Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ABCC2"”.
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
… urine. Organic cation transporter 2 (OCT2) and ABCC2 are highly expressed in the kidney on the basolateral and apical membrane, respectively. We determined the contribution of OCT2 and ABCC2 to cisplatin transport and toxicity. We also evaluated the contribution of genetic variation in both …
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Multidrug resistance-associated protein 2 (MRP2) and oxaliplatin transport
… resistance protein-2 (MRP2), encoded for by the ABCC2 gene, may play a role in determining cellular sensitivity to oxaliplatin by transporting oxaliplatin-derived platinum. Human MRP2-expressing inside-out membrane vesicles prepared from Sf9 insect cells were used for studies of oxaliplatin …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… IL-6-mediated downregulation of Abcb11, Abcc2, Slco2b1 and Slc10a1 was seen in PXR (+/+) but not PXR (-/-) mice, suggesting PXR-dependent regulation. Our IL-6 studies demonstrated that STAT3 inhibition attenuated IL-6-mediated downregulation of almost all transporters. However, …
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Multidrug resistance proteins (MRP) transport the cytokine/nuclear protein High Mobility Group Box 1 (HMGB1) across membranes
… ABC C group. Overexpression of MRP1/ABCC1, MRP2/ABCC2 and MRP3/ABCC3 endows activated cells with the ability to secrete HMGB 1. Moreover, macrophages from Mrp1-1- mice have impaired HMGB1 exocytosis. I also suggest that HMGB1 is unfolded during its translocation. MRP transporters are known to …
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Pharmacogenetics of Tenofovir (Alafenamide or Disoproxil Fumarate Prodrug) Renal Toxicity in HIV positive Black Southern Africans
… 50 kB) in selected genes of interest: ABCB1, ABCC2, ABCC4, ABCC10, ABCG2, AK2, AK3, CES1, CYP3A4, NME1, SLC22A2, SLC22A6, SLC22A8 and SLC22A11. We also explored associations genome-wide. Results: In ADVANCE, 336 participants randomized to either TAF or TDF consented to genetic testing. All …
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Human host and malaria parasite genome variations to susceptibility to malaria
… ABC drug transporters such as ABCC4, ABCC1 and ABCC2 were found to have a higher proportion of pathogenic SNPs in populations of the four malaria endemic areas (> 50%) compared with those from non-endemic areas (< 30%). Principal component analysis (PCA) based on pharmacogenes variants also …
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The genetics of anthracycline-induced cardiotoxicity in cancer patients
… in the following six genes ABCC1 (rs246221); ABCC2 (rs17222723; rs8187710); HNMT (rs17583889); NCF4 (rs1883112): RAC2 (rs13058338) and RARG (rs2229774), and tested for correlation with clinical status and cardiac injury. Finally, a corollary study was conducted on a subset of patients in an …