración de LTG aplicada. En una segunda etapa, analizamos si la LTG ejercía efectos a nivel …
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ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ
… ANTIBODIES WHICH ARE ATTACHED ON THE MEMBRANE ACHRS CAUSING FOCAL LYSIS OF THE ACHR-BEARING MEMBRANES. ANTI-ACHR ANTIBODIES IN MG SERA ARE HETEROGENEOUS. IDENTIFICATION OF THE ANTI-ACHR SPECIFICITIES AND CHARACTERIZATION OF THEIR PATHOGENIC ROLE IS IMPORTANT FOR THE UNDERSTANDING AND TREATMENT …
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Neuromuscular Junctions in Androgen Sensitive Muscles: A Model for Synaptic Plasticity
… I measured acetylcholine receptor number (AChRs). AChR number was androgen-sensitive in both the syrinx and levator ani, decreasing after castration of males, and increasing in response to treatment with testosterone. I performed a detailed examination of the time course of the effect of …
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DEVELOPMENT OF A TISSUE ENGINEERED SKELETAL MUSCLE REPAIR CONSTRUCT FEATURING BIOMIMETIC PHYSICAL, CHEMICAL, AND MECHANICAL CUES
… exhibited clusters of acetylcholine receptors (AChRs). When agrin was presented bound to the surface of a carrier microparticle, this response was spatially restricted to areas of cell – microparticle contact. Moreover, AChR clusters were observed from 16 – 72 hours after treatment when Z+ agrin …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… (ACh). Two types of acetylcholine receptors (AChRs) have been suggested to be located on hair cells (HCs). They were nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and pharmacological studies have shown evidence of mAChR located on the HCs, …
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An investigation into the desensitization of neurotransmitter gated ion channels — functional relevance, impact on ganglionic receptor function, and structural insights
… unusual desensitization properties of the α3β4 AChRs, receptors that are the primary mediators of fast-synaptic transmission in the autonomic ganglia. Previously, it had been proposed that oxidation of an intracellular cysteine is fundamentally critical in the mechanism of this unusual …
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The Steroid Sulfatase Inhibitor (p-O-Sulfamoyl) - Tetradecanoyl Tyramine (DU-14) Enhances Memory Retention in Passive Avoidance in Rats with Hippocampal Cholinergic Deficit
Neurosteroids, such as dehydroepiandrosterone sulfate, (DHEAS) are steroidal compounds synthesized within the central nervous system that modulate its function. Among the effects associated with sulfated neurosteroids is the enhancement of memory. Previous studies have demonstrated that altering …