Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"A to I"”.
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A-to-I RNA Editing in Human Cells
… editing is a means of diversifying the transcriptome and regulating innate immunity. Among the different classes of enzymes that modify RNA, adenosine deaminase acting on RNA (ADAR) is a type that catalyzes adenosine-to-inosine editing on double-stranded RNA molecules to regulate cellular …
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Small RNA and A-to-I editing in Autism Spectrum Disorders
… targets for intervention and prevention. Towards this goal, we surveyed adenosine-to-inosine (A-to-I) RNA editing in autistic brains. A-to-I editing is an epigenetic mechanism that fine-tunes synaptic function in response to environmental stimuli, shown to modulate complex behavior in …
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Knowledge bases and stochastic algorithms for mining biological data: applications on A-to-I RNA editing and RNAi
Fino alla seconda metà del Novecento, il rapporto tra la Biologia e l Informatica era molto flebile e i dati venivano generalmente raccolti su materiali deperibili come la carta e stipati in schedari. Questa situazione è cambiata grazie all avvento della Bioinformatica, un campo relativamente …
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Knowledge bases, computational methods and data mining techniques with applications to A-to-I RNA editing, Synthetic Biology and RNA interference
… due obiettivi particolari tra i molti: da un lato, la costruzione di database biologici per memorizzare razionalmente sempre maggiori quantità di dati che divengono sempre più disponibili, e, dall'altro, lo sviluppo e l'applicazione di algoritmi al fine di estrarre pattern di predizione ed …
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THE ROLE OF ADARS-INTERACTING RNA HELICASES IN SHAPING THE RNA EDITOME IN CANCER
Adenosine-to-inosine (A-to-I) RNA editing, primarily catalysed by the ADAR family of proteins, is oftentimes dysregulated in cancers. However, the regulatory mechanisms controlling editing frequency in cancer cells remain largely elusive. Besides factors affecting the expression and activity of …
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RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA
… IS A FAMILY OF ENZYMES CATALYSING ADENOSINE TO INOSINE CONVERSION (A-TO-I EDITING). IF HAPPENED IN CODING REGIONS, A-TO-I EDITING CAN CAUSE PROTEIN RECODING. RECODING EDITING HAS BEEN REPORTED TO CONTRIBUTE TO HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT. HOWEVER A-TO-I EDITING IS MOSTLY …
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The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
… protein that deaminates adenosine (A) to inosine (I). A-to-I editing is an important post-transcriptional mechanism to prevent recognition of endogenous RNA by MDA5, a cytosolic RNA sensor. Activation of MDA5 by viral RNA can stimulate the innate immune system. Thus, ADAR-mediated RNA …
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Reflexe realismu v srbském dramatu
… zmapovat srbské dramatické prostředí během 19. století, především období realismu. Pokoušíme se zachytit jeho počátky, klíčové realistické prvky a jeho nejdůležitější rysy. Pozornost je zaměřena také na hlavní představitele a díla Branislava Nušiće a Petara Kočiće. Práce se snaží rovněž …
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CSR aktivity Tesco Stores ČR a.s. v letech 2009-2010
… na společensky odpovědné aktivity Tesco Stores ČR a. s. v letech 2009 - 2010, zasazuje je do kontextu marketingové komunikace a analyzuje je pomocí tří základních pilířů CSR - ekonomického, sociálního a environmentálního. Nejprve je popsáno, co koncept CSR je, jak vzniknul, které složky …
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Google Econometrics: An Application to the Czech Republic
Tato diplomová práce se zabývá aplikovatelností 'Google ekonometrie' - nebo- li využitím dat o objemech vyhledávání určitých hesel jako vysvětlujících proměnných při modelování časových řad - v případě České republiky. Přínos Google dat analyzujeme za pomoci srovnání jak přesnosti 'out-of-sample' …
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Autorskoprávní ochrana počítačových programů
… otázce vhodnosti ochrany počítačových programů autorským právem a jejich podřazení režimu děl literárních, je tento způsob ochrany v současnosti univerzálně uznáván a zakotven v řadě mezinárodních a nadnárodních dokumentů. Při každém pořízení počítačového programu je tak třeba mít důsledně na …
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Organic Cation Transporter 3 (OCT3/SLC22A3) and Multidrug and Toxin Extrusion 1 (MATE1/SLC47A1) Protein in the Placenta: Expression, Localization and Function
… v Hradci Králové Katedra Pharmacology and Toxicology Kandidát Mgr. Davoud Ahmadimoghaddam Školitel Prof. PharmDr. František Štaud, Ph.D Název disertační práce Organic cation transporter 3 (OCT3) a multidrug and toxin extrusion protein 1 (MATE1) v placentě: exprese, lokalizace a funkce. …
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Podmínky přijetí nevlastního otce dítětem a život ve složené rodině očima dětí a nevlastních otců
… zda má výchovný styl a případně další faktory vliv na přijetí nevlastního otce, a c) zmapovat kvalitativně život ve složené rodině z pohledu dětí i nevlastních otců. Na základě provedeného výzkumu je možné konstatovat, že děti ze složených rodin akceptují svého nevlastního otce, s nímž …
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Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
… on RNA (ADAR). ADAR editing activity is known to play a key role in modulating the host cell’s immune response to RNA. Here, we specifically study the effect of the presence of inosine in RNA by generating an inosine-containing reporter mRNA sequence. We also generated mRNA sequences that …
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Are Post-Transcriptional RNA Modification Events in the Glutamate-Gated and GABA-Gated Chloride Channels of Anopheles minimus and Anopheles dirus associated with Ivermectin Insensitivity?
Mosquito-borne diseases, most notably malaria, have been a constant public health challenge in many regions around the world claiming the lives of hundreds of thousands every year. Vector control strategies such as insecticide use were initially effective in reducing malaria transmission. However, …
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Modeling Autism Spectrum Disorder: Fragile X syndrome and Rett syndrome
… associated with broad health complications that together carry lifelong impact. Unfortunately, ASD symptoms occur at the nexus of higher-order cognitive functions, which arise through inordinately complex cellular and molecular processes. This pleiotropic nature means that, in many cases, ASD …
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Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
… such as alternative splicing have been shown to add to the complexity needed to compensate for the relatively low number of genes found in higher organisms. Many other modifications recently found in mRNA, which cannot be deduced from what is coded in the genome, such a cytidine to uridine and …
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Next-generation sequencing analysis and RNA editing in human brain and glioma
… is one of the most common technologies in use today for the analysis of gene expression and transcriptome variation in biological samples (Zhong Wang et al. 2009). As of 2011, the NCBI Sequence Read Archive (SRA) surpassed 100 terabases of sequence data, comprising nearly 40,000 RNA and 260,000 …