Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ABT-737"”.
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The Non-Wnt Functions of APC: Unravelling the Link between APC and Apoptosis
… Taxol® was combined with the Bcl-2 inhibitor, ABT-737. One possible explanation is the increase in Bcl-2 protein upon <i>Apc </i>depletion. However, I found that ABT-737, Taxol® and <i>Apc </i>depletion each cause activation of the unfolded protein response. This suggests that these treatments …
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The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1
… by RNAi or the inactivation of Bcl-xL by ABT-737, a mimetic of the BH3-only protein BAD, was very effective in sensitizing the MPNST cells to apoptotic cell death when combined with the tested anticancer drug Doxorubicin. Because immunohistological staining results showed that both EGFR …
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Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
… in GIST cells with the Bcl-2 inhibitor ABT-737. These studies show that BIM is upregulated in GIST cells and patient tumors after imatinib exposure, and correlates with induction of apoptosis, response by FDG-PET, and disease-free survival. These studies contribute to the mechanistic …
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Taspase1 is a Non-oncogene Mediator of Tumorigenesis and Maintenance
… a targeted inhibitor of BCL-2 family proteins, ABT-737. We found that Taspase1 is over-expressed in multiple primary human tumors, including glioblastoma and melanoma, suggesting that Taspase1 is relevant to tumorigenesis in humans and that its inhibition could be clinically useful. In vitro …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… Bcl-xL, currently employed inhibitors, such as ABT-737 or its clinical counterpart, ABT-263, display limited affinity for Mcl-1. Using nuclear magnetic resonance (NMR) binding assays and computational docking studies, we have recently identified a series of new Apogossypol derivatives, compound …