Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"ACAT"”.
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Cholesterinmetabolismus in Toxoplasma gondii : Klonierung und Nachweis der Funktion eines Acyl-CoA: Cholesterin Acyltransferase aehnlichen Enzyms - ein neuer Angriffspunkt fuer pharmakologische Intervention
… hier die Klonierung und Funktion eines ACAT-aehnlichen Enzyms von Toxoplasma gondii (T. gondii), das lebensnotwendig fuer T. gondii zu sein scheint. Medikamente, die gegen die menschliche ACAT gerichtet sind, erhoehen in geringen Konzentrationen die ACAT-Aktivitaet von T. gondii. In …
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A COMPARATIVE ANALYSIS OF INTRACELLULAR CHOLESTEROL ESTERIFYING ENZYMES IN MAMMALS
… of acyl-CoA:cholesterol O-acyltransferase (ACAT) enzymes. Functional studies indicate that selective inhibition of ACAT2 prevents progression of atherosclerosis whereas deletion of ACAT1 is deleterious in mice. Due to high sequence similarity, it is difficult to find an isozyme specific …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… of acyl-CoA: cholesterol acyltransferase (ACAT). Furthermore, in comparison to wild-type MPMs, ACAT-1 deficient MPMs were found to be resistant to apoptosis induced by oxysterols or OxLDL. Macrophages treated with 7KC accumulated ACAT-derived cholesteryl and 7-ketocholesteryl esters. An …
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Zahlen in den Fingern
… im Rahmen der Artifact-Centric Activity Theory (ACAT) untersucht. Dazu werden zunächst die theoretischen Hintergründe zum Zahlensinn, Zahlbegriffserwerb, Teil-Ganze-Verständnis, der Anzahlwahrnehmung und -bestimmung, den Anzahlvergleichen und der Anzahldarstellung mithilfe von Fingern gemäß der …
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Addressing Contaminants in Traditional Foods in Alaska: Environmental Justice Framing and Policy Approaches
… work of the Alaska Community Action on Toxics (ACAT), offers suggestions for strategies that ACAT can use in their activism. These strategies consider how to best use the various EJ frames to effectively communicate with stakeholders (other activist groups and government entities) about the …
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Addressing Contaminants in Traditional Foods in Alaska: Environmental Justice Framing and Policy Approaches
… work of the Alaska Community Action on Toxics (ACAT), offers suggestions for strategies that ACAT can use in their activism. These strategies consider how to best use the various EJ frames to effectively communicate with stakeholders (other activist groups and government entities) about the …
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The Effect of Non-Marine vs. Marine Sources of the Omega-3 Fatty Acids, DHA and EPA, on Serum Lipoproteins
… (ApoB100), acyl-CoA:cholesterol acyltransferase (ACAT), diglyceride acyltransferase (DGAT), low-density lipoprotein receptor (LDLR), and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR). P < 0.05 is considered significant.;Results: The FO diet lowered all fractions of serum lipids and was the …
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Collegiate student-athletes' academic success : academic communication apprehension's impact on prediction models.
… college GPA. The analyses indicated that the ACAT was a valid and reliable measure (alpha = .94) with three factors. In addition, high school core GPA, study hall hour requirement, academic classification, and pre-college standardized test score made significant contributions to the prediction …
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Sterol Binding to Niemann-Pick Type C1 Disease Protein (NPC1) - Implications for its Function in Cholesterol Transport
… of acyl-CoA:cholesterol acyltransferase (ACAT) was not defective in NPC1 mutant fibroblasts. Many studies emphasized the importance of NPC1 in the transport of LDL-derived cholesterol out of the lysosomes. However, there is contradictory evidence for the role of NPC1 in transporting plasma …
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Identification of an Interferon Signaling Pathway Linking Membrane Cholesterol Accessibility to Host Defense Against Pathogens
… of acyl-CoA: cholesterol acyltransferase (ACAT) rapidly mobilized a specific pool of cholesterol termed “accessible cholesterol” from the plasma membrane (PM) to the ER. Importantly, the antibacterial function of 25HC was dependent on this ability to deplete PM accessible cholesterol. …
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Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… of acetyl-coenzyme A acetyltransferase (ACAT), allowing for esterification of cholesterol for storage, and regulation of sterol regulatory element–binding protein (SREBP) localization, a transcription factor that regulates key enzymes for cholesterol synthesis. SREBP cleavage-activating …
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Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis.
<p>Atherosclerosis is a macrophage-dominated nonresolving inflammatory disease of the arterial wall. Macrophage processes, including apoptosis, influence lesion development in atherosclerosis. Cannabinoids, compounds structurally related to Δ<sup>9</sup>-tetrahydrocannabinol (THC), the active …
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Oral Drug Delivery -- Molecular Design and Transport Modeling
One of the major challenges faced by the pharmaceutical industry is to accelerate the product innovation process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A …