Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"ABCA1"”.
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The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes
… cassette transporter, sub-family A, member 1 (ABCA1) mediates the major pathway for cholesterol exit from non-hepatic cells and thereby controls the rate-limiting step in the biogenesis of high density lipoprotein (HDL) particles. In humans,ABCA1 deficiency results in Tangier disease, …
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The Cholesterol Transporter ABCA1 and Cholesterol Accumulation are Key Regulators of Adipose Function in Obesity
… out of ATP Binding Cassette Transporter A1 (ABCA1) to study adipose cholesterol metabolism in mice.
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ROLE OF HEPATIC APOLIPOPROTEIN M AND ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) IN LIPID METABOLISM
Apolipoprotein M (ApoM) and ABCA1 are both expressed in hepatocytes, but their impact on lipid metabolism remains poorly defined. ApoM binds to plasma HDL via its retained signal peptide and transports sphingosine 1–phosphate (S1P). We found that liver–specific apoM transgenic mice had …
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The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
… in-depth computational screen helped us pinpoint ABCA1—a cholesterol efflux protein whose elevated mRNA expression is linked to increased survival. In addition to efflux, ABCA1 can also translocate cholesterol from the inner leaflet of the plasma membrane to the outer layer. Highlighting the …
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THE ROLE OF HEPATOCYTE ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1) AND APOLIPOPROTEIN M (APOM) IN HIGH DENSITY LIPOPROTEIN (HDL) METABOLISM
Hepatic ATP binding cassette transporter A1 (ABCA1) and apolipoprotein M (apoM) both have been shown to influence high density lipoprotein (HDL) metabolism. Hepatic ABCA1, a plasma membrane protein, functions to transport free cholesterol (FC) and phospholipids across the plasma membrane to …
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RARE ABCA1 VARIANTS FOUND ONLY IN AFRICAN AMERICANS AND HOW THEY AFFECT LIPID EFFLUX AND NASCENT HDL FORMATION
… of ATP binding cassette transporter A1 (ABCA1) as the gene responsible for the disease has changed the study of lipoproteins due to almost non-existent levels of HDL-C and increased atherosclerosis in these subjects. The idea that HDL-C and atherosclerosis are inversely correlated …
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tissue-specific role of ATP binding cassette transporter A1 in atherogenesis
ATP binding cassette transporter A1 (ABCA1) facilitates cellular free cholesterol and phospholipid efflux across the plasma membrane to combine with apolipoproteins, forming nascent high density lipoproteins (HDL), the precursor of mature plasma HDL. Mutations in ABCA1 cause Tangier disease, …
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HDL Phospholipid and ABCA1-Mediated Cholesterol Efflux Are Reduced in Patients with Very High HDL-C Who Develop Early Coronary Artery Disease
BACKGROUND: Plasma levels of high-density lipoprotein cholesterol (HDL-C) are strongly inversely associated with coronary artery disease (CAD), and high HDL-C is generally associated with apparent ‘protection’ from CAD. OBJECTIVE: We identified a number of individuals with high HDL-C levels who …
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Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism
… (LDLR) and ATP-binding cassette transporter A1 (ABCA1), a protein that regulates apoE lipidation, have previously been shown to modulate brain amyloid beta levels. In the work presented in this dissertation, we found that increasing LDLR levels enhanced the cellular uptake and degradation of …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… ATP-binding cassette subfamily A member 1 (ABCA1), another risk gene, loads lipids onto apoE, highlighting the importance of lipid homeostasis in AD. MicroRNA-33 regulates the expression of ABCA1 and apoE lipidation, although its effect on amyloid pathology is unknown. Additionally, apoE …
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Lipid acquisition by apolipoprotein A-I in ER and Golgi compartments of primary mouse hepatocytes
… but significant level. In hepatocytes lacking ABCA1, phospholipidation and lipidation by de novo cholesterol were both reduced in Golgi, while ER lipidation remained mostly unchanged. Plasma membrane lipidation by LDL-cholesterol was also significantly reduced. This implies that HDL formation …
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The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… mice and ATP binding cassette transporter A1(ABCA1) and ATP binding cassette transporter G1 (ABCG1) knockout (Abca1-/-Abcg1-/-) mice demonstrated that cellular cholesterol retention leads to Hematopoietic Stem and Progenitor Cell (HSPC) expansion that underlies monocytosis and neutrophilia, …
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Detection of periodontal bacteria in atherosclerotic plaque
… Similarly, the cholesterol transporter gene ABCA1 was highly expressed in P. acnes-infected THP-1 cells in addition to inflammatory cytokines/chemokines TNFα, IL-1β, CCL3 (MIP-1α), cell adhesion molecule ICAM-1. Anti-apoptotic gene BCL2A1 showed the greatest increase in mRNA compared to all …
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Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment
… across membranes. Members of this superfamily, ABCA1 and ABCG1, are key components of the reverse cholesterol transport pathway. ABCG1 acts in concert with ABCA1 to maximize the removal of excess cholesterol from cells by promoting cholesterol efflux onto mature and nascent HDL particles, …
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… via modulation of cell membrane fluidity by ABCA1 inhibition-mediated intracellular cholesterol accumulation in triple-negative IBC cells.</p> <p>In summary, here we provide robust preclinical evidence that supports the Phase I clinical development of combination HDAC and MEK inhibitors, and …
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The Effect Of Proalgazyme And Its Subfractions On Lipid Metabolism In Diet Induced Hypercholesterolemic Hamsters: Correlation With Plasma Metabolomic Profile
… cholesterol transport metabolism, ie, ApoA1, ABCA1, CETP, and SRB1. Lipid profile was correlated with plasma metabolomic profile using 1D 1H NMR spectroscopy and the biologically active fraction has been identified. </p> <p>Further, the study aimed to determine the therapeutic effect of the …
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The Effects of Cholesteryl Ester Transfer Protein Inhibition on High Density Lipoprotein Function
… HDL size (Chapter 3) and increased HDL-mediated ABCA1- and ABCG1-specific cholesterol efflux (Chapter 4). Treatment with 10 mg/day AMG-899 also improved the anti-inflammatory properties of HDLs (Chapter 5), while HDLs isolated from subjects after treatment with 2.5 mg/day and 10 mg/day AMG-899 …
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Investigating the physiological function of Alzheimer’s disease risk gene Abca7 in the central nervous system
… As the closest homologous protein of Abca7 is Abca1, a key cholesterol and lipid transporter in the body, I also investigated the potential role of Abca7 in neuro-lipid processing in Chapter 4. I did not identify differentially expressed lipid species in the presence versus absence of Abca7 in …
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Einfluss einer ABCC6-Defizienz auf die Remodellierung der extrazellulären Matrix in in vitro und ex vivo Gewebemodellen
… lower expression of the cholesterol transporter ABCA1 in the adipocytes. Increased levels of cholesterol in gallbladders and of cholic acid in serum indicated a shifted metabolite profile in bile acid metabolism and disruption of enterohepatic circulation in the Abcc6-/- mouse model.<br /> …
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