Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"7α-hydroxylase"”.
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Characterization of the FTF/HNF-4 Sites Within the 7Alpha- and the 12Alpha-Hydroxylase Promoters Involved in the Bile Acid-Mediated Transcription of their Regulation
… mainly two enzymes in the classic pathway, the 7α-hydroxylase and the 12α-hydroxylase. In the early 1990's it was shown that the regulatory responses of 7α-hydroxylase are mediated at the transcriptional level and since then many positive and negative transcription factors that mediate …
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Genetic Determinants of Human Serum Sterol Levels
… is produced in the brain by cholesterol 24-hydroxylase (encoded by the CYP46A1 gene). Disruption of this gene in the mouse causes severe learning defects, but it is not known whether mutations in the human gene cause the same phenotype. To overcome the uncertainty inherent in guessing what …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
… acids need to be tightly regulated. Cholesterol 7α-hydroxylase (CYP7A1), a liver specific P450 enzyme, is the first and rate-limiting enzyme in this process. Increased levels of bile acids repress transcription of CYP7A1 in a feedback manner. In response to elevated bile acid levels, the nuclear …