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Showing 1 to 11 of 11 for “"8-hydroxy-2'-deoxyguanosine"”.
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
8-hydroxy-2'-deoxyguanosine DNA glycosylase is the first step and rate-limiting enzyme involved in the removal of 8-hydroxy-2'-deoxyguanosine via the base excision repair pathway. Transcriptional regulation of human Ogg1 is sensitive to redox changes via modulation of intracellular glutathione. In …
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Disruption of 8-hydroxy-2'-deoxyguanosine DNA Glycosylase (OGG1) Antioxidant Response Capacity by Sodium Arsenite
8-hydroxy-2'-deoxyguanosine DNA glycosylase is the first step and rate-limiting enzyme involved in the removal of 8-hydroxy-2'-deoxyguanosine via the base excision repair pathway. Transcriptional regulation of human Ogg1 is sensitive to redox changes via modulation of intracellular glutathione. In …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… DNA damage was based on urinary and muscle 8-hydroxy-2'-deoxyguanosine. Post-exercise proteinuria was determined with several biomarkers including urinary total protein, albumin, beta2-microglobulin, N-acetyl-beta-D-glucosaminidase, and creatinine. The overall results showed that there were …
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Effects of Long-term Strenuous Exercise on Oxidative DNA Damage and Proteinuria in Humans
… DNA damage was based on urinary and muscle 8-hydroxy-2'-deoxyguanosine. Post-exercise proteinuria was determined with several biomarkers including urinary total protein, albumin, beta2-microglobulin, N-acetyl-beta-D-glucosaminidase, and creatinine. The overall results showed that there were …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
… (G) moiety, yielding the oxidized lesion 8-hydroxy-2'-deoxyguanosine (oxo82dG), in DNA has become a hallmark biomarker in assessing cellular outcomes induced by oxidative stress. It is well established that the guanosine nucleotide triphosphate pool is also susceptible to oxidative stress …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
… of oxidative stress including formation of 8-hydroxy-2'-deoxyguanosine (8-oxo-2dG), an indicator of oxidative DNA damage, and depletion of reduced glutathione (GSH) were examined using an HPLC-based method and a colorimetric assay, respectively. Induction of apoptosis was examined using a …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
… (G) moiety, yielding the oxidized lesion 8-hydroxy-2'-deoxyguanosine (oxo82dG), in DNA has become a hallmark biomarker in assessing cellular outcomes induced by oxidative stress. It is well established that the guanosine nucleotide triphosphate pool is also susceptible to oxidative stress …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
… of oxidative stress including formation of 8-hydroxy-2'-deoxyguanosine (8-oxo-2dG), an indicator of oxidative DNA damage, and depletion of reduced glutathione (GSH) were examined using an HPLC-based method and a colorimetric assay, respectively. Induction of apoptosis was examined using a …
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An Evaluation of exposures to respirable particulates, environmental PM2.5, PAHs and metal compounds in Western Australia
… the levels of detection. Urinary levels of 1-hydroxypyrene (1-OHpy) were below the level of detection. Copper, selenium and nickel were present in urine samples and these were not significantly different between locations, nor was there any correlation with residential areas within study …
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Evaluation of suboptimal health status and prospective levels of oxidative stress biomarkers and angiogenic growth mediators with placental anatomy and pathology in normotensive and preeclamptic births
… (8-epiprostaglandinF2 alpha [8-epi-PGF2α], 8-hydroxy-2-deoxyguanosine [8-OHdG] and total antioxidant capacity [TAC]) were evaluated across the 4-time sampling periods (10-20, 21-31, 32-42 weeks, and 48 hours-2 weeks postpartum) using ELISA. Placenta tissues were collected after delivery and …
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Oxidative Stress and Inflammation in the Heterogeneity of Metabolic Health
Metabolic health is determined by complex biological processes that extend beyond anthropometric indicators such as body mass index (BMI). Chronic low-grade inflammation and oxidative stress are key mechanisms linking metabolic dysfunction to cardiometabolic disease, but their interaction across …