Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Aβ1-42"”.
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Recombinant production of Aβ1-42 peptide and analysis of interactions between Aβ1-42 and Peptide Inhibitor NanoParticles (PINPs) developed as a potential novel treatment for Alzheimer’s Disease
… study addressed two main aims relating to the Aβ1-42 peptide – widely demonstrated to play a key role in the pathogenesis of Alzheimer’s Disease (AD). Aβ1-42 is an amyloid peptide that readily self-associates forming neurotoxic aggregates. With the primary risk factor for AD being age, and …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
… at unraveling the complex formation between Aβ1-42, apoE, FH, and C1q, and their role in complement activation to provide novel insights on the mechanisms contributing to AD pathophysiology. By conducting enzyme-linked immunosorbent assays and Western Blotting of native PAGE, I was able to …
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Field Amplified Sample Stacking on Amyloid Beta (1-42) Oligomers using Capillary Electrophoresis
… to provide higher resolution in oligomeric Aβ1-42 detection without causing significant changes to the aggregation. It was observed that the FASS technique provided smaller peak widths and increased peak heights on the CE compared to the non-FASS conditions. Furthermore by conducting …
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Insulin, Cholesterol and A-beta: Roles and Mechanisms in Alzheimer’s disease
… inhibiting signaling to downstream targets. Aβ1-42-treated SHY exhibited similar IRS-1 phosphorylation at Ser612 and inflammatory response of JNK activation. Aβ1-42 caused down-regulation of neuro-protective/anti-inflammatory DHCR24, and an increase in HMGCR levels indicating dysregulation of …
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Using cannabidiol and trazodone to treat protein misfolding neurodegenerative disease in C. elegans
… of the misfolded proteins Amyloid-Beta (Aβ1-42) and/or hyperphosphorylation of Tau (p-Tau). Despite the lack of a cure for the disease, it is well known that targeting signaling pathways involved in reactive oxygen species (ROS) or the unfolded protein response (UPR) mitigates the toxic …
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Investigating the therapeutic potential of cannabidiol for Alzheimer’s disease: Using Caenorhabditis elegans that express the amyloid-beta protein
… that the accumulation of the amyloid-beta (Aβ1–42 ) protein is the causative agent. AD has no cure and current treatments provide limited therapeutic benefits. Cannabidiol (CBD) is a cannabinoid derived from Cannabis plants that has neuroprotective, anti-inflammatory, and antioxidant …
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Das zelluläre Prionprotein im Liquor cerebrospinalis von Patienten mit verschiedenen neurologischen Erkrankungen
… der bereits klinisch etablierten Biomarker Aβ1-42 und Tau-Protein als Markerprotein in der Diagnostik neurodegenerativer Erkrankungen Verwendung finden. Interessanterweise konnten in dieser Arbeit einige signifikante Korrelationen zwischen diesen beiden Biomarkern und PrPc gefunden werden.
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An overview of blood-based biomarkers in AD
… the levels of specific AD-related biomarkers (Aβ1-42, Aβ1-40, t-tau, p-tau181, glial fibrillary acidic protein (GFAP) and neurofilament light chain (NFL)) in two different cohorts. Our results have indicated that Aβ1-42/Aβ1-40 ratio, p-tau181 and GFAP levels are reliable biomarkers for …
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Investigation of amyloid-β aggregates derived from light-triggered nitration: relevance for Alzheimer’s disease [Indagine sugli aggregati di amiloide-β derivanti dalla nitrazione indotta dalla luce: rilevanza per la malattia di Alzheimer]
… una nitrazione selettiva e parafisiologica di Aβ1-42, dimostrando che i monomeri nitrati non si aggregano in oligomeri tossici di basso peso molecolare, ma si assemblano in grandi aggregati amorfi privi di neurotossicità, che inducono un fenotipo microgliale fagocitico. Parallelamente, abbiamo …
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Neuronal Protection by a Novel C-terminal Hsp90 Modulator
… which protects primary cortical neurons against Aβ1-42, a toxic peptide found in AD brain. Pharmacokinetic studies indicated that KU-32 is blood brain barrier permeable and orally bioavailable. Using two AD mouse models, JNPL3 and rTg4510, which both contain the P301L Tau mutation and develop …
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Photobiomodulation with IR1072nm in the murine CNS: in vitro and in vivo studies
… binding sites in CD-1 mice, and reduced total Aβ1-42 expression and small amyloid plaque counts (in cortex and dentate gyrus) in TASTPM mice, was observed. Overall, this thesis reveals new mechanisms of photobiomodulation with IR1072 which involves restoring cellular homeostasis for optimal …
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ROLE OF LECITHIN:CHOLESTEROL ACYLTRANSFERASE (LCAT) IN BRAIN CHOLESTEROL METABOLISM AND ITS INVOLVEMENT IN ALZHEIMER¿S DISEASE
… observed between plasma UC and UC/TC ratio with Aβ1-42 CSF content. Cholesteryl esters composition in CSF of AD revealed significant enrichment in saturated fatty acids (FA) and monounsaturated FA and a depletion in polyunsaturated FA in cholesterol species compared to controls. Specifically, …
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Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology
… NIR light. We found a significant reduction of Aβ1-42 at the synapses of NIR light treated APP transgenic (Tg2576) and 3xTg-AD mice. Further, 3xTg-AD and htau mice had reduced tau oligomers at the synapses and in the total protein extract after NIR light treatment. We further found a reduction …
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CHRONIC STRESS REVEALS COGNITIVE IMPAIRMENT IN A SUBTHRESHOLD AMYLOID-BETA MODEL OF ALZHEIMER’S DISEASE
… by continuous i.c.v. infusion of 160 pmol/day Aβ1-42 via a 14-day mini-osmotic pump. Behavioral tests, electrophysiological recordings, and molecular analyses showed that subAβ rats were not significantly different from control rats, thus validating this model as an at-risk model of AD without …
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Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses
… as it prevents the detrimental effects of Aβ1-42; a pathological hallmark of Alzheimer’s disease (AD; Shankar et al., 2008), on synaptic plasticity at TA-CA1 synapses.<br/><br/>Taken together, our overall findings clearly demonstrate that the endocannabinoid system has divergent effects on …
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USING B-STRAND AND B-HAIRPIN PEPTIDOMIMETICS INDUCED BY CONSTRAINED AMINO ACIDS TO MODULATE THE AGGREGATION OF THE MICROTUBULE ASSOCIATED PROTEIN TAU: DESIGN, SYNTHESIS AND EVALUATION
… act as dual inhibitors targeting both Tau and Aβ1-42 proteins but show no activity on the other amyloid protein hIAPP. These compounds were designed either on Tau PPIs, by mimicking its self-interaction in NFTs or its physiological interaction with MTs; or on small sequences of the chaperone …