Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"AAA proteins"”.
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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
… I explore how mutations in active sites of proteins can be leveraged to understand inhibitor binding and to design selective chemical inhibitors. In my thesis work I focus on the design of chemical probes for proteins from the AAA (ATPase Associated with diverse cellular Activities) …
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Using Small Molecule Tools to Study ATPase Mechanoenzymes
<p>The dysregulation of AAA (ATPases associated with diverse cellular activities) mechanoenzymes has been linked to diseases, and chemical inhibitors and activators can be powerful tools to probe mechanisms and test therapeutic hypotheses. However,the structural conservation across the AAA protein …
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Chemical Biology of Dynein
<p>Cytoplasmic dynein is a AAA (ATPase Associated with various Activities) motor protein that transports cellular cargoes towards the microtubule minus-end. Despite its essential role in intracellular transport, dynein remains the least understood cytoskeletal motor. With speeds >25 μm/min in …
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Role of the MecA adaptor protein in regulation of the AAA + chaperone ClpC of Bacillus subtilis
ClpC, a member of the AAA+ protein superfamily from Bacillus subtilis, is forming with ClpP a proteolytic system, that is part of the protein quality control system and involved in general proteolysis of misfolded and aggregated proteins. In addition ClpCP together with the adaptor MecA is …
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Communication & coordination between components of the ClpAP degradation machine
AAA+ (ATPases associated with diverse cellular activities) proteases are present in all kingdoms of life. These molecular machines perform energy-dependent regulated proteolysis. The bacterial enzyme ClpA is a double-ring hexameric AAA+ unfoldase/translocase that functions with the tetradecameric …