Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"A2BR"”.
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… coupled adenosine receptors: A1R, A2AR, A2BR, and A3R. However, the relationship between these factors is poorly understood. Recent findings suggest the A2BR has been implicated in the regulation of both chronic lung disease and acute lung injury. The work presented in this dissertation …
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Purinergic Signaling Regulates Filopodia-Induced Zippering
… its activation of the adenosine receptor A2B (A2BR) induces cell-cell adhesion to promote barrier function. This barrier function is known to be important in maintaining homeostasis during hypoxia, trauma, and sepsis. Loss of this epithelial barrier function provides a considerable advantage …
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Design and synthesis of new potential anticancer agents and high-selective A2B antagonists
… to evaluate the affinity and selectivity toward A2BR subtype, further confirming the high potential of these compounds as A2B antagonists.
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Investigating the molecular pharmacology of class A and B G protein-coupled receptors
… to include other Adenosine receptors: the A1R, A2BR and A3R, as well as the β2 adrenoceptor, to allow for comparison between different class A GPCRs. Work pertaining to the CLR begins with an investigation into interactions between a subset of class B GPCRs and RAMPs at the cell surface, with …
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Adenosine A2b Receptor Effects On Post-Mi Remodeling And Cardiac Fibroblast Function
… infarct size did not differ between genotypes. A2BR expression was 2.7 fold greater in WT scar zone compared to remote zone. TNF-α and MMP-9 expressions in the scar zone and collagen 1 and 3 mRNA levels in the remote zone were much greater in 5-day WT group without any change in macrophage …
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Modulation of cyclic adenosine monophosphate (cAMP) signalling and its therapeutic potential: pharmacological characterisation of PDE inhibitors
… (ARs), and compound 4 was more potent when A2BR was expressed. Compound 2 seems to possess toxic effects that may be independent of action to A2AR or PDE10A. Lastly, preliminary studies were conducted to investigate the possibility of biased signalling by RAMPs on protease-activated receptor …
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The Role of Il-6 In Adenosine-Mediated Pulmonary Fibrosis
<p> <p>Adenosine is a purinergic signaling molecule that regulates various aspects of inflammation and has been implicated in the pathogenesis of chronic lung diseases. Previous studies have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A<sub>2B</sub> …