Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"ABC transporter"”.
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On the mechanisms of substrate translocation by the ABC transporter MsbA
… pumps in cells. MsbA is an ATP-binding cassette (ABC) protein in Gram-negative bacteria that can mediate the efflux of a wider range of antibiotics but also mediates the flopping of phospholipids and Lipid-A core across the plasma membrane. The MsbA protein has a similar fold as the mammalian …
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Effect of oral hypoglycaemic agents on placental ABC transporter expression and activity
… a network of apical ATP-binding cassette (ABC) transporters facilitates the efflux of substances away from the fetus, thereby protecting the fetus from exposure to unwanted substances including medications such as metformin and glibenclamide. In this thesis, I have examined the mRNA levels …
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Identification and molecular characterization of a putative heme ABC transporter in Neisseria meningitidis
… in the periplasmic space, a heme dedicated ABC transporter has been hypothesized to convey heme into the cytoplasm. To address this hypothesis, we used several molecular techniques to identify and characterize a putative heme ABC transporter in Neisseria meningitidis. Using 2-D gel …
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Identification and characterization of an adenosine triphosphate binding cassette (ABC) transporter EcABCB1 involved in the transport of alkaloids in Eschscholzia californica
… called adenosine triphosphate binding cassette (ABC) transporters have been implicated in the influx of alkaloids in plants. We report the isolation and characterization of a full-length cDNA encoding a homologous ABC transporter EcABCB1 from California poppy. The gene encoding EcABCB1 …
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Mutants of Drosophila Melanogaster's ABC Transporter, White, Have Altered Cholesterol-Mediated Acquisition of Memory that is Moderated with 5-HT
… encodes an ATP binding cassette G-subfamily (ABCG) half transporter for the precursors of eye pigments and possibly biogenic amines, 5-hydroxytryptamine (5-HT) and dopamine that are critical for olfactory learning and memory in Drosophila. ABCG transporters are also known for their roles in …
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Expressionsprofile von ABC-Transportern in Arabidopsis thaliana
Die Superfamilie der ABC-Proteine ist eine der größten bisher bekannten Proteinfamilien. Ihre Mitglieder enthalten ein oder zwei nukleotidbindende Domänen mit je einem Walker A- und B-Motiv, sowie das charakteristische ABC-Motiv. Ein Großteil darunter sind Membranproteine, die zusätzlich ein oder …
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Toxicological Analysis of Tacrines and Verapamil on the Yellow Fever Mosquito, Aedes aegypti
… chemistries. The ATP-binding cassette (ABC) transporters are efflux proteins that assist in maintaining the BBB interface and serve as a first line of defense to mosquitocide exposures. To date, there are three subfamilies (ABC -B, -C, -G) of ABC transporters; however, knowledge of these …
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Characterizing the Interaction of the ATP Binding Cassette Transporters (G subfamily) with the Intracellular Protein Lipid Environment
… mediated by members of the ATP binding cassette (ABC) transporter superfamily. ATP-binding cassette (ABC) transporters represent a group of evolutionarily highly conserved cellular transmembrane proteins that mediate the ATP-dependent translocation of substrates across membranes. Members of this …
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Identification of up-regulated genes of the hyphomycete, Beauveria bassiana, during infection of Leptinotarsa decemlineata
… peptidase, a/b-hydrolase enzyme), three probable transporters (ABC transporter, siderophore transporter, oligopeptide transporter), a presumed metabolic enzyme (pyruvate decarboxylase), a probable V-ATPase, two putative mucin-like proteins and a putative protein, which shares homology with an …
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Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria
Multidrug transporters in the ATP-Binding Cassette (ABC) superfamily play critical roles in pathogenic bacteria. These transport systems are particularly important in conferring antibiotic resistance on the cell by mediating the efflux of a wide range of structurally unrelated compounds and the …
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Characterization of the Reaction Cycle of MJ0796: A Model Archaeal Adenosine Triphosphate-Binding Cassette Transporter Nucleotide Binding Domain
Adenosine-triphosphate binding cassette (ABC) transporters couple nucleotide hydrolysis to vectorial transport of solutes across lipid bilayers. These proteins, found in all kingdoms of life, have been implicated in a variety of human genetic disorders and engender drug resistance in cancer cells …
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Cytometry of Reaction Rate Constant (Crrc): Optimization of the Technique and Development of a Novel Protocol to Assess Cell Population Heterogeneity Based on Aldh1a1 Activity in Vitro
… in vitro by investigating the activity of ABC-transporter enzymes. However, CRRC showed poor robustness to highly motile cells. Here, I report on the development of a workflow to make CRRC robust to cell motility. The novel workflow was used to develop a protocol for in vitro CRRC studies …
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The development of a new reporter system to study the interaction between FbpA and FbpBC
… binding protein (FbpA). FbpA is part of the ABC transporter, FbpABC that transports iron from the periplasm into the cytoplasm. The interaction between FbpA and FbpBC is currently unknown. A series of site directed mutants were created to study this interaction based on models of other ABC …
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The influence of genetic background on drug resistance in the malaria parasite Plasmodium falciparum
… important for clinical resistance in the future. Transporter proteins have key roles in drug resistance across a variety of organisms — in *P. falciparum*, the spread of resistance to the antimalarial chloroquine in the 1950s and 60s is largely due to mutations in the Chloroquine Resistance …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… adenosine triphosphate (ATP)-binding cassette (ABC) transporters P-glycoprotein (Pgp) and multidrug resistance associated protein 1 (MRP1), which efflux many drugs used in neuroblastoma therapy, has been implicated in poor outcome in neuroblastoma. Therefore, the purpose of our studies was to …
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Untersuchungen zum Fettsäuretransport durch zelluläre und peroxisomale Membranen
… In Hefen und Pflanzen wurden peroxisomale ABC-Transporter identifiziert, die eine essentielle Funktion bei der Aufnahme von Fettsäuren im Zuge der β-Oxidation haben. Trotz vergleichbarer Komponenten scheint sich der Mechanismus des Fettsäure-Imports in Peroxisomen der Pflanzen grundlegend …
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Nuclear receptor co-repressor actions in bladder cancer
… with a xenobiotic protective response (ABC transporter proteins, metabolizing enzymes and cell cycle arrest proteins) as assessed by microfluidic quantitative real-time reverse transcription polymerase chain reaction. NCoR1 over-expression was targeted with co-treatment with NR ligand …
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In vitro Zellkulturmodelle der Blut-Hirn-Schranke zur Untersuchung der Permeation und P-Glycoprotein-Interaktion von Arzneistoffen
… Charakter der Zellen. Immunfärbungen des ABC-Transporters Mrp2 waren negativ. Die Ex-pression von P-Glycoprotein konnte dagegen nachgewiesen werden. Die Charakterisierung des in vitro Permeationsmodells der Blut-Hirn-Schranke erfolgte an-hand von Permeationsversuchen. Aufgrund der …
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Isolierte Gehirn-Kapillaren als in vitro-Modell der Blut-Hirn Schranke
… anhand dessen man insbesondere den Einfluß der ABC-Transporter-Proteine P-Glykoprotein und Mrp2 auf den Transport von Arzneistoffen an der Blut-Hirn Schranke untersuchen kann. Es wurde untersucht, ob frisch isolierte Kapillaren aus dem Gehirn von Schweinen für diese Fragestellung geeignet sind, …
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The Molecular Mechanism of the Escherichia Coli vitamin B12 Transporter BtuCD-F: Real-time Observation of the Transporter in Motion
The Escherichia coli vitamin B12 transporter BtuCD-F is a type II importer belonging to the ABC transporter superfamily. Available data suggest both exporters and type I importers in the ABC superfamily employ similar transport mechanism in which the transmembrane (TMDs) are open to cytoplasm in …
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