Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"A-to-I editing"”.
-
Small RNA and A-to-I editing in Autism Spectrum Disorders
… targets for intervention and prevention. Towards this goal, we surveyed adenosine-to-inosine (A-to-I) RNA editing in autistic brains. A-to-I editing is an epigenetic mechanism that fine-tunes synaptic function in response to environmental stimuli, shown to modulate complex behavior in …
-
THE ROLE OF ADARS-INTERACTING RNA HELICASES IN SHAPING THE RNA EDITOME IN CANCER
Adenosine-to-inosine (A-to-I) RNA editing, primarily catalysed by the ADAR family of proteins, is oftentimes dysregulated in cancers. However, the regulatory mechanisms controlling editing frequency in cancer cells remain largely elusive. Besides factors affecting the expression and activity of …
-
RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA
… IS A FAMILY OF ENZYMES CATALYSING ADENOSINE TO INOSINE CONVERSION (A-TO-I EDITING). IF HAPPENED IN CODING REGIONS, A-TO-I EDITING CAN CAUSE PROTEIN RECODING. RECODING EDITING HAS BEEN REPORTED TO CONTRIBUTE TO HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT. HOWEVER A-TO-I EDITING IS MOSTLY …
-
Knowledge bases, computational methods and data mining techniques with applications to A-to-I RNA editing, Synthetic Biology and RNA interference
… due obiettivi particolari tra i molti: da un lato, la costruzione di database biologici per memorizzare razionalmente sempre maggiori quantità di dati che divengono sempre più disponibili, e, dall'altro, lo sviluppo e l'applicazione di algoritmi al fine di estrarre pattern di predizione ed …
-
The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
… protein that deaminates adenosine (A) to inosine (I). A-to-I editing is an important post-transcriptional mechanism to prevent recognition of endogenous RNA by MDA5, a cytosolic RNA sensor. Activation of MDA5 by viral RNA can stimulate the innate immune system. Thus, ADAR-mediated RNA …
-
A-to-I RNA Editing in Human Cells
<p>RNA editing is a means of diversifying the transcriptome and regulating innate immunity. Among the different classes of enzymes that modify RNA, adenosine deaminase acting on RNA (ADAR) is a type that catalyzes adenosine-to-inosine editing on double-stranded RNA molecules to regulate cellular …
-
Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
… adenosine deaminases acting on RNA (ADAR). ADAR editing activity is known to play a key role in modulating the host cell’s immune response to RNA. Here, we specifically study the effect of the presence of inosine in RNA by generating an inosine-containing reporter mRNA sequence. We also generated …
-
Are Post-Transcriptional RNA Modification Events in the Glutamate-Gated and GABA-Gated Chloride Channels of Anopheles minimus and Anopheles dirus associated with Ivermectin Insensitivity?
Mosquito-borne diseases, most notably malaria, have been a constant public health challenge in many regions around the world claiming the lives of hundreds of thousands every year. Vector control strategies such as insecticide use were initially effective in reducing malaria transmission. However, …
-
Next-generation sequencing analysis and RNA editing in human brain and glioma
… is one of the most common technologies in use today for the analysis of gene expression and transcriptome variation in biological samples (Zhong Wang et al. 2009). As of 2011, the NCBI Sequence Read Archive (SRA) surpassed 100 terabases of sequence data, comprising nearly 40,000 RNA and 260,000 …