Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ACAT2"”.
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The Role of ACAT2 in the Initiation and Treatment of Atherosclerosis
… acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2) synthesizes cholesteryl ester (CE) from free cholesterol and fatty acyl-CoA. ACAT2 is responsible for the packaging of cholesteryl oleate (CO) into VLDL secreted from the liver and studies have shown a relationship between both ACAT2 activity …
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THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
… enzyme acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in cholesterol balance and triglyceride metabolism.
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A COMPARATIVE ANALYSIS OF INTRACELLULAR CHOLESTEROL ESTERIFYING ENZYMES IN MAMMALS
… studies indicate that selective inhibition of ACAT2 prevents progression of atherosclerosis whereas deletion of ACAT1 is deleterious in mice. Due to high sequence similarity, it is difficult to find an isozyme specific inhibitor. Hence, detailed study is required to identify unique structural …
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MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS
… acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and …
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HEPATIC LIPID METABOLISM: THE ROLES OF ACAT2 AND ABCG5/G8 IN THE DEVELOPMENT AND PREVENTION OF DISEASE
… Acyl-CoA:Cholesterol Acyl Transferase isoform 2 (ACAT2) is an enzyme that has been implicated in the development and progression of atherosclerosis and is a target for pharmacological intervention. This dissertation describes a role for ACAT2 and the hepatic ACAT2-derived cholesteryl esters (CE) …