Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"ABCG2"”.
-
Investigating the function of the multidrug transporter ABCG2
ABCG2 is a polyspecific membrane transporter of the ATP-binding cassette (ABC) superfamily, which is responsible for the efflux of a wide array of structurally unrelated molecules from mammalian cells. Physiologically, the protein is thought to serve a protective role; ABCG2 is expressed in certain …
-
Somatic Stem Cell Populations and Studies on the Functional Role and Regulation of ABCG2
… drugs and other toxins across membranes. Abcg2 is a member of the G family of transporters that was identified in breast cancer cells due to its ability to efflux chemotherapeutic drugs. Abcg2 can also efflux Hoechst 33342, resulting in a side population phenotype when stained cells are …
-
Regulation and functional significance of ATP binding cassette transporters in human placenta
… 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term human placenta, cultured primary trophoblast and BeWo and Jar trophoblast-like cell lines. Jar cells were found to be more similar to nondifferentiated cytotrophoblast with respect to their ABC protein expression …
-
Associations of genetic variants in ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1 with statin-associated muscle symptom (SAMS) in South African populations
… to pharmacogenetic variability of ABCB1, ABCG2, CYP3A4, CYP3A5, and SLCO1B1, particularly in Asian and European populations. However, limited knowledge exists regarding the impact of pharmacogenetics on statin tolerance among South African patients. This study aimed to examine the …
-
Study of porphyrins and heterodimers targeting ABCG2 transporter and development of a multiplexed flow cytometric approach for detection of anti SARS-CoV-2 IgG, IgM and IgA
Resumo: O transportador ABCG2 possui papel central na resistência a múltiplas drogas, porém, nenhum inibidor específico de ABCG2 foi testado em ensaios clínicos. A família de transportadores ABC transporta uma grande variedade de substratos, mas fotossensibilizadores baseados em estruturas …
-
Expression and function of drug transporters in primitive CML cells
… CD34+ cells, CML CD34+ cells over-expressed ABCG2 mRNA. In contrast MDR1 expression was reduced in CML CD34+ cells and MRP1 was detected at similar expression levels in both populations. All three drug transporters were expressed at the protein levels in CML CD34+ cells. It was determined …
-
ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS
… of metabolic enzymes and transporters. The BCRP/ABCG2 efflux transporter was selected for the investigation of the effect of reactive anion, ONOO−, generated during OS and the product of OS, 4HNE, formed after a series of chain reactions involving ROS. Experiments conducted with Sf9 membrane …
-
Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma
… proteins known as ABC transporters (ABCB5 and ABCG2), which mediate cellular resistance by extruding cytotoxic molecules from cells. To palliate these adverse effects, this study primarily aimed to investigate the efficacy of the synergistic actions of chemotherapy (Dacarbazine:DTIC) and …
-
Exploring miR-142-3p in cervical cancer: Implications for treatment response
… the cisplatin-induced upregulation of BCRP/ABCG2 in HeLa cells, suggesting a role in mitigating cisplatin-associated resistance mechanisms. miR-142-3p also reduced cell migration and suppressed EMT features, effects that were amplified in the presence of cisplatin, demonstrated by decreased …
-
NATURAL OR BIO-INSPIRED POLYPHENOLS IN THE SYNTHESIS OF POTENTIAL CHEMOTHERAPEUTIC AGENTS
… DNA, as alpha-glucosidase inhibitors, as ABCG2 inhibitors, as agonist/antagonist of the Bile X receptors, antioxidant and antimicrobial agents. Further goal of this work was an inverse virtual screening focused on magnolol analogues, carried out during my short internship in the lab of …
-
An investigation into the synergistic action of chemotherapy and photodynamic therapy in resistant skin cancers
… cassette (ABC) transporters (ABCB5/1 & ABCG2) expression profile, before and after chemotherapeutic (DTIC) and combination therapy (DTIC+HYP-PDT) treatments.
-
Roles of Nanog, a transcription factor for self-renewal of embryonic stem cells, in prostate tumor initiation and chemoresistance
… The increased expression of ABCB1 and ABCG2 at protein levels in Nanog expressing cells was confirmed by Western blot and immunocytochemistry. Inhibition of ABCB1 activities sensitized Nanog expressing cells toward Taxol and vinblastine, and to less extent, doxorubicin. Blocking of …
-
Mapeamento de QTL para características de produção de leite no cromossomo 6 em rebanhos Gir Leiteiro
… ao marcador BM143 (53 cM), entre os genes ABCG2 e LAPs, estão localizados seis genes incluindo Osteopontina (OPN), PPARGC1A, FAM13A1 e PKD2, onde, diferentes grupos pesquisaram possíveis associações entre genes nesta região e características de produção de leite em bovinos leiteiros, sendo …
-
Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… efflux transporters ABCB1 (P-gp) or ABCG2. No significant correlation was found between CL/F and demographic, body measures and other clinical covariates, and inter-patient variability in CL/F remained similar in magnitude even after correcting dose for body surface area (BSA) or …
-
On the mechanisms of transport and energy coupling in ABC exporters
… LmrA and the human multidrug transporter ABCG2. The dependence of ATP-dependent transport on proton coupling, and the stimulation of MsbA-ATPase by the chemical proton gradient highlight the functional integration of both forms of metabolic energy. It also raises questions about the role …
-
Pharmacogenetics of Tenofovir (Alafenamide or Disoproxil Fumarate Prodrug) Renal Toxicity in HIV positive Black Southern Africans
… genes of interest: ABCB1, ABCC2, ABCC4, ABCC10, ABCG2, AK2, AK3, CES1, CYP3A4, NME1, SLC22A2, SLC22A6, SLC22A8 and SLC22A11. We also explored associations genome-wide. Results: In ADVANCE, 336 participants randomized to either TAF or TDF consented to genetic testing. All were Black-African, 63% …
-
Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… cancer resistance protein (Mdr1a/1b-/-. Abcg2-/-) knockout mice and wild-type mice pre-treated with the P-glycoprotein and breast cancer resistance protein inhibitor, elacridar, have enhanced accumulation of atazanavir in brain and testes tissues compared to control mice. In addition, we …
-
PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… analysis of CSC markers such as CD24, CD133 and ABCG2. PLGA-DS/Cu also inhibited the hypoxiainduced NF-kB expression and blocked the migration and invasion ability of MM cells. It showed substantial toxicity to MM cell lines and reversed hypoxia-induced chemoresistance. Also, PLGA-DS/Cu …
-
Investigation of the effect of disulfiram on the chemoresistance and invasiveness in pancreatic cancer cells
… cells also expressed CSC markers, ‘ALDH, CD133, ABCG2’ and EMT markers, ‘Vimentin, Snail1, N-cadherin, Snail2’. The hypoxia-cultured cells were highly resistant to gemcitabine and paclitaxel. Significantly higher migration and invasion activities were detected in the hypoxia-cultured PDAC cells …
-
Functional interactions of overexpressed transcripts associated to Broad Copy Number Aberrations (BCNAs) in solid cancers [Interazioni funzionali di trascritti over-espressi associati ad ampie aberrazioni del numero di copie nei tumori solidi]
… Synthetase e Biotinidase) e del trasportatore ABCG2, che svolge un ruolo nella resistenza ai farmaci. I risultati hanno indicato che la doxorubicina combinata con i dimeri di ciclodestrina ha una maggiore citotossicità rispetto al farmaco libero, mentre l'incorporazione della biotina nel …
Page 1 of 2