Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"8-17 DNAzyme"”.
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Development of functional DNA-based sensors and investigations into their mechanism
… DNA molecules also known as deoxyribozymes or DNAzymes were first isolated in 1994 through an in vitro selection procedure and have since been engineered and isolated to perform various functions that include both RNA and DNA cleavage and ligation. The 8-17 DNAzyme is an RNA-cleaving DNAzyme …
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Functional dna: Biochemical/biophysical characterization & sensing applications
… tied together through the common thread of the 8-17 DNAzyme and involve biochemical and biophysical characterization of the 8-17 DNAzyme as well as characterization of a novel red Pb2+ species formed upon cleavage of a modified 8-17 DNAzyme. Determination of the enantiomeric ratio is important as …
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In Vitro Selection and Characterization of Highly Selective Metal -Dependent DNAzymes With Potential Biosensor Applications
… the secondary structures of the resulting DNAzymes with the structure of the 8-17-like DNAzymes, which were selected through three independent experiments in the presence of: (1) Zn2+, (2) Mg2+, and (3) histidine plus Mg2+. The DNAzymes obtained from this experiment did not appear to …
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Investigation of Metal-Dependence in DNAzymes and Applications of DNAzymes and Aptamers for Diagnostics
… in diagnostics and sensing were examined using DNAzymes and aptamers. Aptamers are nucleic acids which bind a specific chemical or biological moeity. By labeling DNAzymes and aptamers with colored gold nanoparticles, our laboratory had previously constructed colorimetric sensors for analytes …
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Applications of functional nucleic acids in imaging, sensing and drug delivery and investigations of DNAzyme-metal interactions
… including nucleic acids catalysts (ribozymes and DNAzymes) and ligands (aptamers), have been discovered in nature or isolated in a laboratory through a process called in vitro selection. They are nucleic acids with functions similar to protein enzymes or antibodies. They have been developed into …
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I. In vitro selection of aptamers for perchlorate and melamine II. Towards crystallization of DNAzymes III. A highly selective lead sensor based on a classic lead DNAzyme
… of functional nucleic acids, catalytic DNA (DNAzyme) has been isolated using a similar in vitro technique (in vitro selection) to catalyze the cleavage of a phosphodiester bond. Similar in principle, both SELEX and in vitro selection are combinatorial chemistry technique that enables the …