Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ACSS2"”.
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Investigating the role of ACSS2-mediated acetyl-CoA metabolism on EGFR-PI3K-PKB signalling
… synthetase short chain family member 2 (ACSS2) is responsible for acetate-dependent synthesis of acetyl-CoA. The objective of this study was to investigate the potential impact of ACSS2-mediated acetyl-CoA on EGFR-PI3K signalling, shedding light on the regulatory roles of metabolism in …
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Dual Mechanisms Regulating Alpha Subunit-Specific Activity in Hypoxia-Inducible Factor Signaling
… acetylation was signaled. Our studies revealed ACSS2, an acetyl CoA synthetase, as the source of acetyl CoA required for HIF-2α complex formation with the acetyltransferase CBP, subsequent HIF-2α acetylation, and target gene activation. The ACSS2 substrate acetate is produced during hypoxia, and …
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COMBINATORIAL EFFECTS OF DIET-MICROBIOTA INTERACTIONS ON HOST METABOLISM
… modulate tumor biology through the host enzyme ACSS2, which converts acetate to acetyl-CoA—a substrate for lipid synthesis and histone acetylation. Loss of ACSS2 in human CRC tumors correlated with increased expression of metastasis-related genes, including those involved in …
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CHARACTERISING A ROLE FOR ACETYLCOENZYME A SYNTHETASE 2 IN THE REGULATION OF AUTOPHAGY
… synthesis, catalysed by AcCoA synthetase 2 (ACSS2), in the regulation of autophagy.
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
… activity of the enzyme acetyl-CoA synthetase 2 (ACSS2) in vitro. Detecting downstream metabolites in vivo can be challenging due to their relatively low concentrations. Here, I showed that semi-heavy water (HDO) labelling from 2H-labelled acetate can be used as a surrogate marker of fatty acid …
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Impact of metabolic pathways on ER+ metastatic breast cancer therapy response
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01