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Showing 1 to 20 of 70 for “"A549 cells"”.

  1. Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells

    Kemp, CalvinDepartment of Molecular and Cell Biology2025

    … cytokine genes in the lung epithelium fibroblast A549 cell line. Evidence suggests that the EGF-induced repression acts on signalling via the TLR-2 receptor but not via the protein kinase C (PKC) pathway. The EGF response is shown to act via the nuclear factor kappa B (NF-κB) promoter element in a …

    cape-town Repository record

  2. The effect of quinoline anti-malarial drugs on the endolysosomal and secretory pathways of plasmodium falciparum strain 3D7, dictyostelium discoideum and mammalian A549 cells

    Roberts, LindiDivision of Clinical Pharmacology2007

    … secretion in malarial parasites and mammalian cells. In this study, the effects of chloroquine, amadiaquine, halofantrine, mefloquine and quinine on the endolysosomal systems in Plasmodium falciparum 3D7, Dictyostelium discoideum and A549 pulmonary cancer cells were examined.

    cape-town Repository record

  3. Cell-Specific Inhibition of Interferon Production by Rotavirus

    Shahrudin, ShabihahResearchSpace@Auckland2019

    … the intestinal (Caco-2) and the alveolar basal (A549) epithelial cells. Our findings confirmed the potential ability of the virus to establish extra-intestinal infection in A549 cells. Furthermore, our results showed up-regulated IFNs and ISGs transcription in RV-infected A549 cells, which was …

    auckland-ms Repository record

  4. Characterization of the antiviral activity of cyclosporine A against dengue virus

    Sangwan, Ujjwal2024

    … activity and mechanism of CsA against DENV-2 in A549 lung alveolar epithelial cells, Huh7 human hepatoma cells, and THP-1 monocyte-derived macrophages. We demonstrated that CsA effectively inhibits DENV-2 in all three cell types. Notably, the antiviral activity of CsA against DENV-2 is …

    queens Repository record

  5. Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration

    Liu, JunCreighton University2013

    … EMT in non-malignant murine biliary epithelial cells (cholangiocytes, 603B cells) and human lung epithelial carcinoma cells (A495 cells). We examined collagen production and cell survival in 603B cells and cell migration in A549 cells during TGF-β1-induced EMT. The involvement of Snail1 in …

    creighton Repository record

  6. The effects of the Parkinson’s disease-associated proteins LRRK2 and TMEM175 on the lysosomal profile of cultured mammalian cells under lysosomal stress conditions

    Himanka, EllaHelsingin yliopisto2025

    … in lysosomal characteristics in mammalian A549 cells with distinct LRRK2 genotypes, and in human and mouse microglial lines under basal conditions and lysosomal stress. The pathogenic PD-associated LRRK2 mutations have been shown to increase LRRK2 kinase activity, causing increased …

    helsinki Repository record

  7. Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549

    김, 설화2011

    … stimulation via CysLTR1 in human lung epithelial A549 cells. METHOD: To investigate the effect of LTD4 and CysLTR1 on MCP-1 and IP-10, Two different kinds of epithelial cells, A549 cells and CysLTR1 over-expressed A549 cells, were prepared and treated with LTD4 100nM for 0.5, 1, 2, 4 and 8hours. …

    ajou Repository record

  8. Nrf2-Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer, Especially Squamous Cell Carcinoma

    김, 영선2011

    … RESULTS 12 A. Localization of Prx III and Srx in A549 cells 12 B. Oxidation of Prx III in mink lung epithelial cells 12 C. Srx dependent regulation of Prx III oxidation in A549 cells 15 D. Srx is translocated into the mitochondria under oxidative stress 15 E. Overexpression of Prx I and III …

    ajou Repository record

  9. Investigation of the interactions between selected nanoparticles and human lung carcinoma cells at the single cell and single particle level

    Stayton, IsaacMissouri University of Science and Technology2016

    … nanoparticles and living human lung carcinoma (A549) cells"--Abstract, page iv.

    must-thes Repository record

  10. The Effects of Tarsh Overexpression on Lung Carcinomas

    Kim, Young2018

    Lung cancer arises from epithelial cells that line the air passages of the lungs. It is the second most common malignancy in the United States; trends suggest that over 228,000 new patients will be diagnosed with lung cancer in 2013. Due to the fact that lung cancer is highly aggressive, it has …

    vcu Repository record

  11. Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target

    반, 가영2016

    … in the sputum granulocytes, peripheral blood cells (PBCs), and peripheral blood eosinophils (PBEs) between patients with severe asthma and those with non-severe asthma and investigated the functional effects of autophagy. Methods: We enrolled 36 patients with severe asthma, 14 with non-severe …

    ajou Repository record

  12. TDI 천식 기도염증반응과 관련된 활성산소의 역할

    김, 성호2011

    … 13 8. Statistical analysis 14 C. Method 14 1. Cells culture and treatment with TDI 14 2. Real-time reverse transcriptase polymerase chain reaction 15 3. Preparation of FITC-DBP conjugate and immunofluorescence staining 16 4.Flow cytometry analysis 16 5. Western blot analysis 17 6. Measurement …

    ajou Repository record

  13. Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4

    오, 정미2011

    … was investigated using lung carcinoma cell line, A549 cells, by real time PCR and flowcytometry. Effect of MK-571 on the transcriptional induction of CysLTR1 by IL-4 was examined by luciferase reporter assay. Results: In the screening of 5？ upstream region of CysLTR1 gene in 43 normal healthy …

    ajou Repository record

  14. Identification of the Pla2 Responsible For Prostanoid Synthesis in Response to Inflammatory Cytokines

    Fernando, Chaminda2014

    … closely-related isoforms of phospholipase A2 in A549 cells and used an enzyme linked immuno sorbent assay (ELISA) to quantitate the PGE2 produced. These studies found that cytosolic phospholipase A2α (cPLA2α) regulated 97.7% of the prostaglandin E2 (PGE2) produced in response to inflammatory …

    vcu Repository record

  15. The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells

    Greig, JustinUniversity of Strathclyde2019

    … S1P plays in EMT, proliferation and migration in A549 lung epithelial carcinoma and PANC-1 pancreatic epithelial carcinoma cell lines. Changes in the expression of E-cadherin (an epithelial cell marker) and vimentin (amesenchymal cell marker) were difficult to detect, which compromised the aim to …

    strathclyde Repository record

  16. Toxicological and Pharmacological Studies on Amide Derivatives of 5-Methoxymethyl-2'-Deoxycytidine

    Mannala, ShajanUniversity of Saskatchewan1999

    … would act selectively on virus infected cells. The antiviral activity of amide derivatives of 5-Methoxymethy1-2i-deoxycytidine (MMdCyd), namely, acetyl-MMdCyd, propanoyl-MMdCyd, butanoyl-MMdCyd and hexanoyl-MMdCyd against Herpes simplex virus type 1 (HSV-l), in A 549 cells and VERO cells …

    sask Repository record

  17. IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner

    Price, Deanna2021

    … that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the mechanism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung cancer cells. A …

    emich Repository record

  18. Design, Off-Target Toxicity, and Intracellular Processing of Nucleotide-Modified Messenger RNAs for Human Therapies

    Mulroney, ThomasUniversity of Cambridge2020

    … mRNA (IVT mRNA) is introduced to cells for therapeutic applications. IVT mRNA is transfected into target cells, translated, and the fully-synthesised encoded protein exerts a therapeutic effect via specific mechanisms. IVT mRNAs have been applied to treatment of inherited protein …

    cambridge Repository record

  19. Analysis of the interactions between Aspergillus fumigatus, Pseudomonas aeruginosa and a model of the alveolar surface

    Margalit, AnatteNational University of Ireland Maynooth2019

    … induction of a hypersensitivity response in host cells. The interactions between A. fumigatus and host epithelial cells, such as the alveolar epithelial cell line A549, have been well characterized. The response of A549 cells to exposure by multiple pathogens is less well understood. With this in …

    maynooth Repository record

  20. Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells

    Molloy, Emer LouiseNational University of Ireland Maynooth2008

    … for BMP signalling in adult airway epithelial cells (AECs) and to further investigate BMP signalling during airway inflammation. AECs used included the transformed bronchial cell line, BEAS-2B, the adenocarcinoma-derived cell line, A549, and normal primary murine airway epithelial cells …

    maynooth Repository record

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