Global ETD Search
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Showing 1 to 19 of 19 for “"8-OH-DPAT"”.
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Estudio de síntesis de 2-[oxoalquil](4-arilpiperazinil)]-benzo[b]tiofenos sustituidos : evaluación de su afinidad serotoninérgica mediante ensayos de competencia frente A [3H]-8-OH-DPAT
… a 8-hidroxi-2-(N,N-di-n-propilamino)tetralina (8-OH-DPAT) se evaluó in Vitro mediante estudios de competencia frente a [3H]-8-OH-DPAT utilizando membranas de corteza cerebral de rata. Los compuestos 1-(benzotiofen-2-il)-3-(4-(piridin 2-il)piperazin-1-il)propan-1-ona (2.27) y …
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Estrogen and 5-HT(1A) receptor function
… 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited lordosis behavior. However, when rats were given a second estradiol benzoate injection (seven days later) followed by progesterone, the ability of 8-OH-DPAT to inhibit lordosis behavior was reduced. The reduction in the ability …
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Estrogen and 5-HT(1A) receptor function
… 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT), inhibited lordosis behavior. However, when rats were given a second estradiol benzoate injection (seven days later) followed by progesterone, the ability of 8-OH-DPAT to inhibit lordosis behavior was reduced. The reduction in the ability …
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Hindbrain Serotonin Neurons Activate 5-HT1A Receptors in the Nucleus Tractus Solitarius (NTS) to Modulate Sympathetic and Ventilatory Recovery Following Hypotensive Hemorrhage
… lab has found that 5-HT1A-receptor agonist, 8-OH-DPAT, increases perfusion pressure and improves acid-base balance in hypovolemic rats by stimulation of sympathetic-mediated increases in venous tone. These data suggest that 8-OH-DPAT may be a promising adjuvant agent in resuscitation. We have …
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Activation of 5-HT1A Receptors in the Nucleus Tractus Solitarius Facilitate Ventilatory Responses to Hypoxic Hypercapnia and Promote Sympathetic Recovery Following Hypotensive Hemorrhage
<p>The 5-HT<sub>1A</sub> receptor agonist, 8-OH-DPAT, improves recovery from hemorrhage by stimulating sympathetically-mediated venoconstriction and cardiac output. The sympathoexcitatory effect of 8-OH-DPAT is only observed in hypovolemic rats, and is attenuated by sinoaortic denervation. Lesion …
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THE ROLE OF PIAS PROTEINS IN THE SUMOYLATION OF 5-HT1A RECEPTORS
… (+)-8-Hydroxy-2-dipropylaminotetralin ((+)8-OH-DPAT) and was further enhanced by combination of treatment of 17β-estradiol-3-benzoate (EB) and 8-OH-DPAT. Identifying the mechanism involved in SUMOylation of 5-HT1A Rs will be important for understanding the regulation of 5-HT1A Rs, which will …
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Expression and function of serotonin receptor isoforms in the respiratory system
… steigert und Opioid-induzierte Atemdepression ohne Verlust der Analgesie kompensiert werden kann. Der Erhalt der Analgesie läßt sich anhand der fehlenden Expression des 5-HT4(a)R in Neuronen des Hinterhorns erklären. Weiterhin konnte gezeigt werden, daß die 5-HT1A, 5-HT7 und µ-Opioid Rezeptoren …
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5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
… investigated whether the 5-HT[1A] agonist 8-OH-DPAT, inhibited forskolin stimulated Ca[2+] release in the SHSY-5Y cell line and whether the 5-HT[1A] antagonist p-MPPI reversed this effect using flow cytometry. The post-mortem study showed that the G-1019 allele had significantly higher …
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Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor
… studies using the selective 5HT1aR agonist [3H]8-OH-DPAT. Peptides P21 to P23 uncoupled the G protein from the receptor to 50% of control. Peptides P24 to P27 uncoupled the G protein from the receptor to 6-15% of control. Peptide capacity to alter signal transduction was measured using …
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Structure Activity Relationships for Intracellular Loop 2 of the 5HT1A Serotonin Receptor
… studies using the selective 5HT1aR agonist [3H]8-OH-DPAT. Peptides P21 to P23 uncoupled the G protein from the receptor to 50% of control. Peptides P24 to P27 uncoupled the G protein from the receptor to 6-15% of control. Peptide capacity to alter signal transduction was measured using …
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3,4-Diaminopyridin evozierte Freisetzung von Neurotransmittern aus Hirnschnitten von Ratten
… ergaben sich folgende Resultate: <br>1. Sowohl bei denen mit [³H]5-HT, wie auch bei denen mit [³H]NA und [³H]ACh beladenen Hirnschnitten erwies sich die 3,4-DAP evozierte Freisetzung als Tetrodotoxin-sensitiv und abhängig von der extrazellulären Kalziumkonzentration. Es wurde damit gezeigt, …
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Prenatal stress alters fear-conditioned behaviors and the response to serotonergic drugs
… systemic doses of the 5-HT 1A agonist, 8-OH-DPAT, compared to CON rats. The PS rats had shorter latencies than the CON rats under vehicle treatment.;In fear-potentiated startle testing, peak startle responding did not reach the same levels in the PS rats as it did in the CON rats; thus, it …
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5HT 2 Rezeptor vermittelte Kontrolle des neonatalen medullären respiratorischen Netzwerks des Säugers
… Applikation des 5HT 1A Rezeptor Agonisten 8 OH DPAT resultierte in einer Erhöhung des Eingangswiderstands und einer Depolarisation des Membranpotentials. Die iontophoretische Applikation des 5HT 2A Rezeptor Agonisten a-Methyl 5HT hatte eine Depolarisation verbunden mit einer Reduktion des …
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Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
… > 5-HT > 5-MeOT » L-694, 247 > CGS 12066A > 8-OH-DPAT. In human iris-ciliary bodies, both 5-HT and m-CPBG had excitatory effect on evoked [3H]-5-HT release, however this tissue was less sensitive to the effects of these agonists than bovine tissue. The agonists selective for 5-HT6/7 and 5-HT3 …
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Aspects of tic like behaviour and serotonergic control
… fore-paw-tremor. The 5-HT1A agonists 8-OH DPAT and buspirone attenuated blinking at the lower doses tested but were ineffective at the higher doses; the converse was found for fore-paw-licking and -tremor behaviours.The effects of these ligands appeared to be at a postsynaptic 5-HTlA …
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Charakterisierung der Serotonin-Rezeptoren der Honigbiene Apis mellifera : von den Genen zum Verhalten
Das serotonerge System besitzt sowohl bei Invertebraten als auch bei Vertebraten eine große Bedeutung für die Kontrolle und Modulation vieler physiologischer Prozesse und Verhaltensleistungen. Bei der Honigbiene Apis mellifera spielt Serotonin (5-Hydroxytryptamin, 5-HT) eine wichtige Rolle bei der …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… classes of 5-HT1A receptor agonists. (+)8-OH-DPAT (an aminotetralin), acted as a "full" agonist on each of the respective pathways, while tandospirone (an azapirone) exhibited "partial" agonist activity on activation of Akt but exhibited "full" agonist activity on neuroendocrine responses …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
… agonists, 5-CT (5-HT1A/7 receptor agonist) and 8-OH-DPAT (5-HT1A receptor agonist) at a concentration range of 10nM-0.1mM, indicating the unlikely involvement of 5-HT1A and 5-HT7 receptors in the mediation of contractile responses in the neonatal rat ileum. Results indicate differences in …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
… agonists, 5-CT (5-HT1A/7 receptor agonist) and 8-OH-DPAT (5-HT1A receptor agonist) at a concentration range of 10nM-0.1mM, indicating the unlikely involvement of 5-HT1A and 5-HT7 receptors in the mediation of contractile responses in the neonatal rat ileum. Results indicate differences in …