Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"ACE inhibitor"”.
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The in vivo characterisation of a C-domain specific ACE inhibitor
The ACE protein is a zinc-dependent dipeptidyl carboxypeptidase comprised of two homologous domains termed the C- and N-domain. The C-domain is primarily responsible for the catalytic production of Ang II, while the tetrapeptide acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is predominantly cleaved …
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Genetic and biochemical analysis of ACE inhibitor-induced angioedema in black and coloured South Africans
Angiotensin converting enzyme inhibitors (ACEi) are routinely used as first line treatment for hypertensive patients because of their protective effects against heart and kidney disease. Despite their clinical benefits, ACEi used is associated with adverse side effects such as life threatening …
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Functional Capacity Outcomes following Coronary Artery Bypass Graft Surgery
… limitations, and angiotensin converting enzymes (ACE) inhibitor drugs as significant predictors (R2 = 0.50, N = 63). When an RER of 1.1 was achieved during the treadmill test, myocardial infarction (MI) and if so, the length of time lapse from the MI, chronic heart failure, lipid lowering drugs, …
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Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure
… developed molecules which have dual enzyme inhibitor activity. Omapatrilat, a molecule which inhibits both angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP), and SLV 306 (active metabolite KC12615) a compound with both NEP and endothelin converting enzyme (ECE) inhibiting …
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Inhibitoren des Angiotensin Converting Enzyme (ACE) in hypoallergenen Säuglingsnahrungen
… übernimmt das Angiotensin Converting Enzyme (ACE) eine wichtige Rolle bei der Blutdruckregulierung. ACE spaltet das biologisch inaktive Angiotensin I zum vasokonstriktorisch wirksamen Angiotensin II, was zu einem Anstieg des Blutdruckes führt. Tier- und Humanstudien zeigten, dass die Aufnahme …
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A systematic review of the blood pressure lowering efficacy of ACE inhibitors and angiotensin receptor blockers for primary hypertension
… the magnitude of blood pressure (BP) reduction. ACE inhibitors and angiotensin receptor blockers (ARBs) are two drug classes that, by different mechanisms, inhibit the renin-angiotensin- aldosterone system that regulates BP. As these drugs are widely prescribed for hypertension, it is essential …
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… mechanisms of vasodilation and importance of ACE inhibitor treatment: We identified the importance of the effect of ACE inhibitor treatment on the action of relaxin in human resistance arteries. Relaxin’s vasodilatory action was significantly reduced in those patients on ACE inhibitors (n=28) …
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RADIATION-INDUCED BRAIN INJURY AND THE RENIN-ANGIOTENSIN SYSTEM
… number of activated microglia; an established inhibitor of neurogenesis in the adult rodent hippocampus. The aim of this study was to determine if the angiotensin-converting enzyme (ACE) inhibitor, ramipril, could prevent radiation-induced cognitive impairment. Eighty young adult male, 12-14 …
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Studies on the angiotensin converting enzyme gene polymorphism and Ace inhibitors
Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism …
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¿PLASMA LEVELS OF BRADYKININ AND CLEAVED HIGH MOLECULAR WEIGHT KININOGEN IN PATIENTS WITH IDIOPATHIC ANGIOEDEMA DURING ACUTE ATTACK¿
… and submucosal tissues that can involve lips, face, neck, extremities and/or submucosal tissues of the oral cavity, larynx and intestine. Patients with angioedema can be clinically critical and require urgent clinical evaluation, especially when angioedema affects the larynx (a life-threatening …
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The kidney in diabetes mellitus : urinary transfer in excretion, hypertension, the Renin-Angiotensin-Aldosterone system, and the role of angiotensin converting enzyme inhibitors in therapy
… lisinopril, an angiotensin converting enzyme [ACE] inhibitor, in microalbuminuric and macroalbuminuric diabetic subjects show a reduction in TER independent of reduction in blood pressure. Data are presented suggesting a role for altered renal tubular function in TER in diabetes. The second …
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Acer, a homologue of the human angiotensin-1 converting enzyme, modulates the response of sleep, glycogen storage, lifespan, fecundity and stress resistance to diet in Drosophila melanogaster
Human angiotensin-1–converting-enzyme (ACE) plays a primary role in the regulation of blood pressure and electrolytes as part of the Renin-Angiotensin System (RAS) in humans. Renin cleaves angiotensinogen to angiotensin I and ACE regulates the vasoconstriction of blood vessels by converting …
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Clinical profiles and outcomes of patients receiving acute renal replacement therapy in the cardiac intensive care unit at a South African tertiary centre
… and some of these patients receive Renal Replacement Therapy (RRT). The clinical profiles and outcomes of CICU patients receiving RRT in resource constraint settings like South Africa is unknown. Objectives The objectives of this study were to determine the clinical profiles and outcomes of …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… of captopril, an angiotensin-converting enzyme (ACE) inhibitor which blocks the formation of angiotensin II (ANG II) from ANG I, which relates to the beneficial effects on myocardial hypertrophy and fibrosis (ventricular remodeling) in hypertension. However, ACE has other substrates in addition …
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Adherence to medication in patients with heart failure : effect on mortality and hospitalization
… risk for death and disability. Beta blockers and ACE inhibitors have become standard treatments in heart failure because clinical trials have demonstrated their beneficial effect on mortality and morbidity in these patients. As not much is known about adherence to these medications, the main …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… (ARB) or an angiotensin converting enzyme (ACE) inhibitor (ACEi) can reverse aortic pathology in some mouse models. I set out to better understand the relationship between angiotensin and TAAD in our mouse models, and hypothesized that angiotensin II signaling through the AT1R contributes to …
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Apoptosis in the equine small intestine following experimental ischemia-reperfusion injury
… if use of an angiotensin converting enzyme inhibitor (enalaprilat) would ameliorate the apoptotic response. It was designed to determine if mucosal epithelial cells undergo apoptosis during the ischemia phase and also examined if apoptosis is significantly exacerbated by reperfusion. It also …
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Young-Onset Type 2 Diabetes in the Auckland Region - Clinical Outcomes and Healthcare Service Use in Comparison to Type 1 Diabetes
… 30% with ACR >30mg/mmol were not dispensed an ACE inhibitor/angiotensin receptor blocker. Conclusions: A comprehensive strategy is needed to better manage young-onset T2D addressing socioeconomic disparities.
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… the action of angiotensin-converting enzyme (ACE) on angiotensin I. Angiotensin II, maintains vasomotor tone via its vasoconstrictor action, and also increases salt and water retention by stimulating the release of aldosterone. ACE inhibitors, such as captopril, enalapril and lisinopril, are …
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