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Showing 1 to 20 of 72 for “"ABC transporters"”.
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Mechanistic studies of ABC transporters
ATP-binding cassette (ABC) transporters are a superfamily of primary membrane transporters that are abundant yet highly diverse in structures and functions. These proteins power the active transport of a large variety of substrates across biological membranes, by harnessing the energy of ATP …
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The regulation of yeast homotypic membrane fusion by class C ABC transporters
… system that regulates cellular traffic. The ABC transporter superfamily is present in all organisms and is responsible for actively transporting a wide range of substrates across the lipid bilayer. Several class C ABC transporters interact with factors that are important in the fusion …
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Structural Study of Disease Relevant ABC Transporters-Cystic Fibrosis Transmembrane Conductance Regulator and ABCA4
<p>ATP-binding cassette (ABC) transporters are primary transporters that utilize the energy from ATP binding and hydrolysis to transport substrates across membrane against their concentration gradients. Structurally, canonical ABC transporters consist of four subunits— two transmembrane domains …
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Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria
Multidrug transporters in the ATP-Binding Cassette (ABC) superfamily play critical roles in pathogenic bacteria. These transport systems are particularly important in conferring antibiotic resistance on the cell by mediating the efflux of a wide range of structurally unrelated compounds and the …
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Functional Expression of ABC Transporters at Blood-tissue Barriers: Relevance to Antiretroviral Drug Tissue Distribution
… repopulation. ATP-binding cassette drug efflux transporters i.e., P-glycoprotein and breast cancer resistance protein, have been previously shown to efflux antiretroviral drugs at the level of blood-brain barrier (Dallas, et al., 2004a;Lee, et al., 2007;Lee and Bendayan, 2004;Ronaldson, et al., …
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Identifizierung und Charakterisierung des vakuolaren ABC-Transporters Mlt1p und der Phospholipase B Plb5p von Candida albicans
… und Charakterisierung des ATP-Binding-Cassette-(ABC)-Transporter-Gens caMLT1 aus C. albicans. CaMlt1p zählt zur MRP/CFTR-Unterfamilie ATP-bindender Transportproteine, eine Proteinkategorie, die in diesem Pilz bislang noch nicht beschrieben wurde. Energiebetriebene Transportproteine der …
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Characterization of Cre Mouse Models to Target CNS Barriers for Generating Conditional Knockouts of ABC Transporters
… water composition). These barriers also express ABC transporters, including P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP), which are known to contribute to efflux of endogenous toxins and therapeutics from the CNS. Pgp and BCRP expression and activity are a crucial determinant …
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Expression des ABC-Transporters ABCA3 in Zellen der physiologischen Hämatopoese und in maligne transformierten lymphatischen Zellen
… Efflux von Chemotherapeutika aus der Zelle durch ABC (ATP-binding-cassette)-Transporter vermittelt. Der ABC-Transporter ABCA3 konnte in Vorarbeiten in der Mehrzahl von AML-Blasten nachgewiesen werden. Eine hohe ABCA3-Expression korrellierte hier mit einem schlechteren Ansprechen auf Chemotherapie …
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ABCB6 Is a Porphyrin Transporter with a Novel Trafficking Signal That Is Conserved in Other ABC Transporters
<p>The ATP-binding cassette (ABC) transporters play an important role as a barrier to protect cells from the accumulation of toxic xenobiotics and metabolites due to their ability to translocate a wide array of compounds across lipid bilayers. However, many ABC transporters, especially the ones …
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Investigations into the Lipid Transport Mechanisms and Energetics of Bacterial ATP-Binding Cassette (ABC) Transporters MsbA and LmrA
… in research on multidrug ATP-binding cassette (ABC) transporters. The bacterial transmembrane protein LmrA from *Lactococcus lactis* was the first known prokaryotic ABC transporter homologue of the mammalian multidrug resistance transporter ABCB1 (P-glycoprotein) characterised to have multidrug …
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THE ARABIDOPSIS THALIANA ABC TRANSPORTERS TAP1, NAP8 AND ATH12 EXTRUDE PEPTIDES FROM CHLOROPLASTS AND ARE LINKED TO CHLOROPLAST PROTEIN HOMEOSTASIS MAINTENANCE.
… proteine danneggiate, da parte del trasportatore ABC HAF-1 localizzato sulla membrana interna del mitocondrio. HAF-1 è omologo al trasportatore di peptidi mitocondriale MDL1 di lievito, che se rimosso causa sensibilità al calore. In questo lavoro, i trasportatori ABC del cloroplasto di …
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Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment
… mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a group of evolutionarily highly conserved cellular transmembrane proteins that mediate the ATP-dependent translocation of substrates across membranes. Members of this …
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Structure and Mechanism of PCAT1, a Polypeptide Processing and Secretion Transporter
<p>ATP-binding cassette (ABC) transporters utilize the energy from ATP to transport substrates across biological membranes. Various ABC transporters perform diverse biological functions across all forms of life ranging from importing essential nutrients to exporting toxic drugs (Ford and Beis 2019; …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… adenosine triphosphate (ATP)-binding cassette (ABC) transporters P-glycoprotein (Pgp) and multidrug resistance associated protein 1 (MRP1), which efflux many drugs used in neuroblastoma therapy, has been implicated in poor outcome in neuroblastoma. Therefore, the purpose of our studies was to …
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Characterizing the role of ATP-binding cassette transporters in triterpenoid wax bloom production
… fully elucidated. Numerous ATP-binding cassette (ABC) transporters have been characterized in model systems and crops, and some members of the G transporter subfamily are linked to the production of epicuticular wax blooms. Many studies utilizing model systems focus on long-chain aliphatic wax …
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Štúdium modulácie cytostatickej rezistencie pomocou vybraných cielených protinádorových liečiv
… is the overexpression of ATP-binding cassette (ABC) transporters. These are a group of transmembrane proteins that negatively impact the efficacy of chemotherapy by reducing the intracellular concentration of drugs through their efflux out of the cells. Inhibition of these transporters appears …
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Age-Associated Hepatic Drug Transporter Expression and Its Implications for Pediatric Pharmacotherapyflexibility affect DNA topoisomerase I function
<p>Members of the ATP-binding cassette (ABC) family of drug transporter proteins translocate various endogenous and exogenous substrates across intra- and extracellular membranes. Two specific ABC transporters, the multidrug resistance 1/P-glycoprotein (MDR1/P-gp) and the multidrug resistance …
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Comparison of the therapeutic efficacy of SNAP-tag fusion protein and the synergistic actions of chemotherapy and photodynamic therapy in killing resistant melanoma
… expression of membrane proteins known as ABC transporters (ABCB5 and ABCG2), which mediate cellular resistance by extruding cytotoxic molecules from cells. To palliate these adverse effects, this study primarily aimed to investigate the efficacy of the synergistic actions of chemotherapy …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… chemistries. The ATP-binding cassette (ABC) transporters are efflux proteins that assist in maintaining the BBB interface and serve as a first line of defense to mosquitocide exposures. To date, there are three subfamilies (ABC -B, -C, -G) of ABC transporters; however, knowledge of these …
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Functional characterization and expression of molluscan detoxification enzymes and transporters involved in dietary allelochemical resistance
… (CYP), glutathione S-transferases (GST) and ABC transporters in the generalist marine gastropod Cyphoma gibbosum feeding on a variety of chemically defended gorgonian corals, and to identify those dietary natural products that act as substrates for these proteins. Molecular and proteomic …
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