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Showing 1 to 20 of 32 for “"A2A"”.
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The A2A adenosine receptor: its role in suppressing vascular inflammation and its regulation by phosphorylation
… adenosine are mediated by signalling through the A2AAR and activation of the A2AAR has been shown to be protective in numerous models of inflammatory disease. Little is known about the molecular mechanisms behind these effects. However, in vitro studies using cultured endothelial cells indicate …
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Mechanisms Mediating Modulation Of The Cardiopulmonary Chemoreflex Control Of Regional Sympathetic Outputs By Adenosine A1 And A2a Receptors In The Nts
<p>ABSTRACT</p> <p>by</p> <p>ZELJKA MINIC</p> <p>August 2013</p> <p>Advisor: Dr. Tadeusz J. Scislo</p> <p>Major: Physiology</p> <p>Degree: Doctor of Philosophy</p> <p>Adenosine is an important neuromodulator of cardiovascular control at the level of the nucleus of the solitary tract (NTS) where …
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Effects of chemogenetic inhibition of dopamine transporter- or A2A-expressing neurons on spontaneous activity and motivation to consume a palatable food reward
… have suggested that the release of DA onto D2+/A2A+-expressing striatopallidal neurons, plays a role in this process. To determine the potentially dissociable roles of DA-releasing ventral midbrain and striatopallidal neurons on motivational processes, we employed double transgenic mice that …
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Intra-nacc adenosine and its role in mediating palatable food intake: interactions with striatal opioids
… the intra-NAcc effects of selective A1 and A2A adenosine receptor ligands alone and when co-administered with the [mu]-opioid agonist DAMGO or the opiate antagonist naltrexone. The influence of the A1 receptor agonist CCPA, the A1 receptor antagonist DPX, the A2A receptor agonist CGS 21680, …
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Extracellular adenosine as a novel neuroimmune modulator
… either caffeine or by targeted antagonism of A1/A2A ARs. These findings suggest that anterograde amnesia after hypoxia/reoxygenation is reliant, in part, on IL-1β generated by AR-dependent activation of caspase 1 after reoxygenation. Next, we set out to investigate the signaling pathway in which …
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Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
… affinity at three targets, PDE10A, A1 and A2A receptors. In tandem, functional activity at the A2A receptor and PDE10A was investigated, resulting in the discovery of novel compounds, which exhibited anti-proliferative effects in lung carcinoma cell-lines correlating with the co-expression …
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Einfluß von Nukleotiden und Nukleosiden auf humane dendritische Zellen
… und P2Y11 sowie der Adenosinrezeptorsubtypen A1, A2a und A3 auf unreifen DCs. Nach LPS-induzierter Ausreifung der Zellen wurde die mRNA der P2Y-Subtypen sowie die der A2a-Rezeptoren von den DCs exprimiert. <br>Weiter konnte gezeigt werden, daß ADP, AMP und Adenosin konzentrationsabhängig eine …
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Neurochemische und autoradiographische Untersuchungen von Serotonin-Transporter-Knockout-Mäusen
… markierter Liganden für die Adenosin A1- und A2A-Rezeptoren, sowie für NMDA-, AMPA- und Kainat-Rezeptoren als Vertreter der ionotropen Glutamatrezeptoren durchgeführt. Bei der Untersuchung der Lipidperoxidation ergab sich ein signifikanter Anstieg des oxidativen Stresses im Hirnstammbereich – …
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Kardiovaskuläre Phänotypisierung von Angiotensin II AT2-Rezeptor- und adrenergen Rezeptor-"Knockout"-Mäusen
… ist mit erhöhten Plasmanoradrenalin-Spiegeln (a2A-KO), bzw. Plasmaadrenalin-Spiegeln (a2C-KO) assoziiert.
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The Effects of Nucleus Accumbens Opiate and Adenosine Receptor Activity on Appetitive Operant Learning
… nosepoking behavior. Activation of adenosine 2A (A2A) receptors impaired acquisition and performance of the operant task. Blockade of A2A receptors had no effect on either lever pressing or nosepoking behavior during either the learning or performance assessment periods. These novel data suggest …
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Deconstructing G Protein-Coupled Receptor Dimer Pharmacology: Case Studies in Dopamine D1 and D2 Receptors
… or other receptors (e.g. adenosine receptor A2A). Although a functional relevance for these dimers has been proposed, current assay systems are not capable of teasing out dimer-specific signaling events from those from other receptor populations. We have developed an assay that allows …
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Bloqueio adenosinérgico e filtro sensorial
… dos receptores de adenosina do tipo A1 e A2A) e a placebo, em dois momentos diferentes, tendo se avaliado os seus potenciais evocados de acordo com o paradigma do P50 antes (em seu valor basal) e após o tratamento, levantando-se uma curva de efeito com base no tempo. Paralelamente, …
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Hypoxic immunomodulation results in increased disease risk and altered behavior via non-canonical pathways
… potential activators such as K+ efflux and A2A adenosine receptor were administered. After glyburide (K+ efflux antagonist) and 3,7-dimethyl-1-prop-2-ynyl-purine-2,6-dione (DMPX-A2A adenosine receptor antagonist) administration, both drugs significantly reduced the level of caspase-1 …
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Immunodulation of inflammation in a murine pnemococcal sepsis model
… and anti-inflammatory effects mediated by A2A receptor (A2AR) expressed on immune cells. We investigated the effect of A2AR agonist, ATL313, as adjunctive therapy in a lethal C57bl/6 mouse model of systemic Streptococcus pneumoniae. Female C57bl/6 mice were inoculated intravenously with 107 …
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Advances in structure and small molecule docking predictions for crystallized G-Protein coupled receptors
… loops of four G-protein coupled receptors--the A2A adenosine, bovine rhodopsin, β1 and β2 adronergic receptors. For these cases, the loops were predicted in the context of a completely native crystal structure. In subsequent work the approach was extended to work on perturbed cases, where all …
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On the Integrability of Derivatives of Holomorphic and M-Subharmonic Inner Functions In the Unit Ball of Cn
… Dirichlet spaces, weighted Bergman spaces A2a for 0 < a < 1, and to the Ap spaces for 1 < p < 2. Moreover, it will be shown that if f is an inner function, n > 1, and either Rf belongs to B2n/(2n+1) , A3/2, or H1/2 then f must be constant. </p> <p>In addition to these results, we will also …
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Molecular Mechanisms Involved in Escherichia coli K1 and Haemophilus influenzae Type a Blood-Brain Barrier Impairment
… breakdown, highlighting the modulatory role of A2A and A2B adenosine receptors. In conclusion, association of an antibiotic therapy with a drug able to block the VEGFR-1 on pericytes could represent a novel strategy against E. coli K1 meningitis, while further studies on involvement of pericital …
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Avaliação do efeito do extrato de Fridericia Chica (Bonpl.) L.G Lohmann na neuroquímica de neurônio da retina
… através de quatro receptores chamados de A1, A2A, A2B e A3, que são acoplados a proteína G, e que, quando ativados, podem desencadear a ativação de vias de sobrevida celular, como as da ERK, CREB e Akt, assim como podem modular a liberação de neurotransmissores. Essas vias são descritas como …
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Priming of STAT1 and STAT3 for cytokine-triggered degradation by the proteasome upon A2Aadenosine receptor (A2AAR) expression
The A2A adenosine receptor (A2AAR) functions as a key non-redundant suppressor of inflammatory responses in vivo. However, whether it regulates activation of the JAK-STAT pathway utilised by many pro-inflammatory cytokines is unknown. Using a vascular endothelial cell model system, I have …
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