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Showing 1 to 2 of 2 for “"8F4"”.
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… PR1 cellular therapy<sup>2,3</sup> and 8F4, a T cell receptor (TCR)-like monoclonal antibody (mAb)<sup>4,5</sup>.</p> <p>One possible source of NE and P3 in the microenvironment is neutrophil extracellular traps (NETs). NETs are composed of deoxyribonucleic acid (DNA)/histones extruded …
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Modulating Avidity of H8F4-Car By Regulation of Expression Via Codon Modification
… of a TCR-like monoclonal antibody named 8F4 and its adaptation into a chimeric antigen receptor (CAR) named h8F4-CAR. As PR1/HLA-A2 is a self-antigen, its targeting renders increased susceptibility to on-target, off-tumor effects which is a common adverse effect seen in other CAR …