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Showing 1 to 4 of 4 for “"8-oxo-2'-deoxyguanosine"”.
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Chemical synthesis of isotopically labelled (M+4) purine nucleosides and their incorporation into DNA oligomers
… to measure the level of biomarkers, such as 8-oxo-guanine or its corresponding nucleoside, 8-oxo-2’-deoxyguanosine, has become imperative in the study of DNA oxidative damage in vivo. Of the most promising techniques, HPLC-MS/MS, has many attractive advantages. Like any method that employs the …
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Consequences of Oxidative DNA Damage: Base-Pair Dissociation, Singlet Oxygenation and DNA-Protein Crosslinking
<p>8-Oxo-2′-deoxyguanosine (OG) is a common DNA lesion resulting from oxidatively generated damage and pairs with complementary cytidine (C) in Watson Crick base-pairing within duplex DNA. The WC-OG·C lesion, if not recognized or repaired, not only leads to G⋅C→T⋅A transversion mutations (through …
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Investigation into the toxicity and DNA interactive properties of a range of cationic photosensitisers with potential application to photodynamic antimicrobial chemotherapy
… product of DNA oxidative damage is 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodG) but treatment of phage A DNA with the PhBPs failed to produce an increase upon illumination, implying that the production of 8-oxodG may not generally be a major form of damage induced by the photo-toxic action of the …
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Altered DNA Repair, Antioxidant and Cellular Proliferation Status as Determinants of Susceptibility to Methylmercury Toxicity in Vitro
… virus 40 (SV40) large T antigen-immortalized oxoguanine glycosylase 1-null (Ogg1-/-) murine embryonic fibroblasts (MEFs); and, (2) human Ogg1 (hOgg1)- or formamidopyrimidine glycosylase (Fpg)-expressing human embryonic kidney (HEK) cells; reciprocal in vitro cellular models with deficient and …