Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ABCB11"”.
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Genetische Prädisposition der intrahepatischen Schwangerschaftscholestase : Mutationsanalyse des Phospholipidtransporters ABCB4 und der Gallensäurenexportpumpe ABCB11
… play a role in pathogenesis. Mutations in the ABCB11 encoding the bile salt export pump BSEP may as well predispose for ICP. In 28 Swedish and German patients suffering from MSUD a mutational analysis was accomplished, furthermore clinical and biochemical data were obtained and correlations …
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Der kanalikuläre Gallensäurentransporter der Leber als Kandidatengen für den Gallensteinlocus Lith 1
… canalicular bile salt export pump of the liver Abcb11, was characterized in detail and overexpressed in vivo by generating a BAC (bacterial artificial chromosome) transgenic mouse. In a molecular biological analysis, sequence information in unknown regions of the Abcb11 gene was generated and …
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Assoziationen zwischen Polymorphismen lithogener Kandidatengene und Risikofaktoren der Cholesterincholelithiasis
… protein 2 (LRP2) and the bile salt export pump (ABCB11) were tested. Further candidate genes included hepatic lipase (LIPC) in the Lith5 locus and the hepatic HDL receptor (SRB1) known to be associated with serum levels of HDL cholesterol, the major source of biliary cholesterol. In addition, …
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Regulation of Hepatic Drug Transporters Expression in Mice During Acute Inflammation
… PXR. Conversely, IL-6-mediated downregulation of Abcb11, Abcc2, Slco2b1 and Slc10a1 was seen in PXR (+/+) but not PXR (-/-) mice, suggesting PXR-dependent regulation. Our IL-6 studies demonstrated that STAT3 inhibition attenuated IL-6-mediated downregulation of almost all transporters. However, …
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The molecular genetic investigation of paediatric liver disease
… liver failure to be associated with variants in ABCB11 which previously have only been associated with chronic liver disease and liver disease in pregnancy. This thesis has described the identification of the molecular genetic basis of rare causes of paediatric liver disease which has provoked …