Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 215 for “"Aβ"”.
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
Alzheimer's Disease (AD) is a progressive, age-related disease that is positively characterised by the post-mortem presence of neurofibrillary tangles and amyloid plaques. At present ~ 5 % of those aged over 65 years are diagnosed with AD, with this figure increasing to ~ 20 % for those aged over …
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Quantitative Proteomics Analysis of Differentially Expressed Proteins in Aβ(17-42) Treated Synaptosomes
… DS patients have an extensive deposition of Aβ(17-42) peptide, which could contribute to their increased rate of developing Alzheimer's disease (AD). Since AD cannot be properly diagnosed until autopsy, development of a novel Down syndrome model using Aβ(17-42) could be beneficial in …
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Implantable device for Aβ immunoselective nanopheresis in the cerebrospinal fluid to treat Alzheimer’s Disease
… IT a largo plazo de anticuerpos anti-Aβ mediante sustitución percutánea de la solución terapéutica en el modelo murino de EA APP/PS1 en fase sintomática temprana.
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Dynamic Measurement Of Soluble Human Aβ In A Combined Microdialysis-Experimental Traumatic Brain Injury Mouse Model
The amyloid-β peptide: Aβ) plays a central pathophysiological role in Alzheimer's disease, but little is known about its dynamics in the brain's extracellular space. A recent microdialysis-based study in human patients with severe brain injuries found that extracellular Aβ dynamics …
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Regulation of Tau gene expression by Aβ and the amyloid precursosr protein in cultured cortical neurons
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
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Restoring the balance in the kinetic network of Aβ aggregation as a drug discovery strategy for Alzheimer’s Disease
… with the aggregation of the amyloid-β peptide (Aβ). Even though a variety of strategies has been developed towards inhibiting the aggregation of Aβ, no disease-modifying treatment has so far reached the clinic. This failure is in part due to i) an incomplete knowledge of the aggregation process …
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Identification And Characterization Of Mediators Of Toxicity Of Aβ Oligomers By Genome Wide Screening In <i>Caenorhabditis Elegans</i>
Soluble oligomers of the amyloid-β (Aβ) protein play a key role in the pathogenesis of Alzheimer’s disease (AD), although the underlying molecular mechanisms are poorly understood. In order to search for proteins involved in the formation and/or toxicity of Aβ oligomers, a transgenic <i>C. …
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
<p>The importance of amyloid-beta (Aβ) in the development and progression of Alzheimer’s disease (AD) is currently well-recognized. Aβ was recently shown to be protective against certain types of cancer and capable of inhibiting the growth of tumor cells. The mechanisms by which Aβ is converted …
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Angiotensin-converting enzyme cleavage of the Alzheimer's beta-amyloid peptide
… been shown that ACE hydrolyses the amyloid beta (Aβ) peptide, the putative causative agent of AD. This study aimed to investigate the molecular basis of ACE hydrolysis of Aβ by determining : 1) the kinetic parameters of five different forms of human ACE with various N-terminal amyloid beta (Aβ) …
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Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease
… and deposition of the amyloid-β peptide (Aβ) and the aggregation of hyperphosphorylated tau protein, respectively. Aβ is formed upon sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases and is secreted extracellularly. The accumulation of extracellular Aβ is …
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The effects of catalase and kisspeptin overexpression on amyloid peptide toxicity
Amyloid β (Aβ) is the major component of the senile plaques in Alzheimer’s disease (AD). The mechanism underlying cell death in AD includes oxidative stress, apoptosis, impaired mitochondrial function and receptor mediated effects. Compounds that specifically bind to Aβ are neuroprotective. …
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Structural Characterization of Plaque Seeded Amyloid-β Fibrils by Magic Angle Spinning NMR
… of amyloid fibrils of the peptide amyloid-β (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). Aβ is prone to polymorphism and the structure of fibrils is sensitive to the conditions under which they are formed. The two dominant forms of Aβ are Aβ₁₋₄₀ and Aβ₁₋₄₂. Aβ₁₋₄₂ is …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… disease (AD) are amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE levels is not clearly …
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Cerebral Amyloid Angiopathy-Causing Beta-Amyloid Variants Have Altered Effects on the Clotting System
… amyloid angiopathy (CAA), where beta-amyloid (Aβ) deposits around cerebral blood vessels, is a major contributor of vascular dysfunction in Alzheimer's disease (AD) patients. However, the molecular mechanism underlying CAA formation and CAA-induced cerebrovascular pathologies, including …
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Vascular changes in Alzheimer’s disease and other types of dementia in the retina of human and animal
… AD. Recent research has shown that amyloid beta (Aβ); the protein responsible for cerebral amyloid plaques in AD may also accumulate within the retina in those affected by the condition. My research involved the application of immunohistochemistry techniques to identify Aβ within the retina of AD …
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Studying Models of the Amyloid Cascade Hypothesis Using Single-Molecule Imaging
Observation of beta-amyloid (Aβ) plaques in the brains of Alzheimer’s disease (AD) patients led to the development of the amyloid cascade hypothesis (ACH), which postulates the accumulation of Aβ as the initiator of AD. Aβ can be found in multiple forms in the AD brain; while the insoluble plaques …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
<p>Amyloid-beta (Aβ) aggregation and deposition into extracellular plaques is a hallmark of the most common forms of dementia, including Alzheimer’s disease. The Aβ-containing plaques result from pathogenic cleavage of amyloid precursor protein (APP) by secretases resulting in intracellular …
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… are composed of aggregated amyloid-β protein (Aβ), which is widely believed to be the underlying cause of the disease. Mounting evidence suggests the small, soluble aggregates of Aβ induce the progressive neurodegeneration observed in AD patients. AD patients also display varying degrees of …
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