Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"A2780"”.
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Searching for Anticancer Natural Products From the Rainforest Plants of Suriname and Madagascar
… and screened for cytotoxic activity in the A2780 human ovarian cancer cell line. Fractionation of a leaf and flower extract of Casearia nigrescens led to the isolation of six new clerodane diterpenes. Four were new natural products and the other two were previously unreported hydrolysis …
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The cytotoxic effect of higher plant extracts on recurrent ovarian cancer cells
… out against two ovarian cancer cell lines (A2780 and A2780cis). The most toxic plant extracts where then used in a dose-response assay to show the potency of the natural products and to calculate the IC50. BIOLOG phenotypic microarray plates were then used to investigate the metabolism of …
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Isolation and Structure Elucidation of Antiproliferative Agents From Madagascar Rainforests
… two extracts which were active against the A2780 human ovarian cancer cell line and hence were selected for further fractionation. Six compounds were isolated from these extracts. The structure elucidation and characterization of these compounds was carried out using mass spectrometry and 1D …
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Isolation of Natural Products from Casearia nigrescens
… were screened for cytotoxicity using the A2780 human ovarian cancer cell line bioassay. The crude extract of Casearia nigrescens was fractionated and yielded five known compounds and one new compound that were cytotoxic. Mass spectrometry and 1D and 2D NMR techniques were used to determine …
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Studies on the synergic activity of a three-drug cocktail active against cisplatin-resistant human leukemia and carcinoma cells
… type and CDDP-resistant human ovarian carcinoma A2780 cells, and ex vivo cultures of human peripheral blood lymphocytes from healthy donors, were used as cell models to characterize the cytotoxic activity of both binary and ternary drug combinations. Experimental Design (ED) and Artificial Neural …
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Studies of Bioactive Natural Products and Mechanism-Based Bioassays
… binding assay. All compounds were active in the A2780 ovarian cancer cell line assay. Bioassay-guided fractionation of an extract of a sponge of species <i>Dysidea</i> using the A2780 bioassay yielded the known scalarane sesterterpenoid heteronemin in good yield. Four derivatives of heteronemin …
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Phytochemical, anti-cancer, anti-inflammatory and neuroprotective studies on compounds isolated from Malaysian plants, Aquilaria malaccensis and Hopea dryobalanoides
… Q/A and bala resulted in decreased viability of A2780 (ovarian) and ZR-75-1 (breast) cells in a concentration dependant manner. 7-Aca exhibited a more potent cytotoxicity against A2780 and ZR-75-1 cells (IC50=7.9µM and 8.5µM, respectively) compared to aca (IC50= 19.5µM and 17.5µM,respectively). …
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Design, Syntheses and Biological Activities of Paclitaxel Analogs
… their antiproliferative activities against the A2780 cell lines. Analogs 3.50-3.52 and 3.55 which were designed to adopt the T-taxol conformation showed similar antiproliferative activities compared to their open-chain counterparts. They were all much less active than paclitaxel. In the second …
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Isolation and Synthesis of Bioactive Compounds from Plants
… for their antiproliferative activity against the A2780 cell line, three plant extracts were investigated for their antimalarial activity against Plasmodium falciparum, and three plant extracts were investigated for their anti-inflammatory activity (PPAR-y inhibition). Bioassay-guided fractionation …
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Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis
… activity, along with their activity against A2780 human ovarian carcinoma and WHCO1 oesophageal cancer cell-lines.
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The Role of Gdf15 In Ovarian Cancer
… Furthermore, <em>in vivo</em> tumors formed with A2780 ovarian cancer cells in which GDF15 expression was suppressed, demonstrated a reduced percentage of stromal cells compared to tumors formed with control A2780 cells. The stromal percentage of the GDF15 knockdown tumors did not change following …
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INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3
… line models by exposing the platinum-sensitive A2780 cells to increasing concentrations of Carboplatin (CBP). The induction of platinum-resistance correlates with a decrease of H3K27me3, consistent with the findings from the clinical cohorts. Using a multi-omics approach, we investigated the …
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Circumventing Cisplatin Resistance In Ovarian Cancers Through Reactivation of P53 By Non-Cross-Resistant Platinum Analogs
… tumor panel composed of cis-Pt sensitive (A2780) and resistant (2780CP/Cl-16, OVCAR-10, HEY and OVCA 433) cell lines was established, with two (2780CP/Cl-16 and OVCAR-10) harboring missense mutant p53. The data obtained from these cancer cell lines have identified a correlation between …
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Searching for Anticancer Agents and Antimalarial Agents from Madagascar
… with antiproliferative activity against the A2780 human ovarian cancer line, and one extract with antimalarial activities was studied, which led to the isolation of five new natural products with antimalarial activities against the Dd2 and HB3 malarial parasites. The plants and their …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… moderate antiproliferative activity against the A2780 human ovarian cancer cell line assay with IC50 values of 3 uM and 10 uM, respectively. Compound 3.1 showed potent antiplasmodial activity with an IC50 value of 100 nM, while compounds 3.2 and 4.1 showed moderate antiplasmodial activity with …
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Isolation and Structure Elucidation of Cytotoxic Natural Products from Suriname and Madagascar
… from Suriname was weakly cytotoxic in the A2780 human ovarian cancer cell bioassay. The known benzophenone guttiferone A and a new guttiferone analog, named guttiferone G, were isolated from the extract and found to be responsible for the bioactivity. A known triterpene, friedelin, was also …
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Isolation, Synthesis and Structure-Activity Relationship Study of Anticancer and Antimalarial Agents from Natural Products
… with antiproliferative activity against the A2780 human ovarian cancer line. One extract with antimalarial activity was studied, which led to the isolation of two new natural products with antiplasmodial activity against a drug-resistant Dd2 strain of Plasmodium falciparum. The plants and …
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Isolation and Structure Elucidation of Antiproliferative and Antiplasmodial Natural Products from Plants
… moderate antiproliferative activity against the A2780 human ovarian cancer cell line with IC50 values of 6.9 uM and 3.4 uM, respectively. They also exhibited moderate antiplasmodial activity against chloroquine-resistant Plasmodium falciparum strain Dd2 with IC50 values of 9.9 ± 1.4 uM and 2.8 ± …
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Targeting RNA Structures with Multivalent Branched Peptide Libraries
… displayed little to no cytotoxicity in HeLa and A2780 cells.
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Chemical and molecular analysis of Libyan desert plants used in camel feed
… melanoma), PANC-1 (pancreatic carcinoma), A2780 (ovarian carcinoma), ZR-75-1 (breast carcinoma), LNCaP (prostate carcinoma), and HeLa (cervical cancer) and a non-cancer (PNT2) cell line using an AlamarBlue® assay. In parallel, this study also attempted to examine miRNAs present in the …
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