Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ABCC6"”.
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… the ATP binding cassette subfamily C member 6 (ABCC6) gene are the cause of PXE. ABCC6 is primarily expressed by the liver. It has therefore been postulated that PXE is a metabolic disease. While previous studies focused on the effects of individual pathobiochemical processes in different tissue …
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Untersuchungen zur Pathobiochemie der extrazellulären Matrix bei Pseudoxanthoma elasticum (PXE)
… matrix (ECM). PXE is caused by mutations in the ABCC6 gene. By now, no conclusive pathophysiological connection between ABCC6 and the clinical findings of the disease could be established. Particularly, the molecular mechanisms leading to the ECM alterations are unknown. The clinical picture of …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
… genes were upregulated, particularly the ABCC6. Further studies dissected that ABCC6 was involved in site-specific phosphorylation- related chemoresistance. P65/S536D decreased ABCC6 expression and sensitized cells to doxorubicin and RITA, but not paclitaxel that is not the substrate of …
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Novel clinical and etiopathogenetic findings in Pseudoxanthoma elasticum
… over 200 consecutive ischemic stroke patients, ABCC6 hotspot analysis yielded a significant increase in ABCC6 mutations compared to a healthy reference population. This signified another example of heterozygous carriers being prone to cardiovascular and/or cerebrovascular disease and introduced …
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Die Untersuchung zellulärer inflammatorischer Prozesse bei Pseudoxanthoma elasticum
… gene ATP-binding cassette subfamily C member 6 (ABCC6), encoding ABCC6, an ATP-binding transport protein. Further studies indicate an association between PXE and accelerated aging. In vitro an enhanced activity of senescence-associated ß-galactosidase and the formation of a …
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Genes: Multigene Families, Control of Gene Expression, Genetic contributions to Human Diseases, including Chromosomal Fragile Sites and ‘Dynamic’ and ‘Non-self’ Mutations
The early work in this thesis utilizes the general approach of comparative analysis. In order to find out the relationship between entities (either functional or genetic) my colleagues and I have attempted to identify the important elements by detecting similarity between those entities that act in …