Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 170 for “"A549"”.
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… cytokine genes in the lung epithelium fibroblast A549 cell line. Evidence suggests that the EGF-induced repression acts on signalling via the TLR-2 receptor but not via the protein kinase C (PKC) pathway. The EGF response is shown to act via the nuclear factor kappa B (NF-κB) promoter element in a …
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The anticancer effects of the different analogs of cysteine deleted tachyplesin on A549 lung cancer cells
… and Serine-Control CDT. MTT assays against the A549 adenocarcinoma lung cancer cell line showed All D-CDT to be the most effective analog in preventing cancer cell growth. Hyaluronidase and apoptosis assays were performed to better understand the mechanism by which the All D-CDT is preventing …
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
… stimulation via CysLTR1 in human lung epithelial A549 cells. METHOD: To investigate the effect of LTD4 and CysLTR1 on MCP-1 and IP-10, Two different kinds of epithelial cells, A549 cells and CysLTR1 over-expressed A549 cells, were prepared and treated with LTD4 100nM for 0.5, 1, 2, 4 and 8hours. …
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IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
… that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the mechanism employed, we used CD44-negative normal human lung cells (HFL1), A549, and H1299 (p53-null) lung cancer cells. A …
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The effect of quinoline anti-malarial drugs on the endolysosomal and secretory pathways of plasmodium falciparum strain 3D7, dictyostelium discoideum and mammalian A549 cells
… falciparum 3D7, Dictyostelium discoideum and A549 pulmonary cancer cells were examined.
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Cell-Specific Inhibition of Interferon Production by Rotavirus
… the intestinal (Caco-2) and the alveolar basal (A549) epithelial cells. Our findings confirmed the potential ability of the virus to establish extra-intestinal infection in A549 cells. Furthermore, our results showed up-regulated IFNs and ISGs transcription in RV-infected A549 cells, which was …
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Characterization of the antiviral activity of cyclosporine A against dengue virus
… activity and mechanism of CsA against DENV-2 in A549 lung alveolar epithelial cells, Huh7 human hepatoma cells, and THP-1 monocyte-derived macrophages. We demonstrated that CsA effectively inhibits DENV-2 in all three cell types. Notably, the antiviral activity of CsA against DENV-2 is …
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NLRP2 expressziójának vizsgálata különböző immortalizált sejtvonalakon
… A kísérletek során THP-1, K562, Caco2, A549, NB4, U937, Hela és MCF-7 sejtvonalakat használtunk, melyeket 6, valamint 24 órás GM-CSF és dexametazon kezeléseknek vetettük alá. A kezelt sejtekből RNS-t izoláltunk, majd RT-qPCR segítségével meghatároztuk az NLRP2 relatív expresszióját. Az …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… survival in 603B cells and cell migration in A549 cells during TGF-β1-induced EMT. The involvement of Snail1 in mediating these disease-associated alterations was further evaluated to investigate the potential direct links between EMT and liver fibrosis as well as cancer metastasis. We showed …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… pulmonary artery smooth muscle cells (PASMC) and A549 adenocarcinoma cells with either Compound 6 or Drpitor1a inhibited mitochondrial fission as determined using an imaging-based machine learning algorithm. xCELLigence and EdU assays showed inhibition of cell proliferation in both PAH PASMC and …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
… study it was determined that NSCLC cell lines (A549, A427, SK-LU-1) expressed the type I IGF-I receptor protein and IGF-I stimulated the proliferation of low density plated (2000 cells/cm² growth area) carcinoma cells by 1.6- to 3- fold above control after a four day inCUbation period under …
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The significance of the EGFR pathway in malignant pleural mesothelioma
… NCI-H2052, NCI-H2452 (mesothelioma) and A549 (lung cancer) were utilised. All cell lines were tested for EGFR, KRAS and BRAF mutations. Cells were incubated with Cetuximab, Gefitinib, Rapamycin, Ku0063794 (MTOR kinase inhibitor) and Celecoxib as single agents and in combinations and …
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The Effects of Tarsh Overexpression on Lung Carcinomas
… p53 expression in two lung cancer cell lines: A549 and H1299 cell lines. It was determined that increasing the expression of Tarsh decreased the rate of proliferation in both cell lines. Additionally, it was shown that the knockdown of p53 increased proliferation in A549 cells. In regards to …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… S1P plays in EMT, proliferation and migration in A549 lung epithelial carcinoma and PANC-1 pancreatic epithelial carcinoma cell lines. Changes in the expression of E-cadherin (an epithelial cell marker) and vimentin (amesenchymal cell marker) were difficult to detect, which compromised the aim to …
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Efficacy of a Magnetic Drug Delivery System and Development of an Orthotopic Lung Tumor Imaging Model
… 2) Doxorubicin containing NIMs are more toxic to A549 lung adenocarcinoma cells as free drug, making NIMs ideal for a targetable inhaled drug delivery vehicle. Concomitantly, we developed a lung cancer animal-imaging model by subcutaneous xenograft and orthotopic lung implantation of NSCLC …
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Modulation of the Expression of Multidrug Resistance Proteins by Sulforaphane and Erucin
… transcription. Non-small cell lung cancer cells (A549) and human liver carcinoma cells (HepG2) were transfected with an MRP1-luciferase reporter gene and treated with SF or ER. Neither SF nor ER increased luciferase activity in the transfected cells. In addition, overexpression of Nrf2 in A549 …
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Molecular pathways controlling DNA damage response
… treated lung and mesothelioma cancer cell lines (A549, Mero-14, and Mero-25). Our results suggest there is no impact of Etoposide treatment on the TTC5 protein levels in all treated cell lines. Upregulation of p53, K382 and S46 protein expression levels as a response to the DNA damage in A549 and …
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Docetaxel uptake and modulation of P-gpmediated docetaxel efflux by tyrosine kinase inhibitors in human lung carcinoma cell lines
… to examining docetaxel uptake in the DLKP and A549 NSCLC cell lines and docetaxel accumulation and efflux in the Pgp over-expressing A549-Taxol and DLKP-A cell lines. Passive diffusion is believed to be the mechanism of uptake for docetaxel in most cancer cells due to its lipophilic …
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Essentiality of Mitochondrial Genome Integrity in Cell Survival
… apoptosis. In addition, EXOG downregulation in A549 control and A549 rho0 cells, which are depleted of mitochondrial DNA, induced cell death in A549 control but not in A549 rho0 cells, suggesting that damage and downstream breakage of mitochondrial DNA are necessary for activating cell death. …
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Bone Morphogenetic Protein Signalling in Adult Lung Epithelial Cells
… BEAS-2B, the adenocarcinoma-derived cell line, A549, and normal primary murine airway epithelial cells (MAECs). BMP2 and BMP4 inhibited E-cadherin expression in BEAS-2B cells. In addition, BMP4 induced an epithelial-mesenchymal transition (EMT) in BEAS-2B where cells acquired a mesenchymal …
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