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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"ACLY"”.
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IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
Introduzione e scopo: ATP citrato liasi (ACLY) è un enzima chiave del metabolismo lipidico, responsabile della conversione di acetil-CoA citosolico a partire dal citrato mitocondriale. L’acetil-CoA generato costituisce un precursore fondamentale sia per la de novo sintesi degli acidi grassi, …
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MOLECULAR REGULATION OF ATP-CITRATE LYASE
ATP-citrate lyase (ACLY) is the major source of glucose-derived acetyl-CoA outside the mitochondria and is an attractive therapeutic target for metabolic disorders and cancer. In the cytosol, acetyl-CoA is used for lipid synthesis and is also the essential substrate for protein acetylation. In the …
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Acetyl-CoA metabolism and human trophoblast differentiation
… investigates the role of ATP citrate lyase (ACLY), an enzyme that links glucose metabolism to histone acetylation by producing acetyl-CoA, a substrate for epigenetic modifications. The hypothesis was that ACLY is essential for maintaining trophoblast stemness by providing a localised supply …
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Effect of Morinda citrifolia (Noni)-Enriched Diet on Hepatic Heat Shock Protein and Lipid Metabolism-Related Genes in Heat Stressed Broiler Chickens
… carboxylase alpha (ACCα), and ATP citrate lyase (ACLY). HS down-regulated the hepatic expression of lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (LIPC), but up-regulated adipose triglyceride lipase (ATGL). Although it did not affect growth performance, Noni supplementation regulated …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
… alpha (ACACA or ACC1) or ATP citrate lyase (ACLY) protected cancer cells from hypoxia-induced apoptosis. Furthermore, the loss of ACLY or ACC1 reduced the levels and activities of the oncogenic transcription factor ETV4. Silencing ETV4 also protected cells from hypoxia-induced apoptosis and …
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Atp-Citrate Lyase Links Cyclin E to Cellular Metabolism In Breast Cancer
… this methodology, we found ATP-citrate lyase (ACLY) as a novel interacting protein of LMW-E (T1) in the cytoplasm. ACLY is a 125kDa homotetrameric enzyme that catalyzes cytoplasmic citrate to acetyl-CoA and oxaloacetate in the <em>de novo</em> lipogenesis pathway. End products of this pathway …
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… significantly higher level of ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC) and FAS than the normal non-tumorigenic stem-like cells obtained from MCF10A. The result was also confirmed by qRT-PCR and Western blot as well as in clinical specimens of DCIS by immunohistochemistry. In the next …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… identified novel players such as integrin αv, Acly, ADNP and ZIP7. Notably, small molecule inhibitors and neutralising antibodies confirmed a previously unappreciated, but critical role of αv, in combination with integrin β3, in TH2 cell differentiation. The generation of mice with a …
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Metabolism and gene expression during diapause in athropods
… upregulated in pre-diapause embryos, and ACLY and Capthesin B-like protease are downregulated compared to non-diapause embryos. The need for genes upregulated in pre-diapause embryos appears to be transient as these genes are substantially downregulated 10 d after diapause entry. Taken …
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CHARACTERISING A ROLE FOR ACETYLCOENZYME A SYNTHETASE 2 IN THE REGULATION OF AUTOPHAGY
The important role of the central intermediary metabolite acetyl-coenzyme A (AcCoA)for several anabolic and catabolic pathways is well characterised. However, the role of AcCoA as the only known donor of acetyl groups for protein acetylation in regulation of enzyme activities, protein complex …